羟基脯氨酸

Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.

我们以水杨酰胺为起始原料，经Reformatsky反应、烷基化、Diekmann环合、烯醇化、酯化等反应合成双环母核2；再从L-羟基脯氨酸出发，经酯化保护羧基、保护氨基、保护羟基、硼氢化还原酯得醇、Sn2取代和Mitsumobu反应等合成巯基侧链3；最后由化合物3经脱保护、水解得硫醇，和化合物2在二异丙基乙基胺的作用下缩合，最后Pd／C催化脱保护，历经16步反应最终得到产物多尼培南。

A method of capillary electrophoresis with tris (2,2′-bipyridyl) ruthenium electrochemiluminescence detection has been applied to the simultaneous determination of proline and hydroxyproline in human urine.

1引言胶原蛋白中常含有丰富的脯氨酸和羟脯氨酸，其中Hyp几乎为胶原蛋白所特有。在胶原蛋白代谢中，Pro通过羟基化形成Hyp，胶原蛋白降解释放的Hyp从尿中排泄[1]。

Hydroxyprolisilane CN, mineral spring essence,β-glucosan, hyaluronic acid, collagen.

羟基脯氨酯硅烷醇 CN ；矿泉精华；β一葡聚糖；透明质酸；胶原蛋白

They were two new compounds, [cyclo(Pro-Val-Phe-Phe-Pro-Val-Phe-Ser-Leu),7],[2-N-(1-methoxycarbonylethyl)guanosine, 10], and eight known compounds,(p-hydroxybenzoic acid, 1),(methyl succinate, 2),(russulaceramide, 3),(phenylalanine, 4),(guanine, 5),(β-carboline, 6),(uridine, 8), and (adenosine, 9). All the compounds were isolated from Amanita exitialis for the first time.

分别为：对羟基苯甲酸(p-hydroxybenzoic acid，1)、丁二酸二甲酯(methyl succinate，2)、神经酰胺(russulaceramide，3)、苯丙氨酸（phenylalanine，4）、鸟嘌呤核苷(guanine，5)、β-咔啉(β-carboline，6)、环（脯氨酸-缬氨酸-苯丙氨酸-苯丙氨酸-脯氨酸-缬氨酸-苯丙氨酸-丝氨酸-亮氨酸） [cyclo(Pro-Val-Phe-Phe-Pro-Val-Phe-Ser-Leu)，7]、尿嘧啶核苷(uridine，8)、腺嘌呤核苷(adenosine，9)、2-N-(1-甲氧羰基乙基)鸟苷[2-N-(1-Methoxycarbonylethyl)guanosine， 10]。10个化合物均为首次从致命鹅膏中分离得到，其中化合物7和10为新化合物。

Hydroxy praline – The main sources of hydroxyl praline are carrots, lettuce, beetroots, turnips, cucumber, plums, cherries, figs, radishes, grapes, olives, pineapples, almonds and coconut.

羟基脯氨酸-的主要来源羟脯氨酸是胡萝卜，生菜， beetroots ，萝卜，黄瓜，李子，樱桃，无花果，萝卜，葡萄，橄榄，菠萝，杏仁和椰子。

Firstly, synthetic racemates of β- amino acids were resolved into their enantiomers by ehiral ligand - exchange flash chromatography with L - hydroxyproline chemically bonded to irregular silica as the stationary phase and aqueous solution containing cupric ions as the mo

首先合成L-羟脯氨酸硅胶键合手性固定相，用于快速色谱中3-羟基-4-甲氧基-β-苯丙氨酸对映体的制备分离，考察了流动相中Cu^2＋浓度、样品体积等因素对分离的影响。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。