羟喹啉

Our chief products include as follows: 5-Nitro-8-hydroxy Quinoline, 8-Aminoquinaldine, 8-Hydroxyquinoline Sulfate, 5,7-Dichloro-8-hydroxyquinaldine, 5-Nitro-0-cresol, 6-Nitro-m-cresol, 2'-Chloroacetophenone, 4-Methyl-5-thiazole ethanol, 4-Aminophenethyl alsohol.

主要产品有：硝羟喹啉，8-氨基喹啉，8-羟基喹啉硫酸盐，8-羟基喹哪啶，5，7-二氯-8-羟基喹哪啶，5-硝基邻甲酚，6-硝基间甲酚，邻氯笨乙酮，4-氨基笨乙醇，4-甲基-5-噻唑乙醇，3-羟基吡啶等。

The products include two series: Sulfa drugs Industrial Sulfanilamide, Crystel Sulfanilamide, Sulfaguanidine, Sulfadimidine(Sodium, Sulfadiazine, Sulfathiazole Sodium, Sulfaquinoxaline Sodium, Sulfameter Dimethyl Sulfate, Nitromethane, Hydroxylamine Hcl.

本公司专业生产化工、医药中间体，产品主要包括磺胺（工业磺胺、结晶磺胺、磺胺脒、磺胺二甲嘧啶、磺胺嘧啶、磺胺噻唑钠、磺胺喹噁啉钠、磺胺五甲氧嘧啶）及硫酸二甲酯（硫酸二甲酯、硝基甲烷、烟酸羟胺）两大系列。

According to the result, we believed that the reason resulted in the low sensitivity was that the marker residue compound MQCA structure has changed after conjugated with protein and the antibody induced by the conjugation could not recognize the free MQCA in the ci-ELISA. Therefore we designed some hapten which could reserve the marker residue structural speciality mostly. After synthesis route selection and optimum, the hapten 7-Hydroxymethyl-3-methyl-quinoxaline-2-carboxylic acid was synthesized, used 4-methyl-2-nitroaniline as the start material via six steps, such as oxidation cyclization, bromize reaction, hydrolysis, Beirut reaction, reduction, hydrolysis. This work established basis for producing the high affinity antibody and developing the sensitive ELISA residue detection method.

本论文认为导致ELISA检测灵敏度较低的原因，是残留标示物和蛋白偶联后的特征结构发生改变，诱导产生的抗体不能够对游离MQCA很好的识别，因此，本论文设计了能够最大化保留MQCA结构特征的系列半抗原结构，并对其合成路线进行了筛选和优化，最终以对甲基邻硝基苯胺为起始原料，经氧化环化、溴代、水解、Beirut缩合、还原、水解六步反应制备含羟甲基结构的MQCA衍生物7-羟基甲基-3-甲基-喹噁啉-2-羧酸，为制备对游离残留标示物高亲和力的抗体，高灵敏度的ELISA残留检测方法的建立奠定基础。

Methods and Results-Using a micro-single-photon emission computed tomography small-animal imaging system and a Food and Drug Administration-approved radiotracer [indium 111] oxyquinoline,(111In-oxine, we demonstrate here that monocyte recruitment to atherosclerotic lesions can be visualized in a noninvasive, dynamic, and 3-dimensional fashion in live animals.

方法和结果：我们通过Micro-SPECT小动物显像系统和FDA批准的示踪剂（铟111-羟化喹啉），证实单核细胞向AS病变处募集过程可以被非侵入性影像技术动态、三维模式观察到。

IDO inhibits the proliferation of eukaryotic intracellular pathogens or tumor cells by depriving them of tryptophan. IDO has been targeted for neurological disorders: it causes decrease of serotonin level in the brain resulting depression, and it causes the accumulation of neurotoxic quinolinic acid. IDO plays a key role in the suppression of T cell response and antitumor immune, it induces immune tolerance to embryo and explant.

IDO可通过降低微环境中色氨酸的浓度而达到抑制病原微生物增殖的作用； IDO与神经系统疾病也密切相关，它能降低5-羟色胺的水平而导致抑郁，也可造成脑中喹啉酸等具有神经毒性的代谢产物的累积； IDO在抑制T细胞免疫和抗肿瘤免疫、诱导母胎免疫耐受和移植物免疫耐受中均发挥重要的代谢性免疫调节作用。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。