缺氧的

Objective To investigate the influence of hypoxia on the expressions of hypoxia inducible factor 1α and vascular endothelial growth factor,the angiogenic response and its mechanism.

目的：探讨缺氧对人胶质瘤细胞株U251缺氧诱导因子-1α和血管内皮生长因子表达及血管生成反应的影响及机制。

MethodsThe model of cerebral ischemia and anoxia in mice was established by decollation and ligating common bicarotid artery the effect of BVF on the survival time of the mice,and the time of catching their breath after mice decollated,and mouse brain capillary vessel permeability were observed.

方法采用小鼠断头、结扎双侧颈总动脉等脑缺血缺氧模型，观察苦菜总黄酮对脑缺血缺氧小鼠存活时间、断头小鼠喘息时间及脑毛细血管通透的影响

Part 1: Permeability of Exogenetic BDNF through placental barrier of pregnant rats and blood-brain barrier of fetus with transient uteroplacental ischemiaObjective To investigate the potential of BDNF to penetrate the placental barrier and get into the fetus and pass through the blood-brain barrier of fetus to play neuroprotective function in the condition of transient ischemia.

第一部分：外源性脑源性神经营养因子在宫内缺氧环境中对胎盘及胚鼠血脑屏障通透性的实验研究目的：探讨外源性脑源性神经营养因子在宫内缺氧环境下能否通过胎盘屏障进入胎鼠体内，再通过胎鼠血脑屏障进入胎鼠脑组织而发挥其生物功能。

The use of fetal nonstress test combined with fetal umbilical artery doppler velocimetry would improve the diagnosis for fetal anoxia,and give a reliable information to treat fetal anoxia for clinicians.

NST与多普勒脐动脉血流速度测定联合应用可以提高胎儿宫内缺氧状态的诊断，为临床及时纠正宫内缺氧提供了可靠依据。

The effect of propofol on the evoked potential, in terms of orthodromic population spike and hypoxia injury potential, were investigated in the ischemic hippocampal slices.

观察丙泊酚对缺氧海马脑片诱发电位－顺向群峰电位和缺氧损伤电位的影响。

Underlight microscope,we can find edema and few focal necrosis of right nerve cells of neonate rats after 2 to 6 hours of hypoxic-ischemia. We can find clear necrosis in brain tissue after 72 hours of hypoxic-ischemia.

HE染色缺血缺氧后2-6h右侧脑神经细胞水肿及少量局灶性坏死，缺血缺氧后72h右侧脑组织中可见界限清楚的坏死灶。

Compared by middle-stage luteal cell, luteinized granulosa cells responded an increasion in PCNA even under hypoxic condition, which spoke for an important role of hypoxia in controlling the performance of cell proliferation. Similarity was proved between luteal cell and luteinized granulosa cells when it came to the performance of cell proliferation under a condition of hypoxia.

然而，意外地发现缺氧条件下黄体化粒性细胞之PCNA蛋白质表现量反而增加，此结果与中期黄体细胞之结果恰好相反，显示此时之细胞分裂旺盛而快速增生，与黄体发育初期之细胞生理相似，且缺氧条件可能扮演著重要的调控角色。

HIF-1αprotein expression is related to hypoxia degree mimicked by cobalt chloride and related to exposure time. HIF-1αmRNA expression had no significant difference in all groups. Cobalt chloride induced HIF-1αexpression is at protein level, no transcription level.

1、HIF-1α蛋白表达与氯化钴模拟缺氧程度和时间有关，HIF-1αmRNA表达没有明显差异，提示氯化钴模拟缺氧诱导的HIF-1α调节可能发生在蛋白水平，而非转录水平。

Under hypoxic conditions, cytoplasmic HIF-1 degradation is inhibited, thereby allowing it to accumulate,dimerize, and translocate into the nucleus to promote transcriptionof a number of hypoxic molecules.

这表明急性贫血会危及脑氧平衡，在缺氧条件下， HIF-1 降解受到抑制，因此而积累， dimerize ，并转移进入细胞核，促进转录的一些缺氧分子。

It was found that in lung tissue MDA Ievel was increased signiflcantly and SOD,CATcontents were decreased markedly in hypoxic rats as compared with the control group.vitamine E showed some inhibitory effed on changes of SOD and MDA.

结果表明：与对照组比较缺氧大鼠肺组织MDA明显升高、SOD、CAT明显降低，VitE可逆转MDA和SOD的变化；缺氧大鼠血浆TXB＿2高于对照组，其浓度与肺组织MDA含量呈正相关（r＝0.65.P＜0.05）。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。