羟基化反应

The results indicate that improving temperature to reflux, using low polarity solvent as dispersion medium and proper molar ratio of tetrabutyl titanate to stearic acid can bring out good modification. The function of tetrabutyl titanate is to react with the surface hydroxyl groups and adsorbed H2O on the powder particles to produce new binding sites such as M—O—Ti—OC4H9and M—O—Ti—OH, which can easily react with the carboxylic acid. As temperature increases from room temperature to reflux temperature, the reactions between RCOO- and Ti change from coordinate bonds to covalent bonds, which makes the carbon chains of stearic acids more strongly bound with the powder particles surface.

研究结果表明，提高处理温度、适当增加复合改性剂中硬脂酸的量并选用极性弱的有机溶剂可达到比较理想的改性效果；钛酸四丁酯的作用是与粉体粒子表面的羟基以及吸附水反应产生偶联点，如M—O—Ti—OH，这些偶联点易于与羧酸反应；在低温时RCOO-与偶联点的Ti之间以配合物的形式发生作用，在回流温度下处理时，主要发生酯化反应，使硬脂酸更牢固地嫁接到粉体粒子表面，改性效果更好。

1H NMR spectroscopic analysis of aromatic protons combined with theoretical analysis of molecular structures proved the existence of two rotational isomers at 300 K, as well as a rapid interconversion equilibrium at 330 K for both compounds Ⅰ and Ⅱ. However, only one conformer exists for compound Ⅲ and puerarin containing 7-phenolic hydroxyl instead of propyl in A-ring as the case of compounds Ⅰ and Ⅱ. Based on UV-Visible absorption data of neutral and basic solutions, and on the density function calculations, the 7-phenolic hydroxyl group in A-ring was found to be more acidic than the 4'-phenolic hydroxyl group in B-ring. The mechanism of derivation reaction and the structure-reactivity relationship of puerarin as an antioxidant were further discussed.

其中7-丙基葛根素Ⅱ属于新型取代衍生物；变温1H NMR和理论计算结果表明，在300 K时，葛根素和4'-丙基葛根素以单一构型存在；而7，4'-二丙基葛根素和7-丙基葛根素则存在两种核磁可分辨的旋转异构体，当温度升至330 K时，两种异构体可以相互转化；通过对比分析葛根素及其衍生物脱质子产物的紫外可见吸收光谱并结合理论计算，确定了A环上7位酚羟基比B环上4'位酚羟基先脱去质子，并由此进一步阐明了葛根素衍生化反应机理以及在抗氧化作用中可能的活性位点和结构活性关系。

This specific preparation methods including: parathion of the initial reaction in acid and zinc metal in the common under redox reaction, a product of the reduction of parathion - parathion, with the sodium nitrite in the cold under diazotization reaction, and bovine serum protein tyrosine on the o-hydroxy combination of the adult immune original and immune rabbit polyclonal antibody preparation.

本发明制备方法具体包括：以对硫磷为反应初始物，在酸和金属锌的共同参与下进行氧化还原反应，得对硫磷还原产物对氨基对硫磷，再与亚硝酸钠在低温下进行重氮化反应后，与牛血清蛋白酪氨酸上羟基的邻位结合，制备成人工免疫原，并免疫新西兰大白兔制备多克隆抗体。

In the scheme,the key reactions were Grignard reaction, dihydroxylation,S_N2 substitution of hydroxyl and epoxide under acidic conditions and etc.

合成过程中的关键反应为Grignard反应，双羟化反应，质子酸催化的羟基与环氧的S_N2亲核取代成环反应。

By the mechanism of the electrocyclic reaction, three groups of 4-hydroxy-2-cyclobutenones 4 were designed and synthesized to investigate their behaviors underthe thermolysis conditions Meanwhile, a new procedure for preparation of 2(5H)-furanone 5 Was discovered.

根据电环化反应机理，我们设计了三组不同类型的4-羟基-2-环丁烯酮(4)。通过对4-羟基-2-环丁烯酮(4)进行热解，发现了一种制备2(5H)-呋喃酮类化合物(5)的新方法。

As to the curing reaction of the modified phenolic epoxy resins, there is the etherification reaction between phenolic hydroxyl groups and epoxy groups. When the secondly modified epoxy resins are cured at higher temperatures respectively, the absorbance increasing at 1670Cm〓 and 1640Cm〓 are indicative of aminolysis reaction.

对于改性酚醛环氧树脂的固化反应，有酚羟基和环氧基间的醚化反应，二次改性环氧树脂在较高的温度固化时，1670Cm〓和1640Cm〓吸收峰的增加说明有氨解反应。

In this dissertation, I will represent my studies on the nitration of Chalcone derivatives, reaction of epoxide ketone, and the aromatization of 3,5-disubstitued 2-isoxazolines with nitric oxide.

本文主要研究了：(1)NO与查尔酮及其衍生物的硝化反应，反应以较高的产率得到了a-硝基化合物；(2)NO对环氧酮的开环反应，反应生成了顺式羟基硝酸酯；(3)3，5-二取代的-2-异恶唑啉在NO作用下可以发生芳环化反应，生成了对应的2-异恶唑化合物。

In a similar way, using N,N\'-dibenzyl tartamide as auxiliary,-(2-methyl)allyl-2-chloro-phenyl-methyl azide, a vital intermediate of Repaglinide, can be prepared via asymmetric allylation of o-chlorobenzaldehyde in

产物经氧化和碘加成内酯化反应得到阿伐他汀中间体(3R，5S)-3-羟基-5-碘甲基戊内酯(10)；将N-苄基酒石酸二酰胺用于邻氯苯甲醛的不对称烯丙基化反应以较高光学收率得-甲基烯丙基-2-氯苯基-甲基醇

The method comprises following steps: reacting hydroxylation carbon nano-tube successively with reagent containing halogen and hydrosulphide to prepare sulfhydryl carbon nano-tube; reflowing the sulfhydryl carbon nano-tube and platinum salts in polyatomic alcohol, processing in hydrogen atmpsphere to obtain sulfhydryl anchoring platinum / carbon nano-tube catalyst; reflowing the sulfhydryl carbon nano-tube successively with the hydrochloroauric acid and the platinum salts in polyatomic alcohol, processing in hydrogen atmpsphere to obtain sulfhydryl anchoring platinum-gold / carbon nano-tube catalyst.

本发明将市售羟基化碳纳米管先后与含卤试剂和氢硫化物反应得到巯基化碳纳米管。再将巯基化碳纳米管与铂盐在多元醇中回流，氢气氛中处理得到巯基锚固铂/碳纳米管催化剂。将巯基化碳纳米管依次与氯金酸和铂盐在多元醇中回流，氢气氛中处理得到巯基锚固铂-金/碳纳米管催化剂。

Then we completed the first total synthesis of-Plakoridine A using Eschenmoser couping reaction as akey step. During the synthesis we found the choice of protecting groups and the configuration of the chiralcenter of the substrate play an important role to the key Eschenmoser reaction,so we think our successwould be of guide for synthesizing other polysubstituted pyrrolidines or piperidines.

在论文的第一章中，我们先以易得的对羟基苯乙酸乙酯为原料经多步反应制得了所需的β氨基酸酯，然后利用立体选择性的Aldol缩合反应和内酰胺化反应制得了Plakoridine Alactam，随后，以Eshenmoser缩合反应为关键步骤完成了生物碱-Plakoridine A的首次不对称全合成。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。