羟基化反应

The basic structural motive of alkali lignin is similar with phenol, containing phenol-carbonyl, alcohol-carbonyl, metonym and other active groups, and it can set off a reaction of carbonyl modification.

碱木素基本结构单元分子类似于苯酚，含有酚羟基，醇羟基，甲氧基等活性基团，可以发生羟甲基化等改性反应。

The 1,5-Bis(4-aminophenylazo) anthraquinone, 1,5-bis(4-hydroxyphenyl azo) anthraquinone and 1,5-bis(3-methyl-4-hydroxyphe nylazo) anthraquinone were synthesized by diazotizing 1,5-biaminoanthraquinone with nitrosyl sulfuric acid and coupling with aniline, phenol and o-cresol.

合成以1，5-二氨基蒽醌为原料，经亚硝酰硫酸重氮化，分别和苯胺、苯酚及邻甲酚偶合，得到双（4-氨基苯）－1，5-二偶氮蒽醌，双（4-羟基苯）－1，5-二偶氮蒽醌和双（3-甲基－4-羟基苯）－1，5-二偶氮蒽醌，反应产率达47%~62%。

Benzyloxy benzoyldimethylsulfoxide was prepared by the reaction of ethyl 4-benzyloxybenzoate and dimethyl sulfoxide in the presence of sodium hydride, followed by Pummerer reaction with concentrated hydrochloric acid to afford eo-hydroxy-co-thio-methyl-(4/-benzyloxy) acetophenone, which reacted with urea, thiosemicarbazide, semicarbazide hydrochloride and o-phenylenediamine to give imidazolidine-2,4-dione, l,2,4-triazine-3- one and quinoxaline derivatives, respectively.

本文用4-苄氧基苯甲酸乙酯和二甲亚砜为原料，在氢化钠存在下反应，合成了(4′-苄氧基)-苯甲酰基-二甲亚砜。研究了该亚砜在浓盐酸的存在下发生的Pummerer重排反应，用重排产物ω-羟基-ω-甲硫基-(4′-苄氧基)-苯乙酮分别与尿素、氨基脲、氨基硫脲和邻苯二胺反应合成了2，4-咪唑啉-二酮、1，2，4-三嗪-3-酮、喹喔啉等含氮杂环化合物。

It is closely related between HA implant fibrovascularization and inflammatory reaction; VEGF may be involved in the formation of fibrovascularization, dexamethasone may be through inhibiting the inflammatory response and VEGF expression, and thus inhibit implants of fibrovascular growth.

羟基磷灰石植入物纤维血管化与炎症反应密切相关，VEGF可能参与了纤维血管化形成过程，地塞米松可能通过抑制植入物的炎症反应及 VEGF的表达。

Propargyl alcohol was protected by dihydrophran with the catalysis of PPTS ,and then reacted with Ethyl Mag bromide to prepare its corresponding Grignard reagent.

炔丙醇在 PPTS 催化下由二氢吡喃保护，与溴乙烷格氏试剂反应生成相应的格氏试剂，然后与氯甲酸甲酯反应得到羟基丁炔酸甲酯四氢吡喃醚，在 PPTS 催化下脱保护后进行甲磺酰化，由溴化钠进行溴取代后合成了4-溴-2-丁炔酸甲酯，总收率达53%。

The hydrophobic core serves as a reservoir for water-insoluble drugs.Hence,these nanoparticles can be used as carriers for hydrophobic drugs.For the synthesis of cholesterol-modified glycol chitosan conjugates,a carboxyl group was initially introduced to cholesterol molecule using succinic anhydride,and then covalently coupled with the primary amino group of glycol chitosan in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride and N-hydroxyl succinimide.

本文采用二步反应将胆固醇接枝到乙二醇壳聚糖，首先将胆固醇进行羧基化，将胆固醇与琥珀酸酐反应生成胆固醇半琥珀酸酯，然后用1-乙基-3-(3-二甲基氨丙基)碳二亚胺盐酸盐与N-羟基琥珀酰亚胺作为偶联剂，将胆固醇半琥珀酸酯的羧基与乙二醇壳聚糖主链的氨基进行反应，得到胆固醇疏水改性乙二醇壳聚糖共聚物。

In the same reactor, telon fast green 5G was synthesized through condensation and sulfonation processes with 1,4,5,8-hydroxyanthraquinone and p-toluidine as main raw materials.

由1，4，5，8—四羟基蒽醌和对甲苯胺为主要原料，在一个反应器内同时完成了缩合和磺化两步单元反应，合成酸性蒽醌绿染料，并对其反应条件对产物收率的影响进行了研究，确定了最佳合成工艺条件(反应时间16 h、反应温度120℃、原料的配比1：2.2)。

The optimum technical parameters were obtained as follows:bromating temperature is 15℃,solvent is methyl arcohol, bromating agent is BrCl,the molar ratio of 4-hydroxy-benzaldehyde to BrCl is 1:1.15,reaction time is 2.5 hours.

其工艺参数优化如下：溴化时反应温度选择15℃，溶剂选择甲醇+乙酸甲酯，溴化剂选择氯化溴，对羟基苯甲醛与氯化溴之比为1∶1.15，反应时间选择2.5个小时，滴溴时间约半个小时。

Reaction of L-tyrosine with benzyl bromide in the presence of copper sulfate led to the protection of phenol group on the side chain of L-tyrosine to give H-Tyr-OH in 45% yield via a copper complex intermediate.

酪氨酸与溴化苄在硫酸铜存在下反应，选择性地在其侧链酚羟基上引入苄基保护基，通过反应条件的优化，反应产率达到45%。

Because a part of hydroxyl group in methyl cellulose were substituted by trimethylsilyl group , the product could be dissolved in amounts of common organic solvents, such as chloroform, xylene and so on.

通过甲基纤维素与六甲基二硅亚胺的反应，成功地实现了对水溶性物质甲基纤维素醚三甲基硅化的改性；红外光谱验证了反应的发生，核磁共振氢谱确定了三甲基硅甲基纤维素的取代度；纤维素醚上的部分羟基被三甲基硅化后取得了在普通溶剂中的良好的溶解性，且随着取代度的增加，在非极性溶剂中的溶解性逐渐变好；通过热失重实验，对其热稳定性进行了测试。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。