羟基苯

There six chapters in this dissertation: the overview on the study of probing for reactive oxygen species, spin-labelled fluorophore as probe for free radicals, Fe -EDTA chelate-induced aromatic hydroxylation of terephthalate as a new method for the evaluation of hydroxyl radical-scavenging ability, study of fluorimetric method for the determination of peroxynitrite, study of spiro-formed rhodamine B hydrazide as a novel fluorescent probe in analytical chemistry, the conclusion and prospect of the present research work.

本论文分六章，包括生物活性氧表征的研究进展、自旋标记荧光探针表征自由基的研究、利用Fe-EDTA引发对苯二甲酸芳环羟基化反应评价抗氧化剂清除羟基自由基能力的研究、荧光法表征过氧亚硝酸根的研究、螺环型罗丹明B酰肼化合物作为新型荧光探针的性质及应用的研究、结论与展望。

Hydroxy-2,3-dihydro-4-quinolone is synthesized by the basic material of 4-nitrochloro-benzene. It has investigated the routes, conditions and purifies methods in this paper, which provides bases to lucubration and industrialization. This study belongs to the field of medical intermediates.

本文以4-硝基氯苯和丙烯酸为基础原料合成6-羟基-2，3-二氢-4-喹啉酮，并对6-羟基-2，3-二氢-4-喹啉酮的合成条件和纯化方法进行了实验研究，为后续的深入研究和工业化生产提供依据。

Therelationship of the amount of catalyst and the ee% of product was seen to be negative nonlin-ear. Catalyst 3 was used in the enantioselective addition of diethylzinc to aromatic aldehydesand gave good results. The configuration of products was determined by the configuration ofthe catalysts' chiral carbon linked with hydroxy group. Using β- amino alcohols bearing only one chiral center as catalysts for the enantiose-lective addition were studied. D-N, N-dialkyl-2-amino butanol gave poor catalytic effect be-cause of their structure. The configuration of the product is the same as the catalyst. Anotherkind of β- amino alcohols - phenylglycine derivatives and valine derivatives have chiralcenter on the carbon linked with amino group. Catalyzed by-phenylglycine derivatives 6,7, 9, 10, the reactions gave satisfied results. The optical yields exceeded 80%.

在探讨了含有两个手性中心的β-氨基醇之后，选择了只有一个手性中心的β-氨基醇，一是手性中心为连羟基的手性碳原子：D-N，N-二烷基-2-氨基丁醇；二是手性中心为连氨基的手性碳原子：D-苯基甘氨酸衍生物和L-缬氨酸衍生物。D-2-氨基丁醇的催化效果不太好，这与其结构的空间位阻较小有关系，反应产物与连羟基手性碳构型一致；由苯基甘氨酸和缬氨酸出发合成五种β-氨基醇6-10，研究了不同ee％的-6作用下的二乙基锌-苯甲醛加成反应，发现该催化剂具有不对称放大效应；-7，9，lO的催化效果也比较令人满意，光学产率80％以上，所得产物构型与催化剂构型一致。

The result indicates thato-PD is converted to one trimer with ca.

羟基自由基抑制剂和氧合血红素物种抑制剂尿酸都不抑制该氧化反应，这些结果表明邻苯二胺的羟基化反应没有包括在其氧化过程中。

METHODS: Based on the antitumor activity and structural feature of 8-chloroadenosine and retinoic acid, modifications were made at positions 5′ and 8,substituted cinnamoyl and benzoyl groups were bound at 8 position through amido and ester bonds, sulfonation and nitrosation at 5′-OH and its direct chlorination were conducted.

