缺氧的

Sanchez ET ,Botella LM ,Velasco B ,et al. Synergistic cooperation between hypoxia and transforming growth factor2beta pathways on humanvascular endothelial growth factor gene expression. J Biol Chem ,2001,19,276:38527238535.[3] Blancher C,Moore JW,Talks kl,et al.Relationship of hyposia-inducible factor HIF-1alpha expression to vascular endothelial growth factor I nduction and hypoxia survival in human breast cancer cell lines.

肝细胞癌中缺氧诱导因子-1α、热休克蛋白70的表达】；综上所述，肝细胞癌发生后，由于血供不足诱导HIF-1α过度表达，应激状态下产生的HSP70通过减轻缺血性损伤，增加毛细血管的生成及减轻细胞凋亡等途径使肿瘤细胞的增殖、移行加快，促进恶性肿瘤的生长、浸润和转移，使肿瘤细胞在适应缺氧、能量代谢、细胞凋亡及转移中起重要作用。

Hypoxia induces the resistance of tumor cells[4];and the heterogeny of solid tumors result in the appearance of subpopulations of differentproliferative potency in the same tumor tissue, so that the target cells sensitive to cell cyclespecific drug are reduced.

目前有研究认为：实体瘤部分细胞缺氧和肿瘤组织的异质性可能是导致肿瘤对放疗和化疗产生耐受的主要原因之一，缺氧可以诱导肿瘤细胞对放疗和化疗的耐受性[4]，实体肿瘤的异质性可使同一瘤组织内具有不同增殖潜能的癌细胞亚群存在，导致细胞周期特异性化疗药物作用的靶细胞减少。

The Lower/Upper Cretaceous boundary in Songliao Basin is,therefore,between the Quantou and Denglouku formations,instead of between the Quantou and Qingshankou formations.2.The dark mudstones and shales in the Member 1 of Qingshankou Formation are of high organic carbon and low diasteranes contents.Organic geochemical characters are illustrated by biomarkers of 28,30-bisnorhopane and gammacerane,and positive excursion of kerogen isotopes.It is suggested that the dark mudstones and shales in the Member 1 of Qingshankou Formation are the products of lake anoxic period.It corresponds to the oceanic anoxic event at Cenomanian-Turonian boundary in Cretaceous.3.Based on the study of biostratigraphy,chronostratigraphy,magnetostratigraphy and event stratigraphy,a correlation of the lacustrine sequence to marine standard has been proposed,i.e.,the Quantou Formation corresponds to Cenomanian stage,Qingshankou Formation correlates to Later Cenomanian-Early Turonian,Yaojia Formation to Later Turonian-Coniacian,Nenjiang Formation to Santonian-Campanian.Sifangtai and Minshui Formations to Maastrichtian. 4.Analysis of lithology,lithofacies and microfossils of Cretaceous in Songliao Basin, shows that shore and shallow lake facies yield the most abundant microfossil groups,and the predelta and deltaic distributary plain facies rich in fossils as well.In the shore and shallow lake areas during the high level periods(such as Qingshankou and Nenjiang sedimentary periods),the lacustrine biota are of high diversity and high abundance.

因此，松辽盆地上、下白垩统的界线应在泉头组的底界，即泉头组与登娄库组之间，而不是泉头组的顶界。2、青山口组一段黑色泥岩、页岩具有有机碳含量高、重排甾烷含量低，生物标志物出现28，30—双降藿烷和伽马蜡烷，干酷根碳同位素具有正向偏移等有机地球化学特征，表征为青山口组一段黑色页岩、油页岩是古湖泊缺氧事件的产物，它对应于白垩纪古海洋Cenomanian—Turonian期界线附近缺氧事件，二者具同步性。3、通过生物地层学、年代地层学、磁性地层学和事件地层学研究，认为泉头阶大体相当于Cenomanian阶，青山口阶相当于晚Cenomanian—早Turonian阶，姚家阶对应于晚Turonian—Coniacian阶，嫩江阶对应于Santonian—Campanian阶，四方台阶和明水阶相当于Maastrichtian阶。4、通过对松辽盆地上白垩统的岩性、岩相及微体化石分析，认为滨浅湖相是微体生物群最为发育的相带，其次为三角洲前缘相和三角洲分流平原相。

But inner hair cell and tectorial membrane were normal.4. The quantities of nNOS and iNOS increased obviously in the cochlea of HIE rats.

1。缺氧缺血时，nNOS和iNOS在新生大鼠耳蜗的内、外毛细胞，血管纹，螺旋神经节等细胞的分布增多，但两者的活性变化不同，分别在缺氧缺血的早期和晚期时活性最强。

Objective To study the MR findings and its relationship with clinical manifestions of cerebral palsy caused by hypoxic-ischemic brain damage.The pathological mechanisms of MR findings were also explored.Methods The MR findings of14patients with cerebral palsy caused by hypoxic-ischemic damage were studied retrospectively and correlated with clinical findings.All those patients underwent MRI.Cerebral cortex and subcortical white matter,deep white matter,basal regions and thalami,and ventricles and subarachnoid space were observed on T1WI and T2WI.