对腺苷的8位和8-Cl-腺苷的糖环羟基进行了结构改造，以酰胺键和酯键在腺苷的8位连接了具共轭基团的肉桂酰基和苯甲酰基，得到腺苷的维甲类似物；对8-Cl-腺苷的5′-羟基进行了甲磺酰化，硝基化以及氯代反应，得到了它的衍生物。

Sixteen compounds were separated from 80% ethanol extract of Plant A, they were:-lariciresinol,-isolariciresinol,-isolariciresinol 9-O-β-D-glucopyranoside, tanegoside B, apiginin, apigenin 7-O-β-D-glucoside, apigenin 7-O-β-neospheroside, quercetin 3-O-β-D-glucopyranoside, 1, 7-dihydroxy-3, 4-dimethoxyxanthone, 3-O- [α-L-rhamnopyranosyl (1-4 ] -β-D-glucopyranoside-(25S)-5β-spirostan-3β-ol , 3β-O-D-glucopyranoside quinovic acid, mangiferin , 3'-p-hydroxybenzoyl-mangiferin, physcion, benzenyl methanol β-D-glucopyranoside and Vanillic acid.

结果： 1。从植物A的80％乙醇提取物中共分离得到16个化合物，分别为：-落叶松脂醇、-异落叶松脂醇、异落叶松脂醇9-O-β-D-吡喃葡萄糖苷、tanegoside B、芹菜素、芹菜素7-O-β-葡萄糖苷、芹菜素7-O-β-新橙皮糖苷、槲皮素3-O-β-D-吡喃葡萄糖苷、1，7-二羟基-3，4-二甲氧基-口山酮、菝葜皂苷元-3-O-[α-L-吡喃鼠李糖基（1-4）]-β-D-吡喃葡萄糖苷、喹诺酸3β-O-D-葡萄糖苷、知母宁、3′-对羟基苯甲酸-知母宁、大黄素甲醚、苯甲醇-β-D-吡喃葡萄糖苷、香草酸。

The results showed polymeric diaryliodonium salts were effective aryl ion transfer reagents. Thirdly, a new type polymer supported hypervalent iodine reagents poly { [4-Hydroxy iodo] styrene} has been developed. It was an effective oxidative reagent, and could be applied to the one pot synthesis of 4-arylthiazoles.

然后，我们以聚苯乙烯羟基对甲苯磺酰氧基碘苯为原料，成功制备了一类新型聚合物高碘试剂—聚苯乙烯负载的炔基碘盐，并研究了其作为炔基转移试剂的有效性：(1)该试剂可对硫、氮、硒等负离子进行亲电炔基化反应，合成炔基亚砜、0，0-二烃基二硫代磷酸炔基酯、1-苯乙炔基苯并噻唑以及炔基硒醚。

A series of novel polys: poly, poly and their copolymer poly were synthesized at high temperature by nucleophilic polycondensation of bisphenol 4 (3 phenyl 4 hydroxyphenyl) 2,3 phthalazin 1 one with activated difluorodiphenylketone, dichlorodiphenylsulfone and both together.

将苯基取代类双酚化合物 4-(3 -苯基-4-羟基苯基)-2 ，3 -二氮杂萘-1 -酮与活性双卤单体如 4，4 -二氟二苯酮、4，4 -二氯二苯砜进行高温缩聚反应，合成了高分子量的新型苯基取代杂萘联苯型聚芳醚材料；用1 H NMR、FT-IR表征了类双酚单体及聚合物的结构。

A series of polys based on pyromellitic dianhydride, biphenylyl tetracarboxylic dianhydride, thiodiphthalic dianhydride bis benzene dianhydride and oxydiphthalic dianhydride were prepared in different solvents.

以所合成的AB_2单体为原料，合成了一系粘度较低、溶解性良好，带端酚羟基、苯甲酰基、乙酰基、氰代苯基和苯酰苯亚胺基的芳香族超支化聚酰亚胺，通过核磁波谱、红外光谱分析和元素分析对其结构进行确证。

The experiment consist of two parts :the first one research nucleophilic addition of m-dinitrobenzene, nucleophilic reagent is benzyl cyanide; the second one synthesize 2,4-dihydorxybenzophenone from 2,4-dichlorobenzophenone and NaOH.

实验分为两部分：第一部分研究了间二硝基苯的亲核加成反应，亲核试剂为苄基腈；第二部分是用2，4-二氯二苯甲酮与氢氧化钠反应制备2，4-二羟基二苯甲酮。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。