目的 通过分析14例缺氧缺血性脑损伤所致脑瘫的MR成像特点及临床表现，讨论了该病的MRI表现与临床表现的相关性，以及MRI表现的病理损伤机制方法对14例缺氧缺血性脑损伤所致脑瘫患儿行MR检查，在T1WI及T2WI上对脑皮层及皮层下白质、深部白质、基底节、丘脑、以及脑室和蛛网膜下腔等部位进行观察。

HIF-1α is an oxygen-regulated protein and is recognized as a positive factor to tumorigenesis. During nomoxia, HIF-1α is rapidly hydroxylated by prolyl hydroxylase then goes into 26S proteasome degradation pathway. During hypoxia, HIF-1α accumulates and dimerizes with HIF-1β to transactivate hypoxia-responsive gene expression.

中文摘要缺氧诱导性因子-1α(HIF-1α)为一种对於氧分压敏感的转录因子，在正常氧分压下HIF-1α很快就被prolyl hydroxylase氢氧化进入26S蛋白酶体降解，当细胞处理缺氧环境时HIF-1α会累积并与HIF-1β形成复合物进行转录活化的作用；HIF-1α所调控的基因包括影响能量供给、细胞生长、血管新生等，被认为在肿瘤发育过程扮演促进者的角色。

HIF-1α is an oxygen-regulated protein and is recognized as a positive factor to tumorigenesis. During nomoxia, HIF-1α is rapidly hydroxylated by prolyl hydroxylase then goes into 26S proteasome degradation pathway. During hypoxia, HIF-1α accumulates and dimerizes with HIF-1β to transactivate hypoxia-responsive gene expression.

缺氧诱导性因子-1α(HIF-1α)为一种对於氧分压敏感的转录因子，在正常氧分压下HIF-1α很快就被prolyl hydroxylase氢氧化进入26S蛋白酶体降解，当细胞处理缺氧环境时HIF-1α会累积并与HIF-1β形成复合物进行转录活化的作用；HIF-1α所调控的基因包括影响能量供给、细胞生长、血管新生等，被认为在肿瘤发育过程扮演促进者的角色。

Cell lines were co-tranfected with bi-plasmids and cultured at 1% O〓 condition, luciferase assay demonstrated that all of the expression systems with different domains could be hypoxia-activated. GAL-CAD achieved more than 100-fold induction in A549 cell and more than 40-fold in HepG2; expression level of the system markedly increased after addition of glycin arm, almost 10-fold enhancement in HepG2 cell. Because basic expression also increased, the induction fold by hypoxia decreased.

双质粒共转染不同细胞株后，在1％O〓环境下培养24h，荧光素酶活性检测结果提示含不同结构域的表达系统均有受缺氧激活的能力，其中GAL-CAD在A549中获得100倍以上的诱导，在HepG2中获得40倍以上的诱导；加入甘氨酸臂后该表达系统的转录活性大为增强，在HepG2细胞中增强了10倍以上，但是由于基础表达也有所增加，受缺氧诱导的倍数下降。

In the current study, anoxic dechlorinations of p, p'-DDT,γ-HCH, HCB in the Liao River sediment were studied under the following conditions: without any additional short chain carbon substrates or vitamin B〓; with the addition of short chain carbon sources (including sodium lactate, sodium propionate or sodium acetate); with the addition of vitamin B〓; with the addition of both short chain carbon substrates and vitamin B〓, with the addition of sodium dodecyl sulfate , a kind of surfactant; the coexistence of the three chlorinated compounds.

氯代有机物一般都是典型的持久性环境污染物，其中部分氯代有机物还是环境激素类物质，例如，滴滴涕、林丹和六氯苯等，这些氯代有机物在环境中的迁移转化一直是国际环境化学领域的热点、重点课题。氯代有机物进入环境水体后，成为沉积物吸附态有机污染物的重要成分，天然水沉积物经常处于缺氧状态。因此，研究氯代有机物在天然水体沉积物中的缺氧脱氯行为是非常必要的。

With the existence of additional carbon sources, sodium lactate, sodium propionate or sodium acetate, the faster pH rised, the faster p, p'-DDT dechlorinated, which indicate that the existence of short chain organic substrate supplies sufficient electron donors for the dechlorination process, and p, p'-DDT can obtain electrons more easily during the stage of pH rising.

并且由于p，p'-DDT的还原脱氯与细胞色素氧化酶及辅基FAD有关，外加碳源下p，p'-DDT的缺氧降解多数发生在体系pH值上升的阶段，且pH值上升较快时对应的p，p'-DDT缺氧降解较快，而在无外加碳源的体系中，由于可供p，p'-DDT还原脱氯的电子量限制了p，p'-DDT还原脱氯的速度，未发现上述现象。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