缺氧的

Using distilled water as a blank control and propranolol hydrochloride as a positive control, the survival time of mice in hypoxia under ordinary pressures, and with acute cerebral ischemia and sodium nitrite were used to evaluate the anti-hypoxic effect of three different doses (10, 15, 20 g/kg) of 65%, 95% alcohol extract and water extract of Bassia rapa L. Erythrocyte number and hemoglobin count were used to investigate the anti-hypoxic effect of 65%, 95% alcohol extract and water extract (10 g/kg) of Bassia rapa L.

通过建立小鼠常压缺氧模型、急性脑缺血性缺氧模型以及亚硝酸钠中毒模型，以蒸馏水作为空白对照，盐酸普蔡洛尔作为阳性对照，观察芫根水、65%乙醇及95%乙醇提取物的10g/kg、15g/kg和20g/kg剂量组对小鼠缺氧的保护作用，同时观察各提取物10g/kg剂量组对红细胞数量和血红蛋白含量的影响。

And it is involved in the energy metabolism, cell proliferation, hemogenesis and vessel formation and remodeling.

HIF-1α通过调节多种基因的表达来调节细胞对低氧的适应性反应，是迄今为止发现的唯一的一个在缺氧状态下发挥特异性活性的调节分子，被认为是调节缺氧相关基因表达的关键分子，它同激活蛋白(activated protein 1， AP-1)，核转录因子(nuclear factorκB， NF-κB)和p53等协同作用调节机体对缺氧的反应，其功能涉及能量代谢、细胞增殖、造血作用、血管形成、重塑与收缩等诸多方面。

Each unitis of different biotic characters and displays different features of seawater composition during the time. 2 The black unit including a biotic extinction was caused by oceanic anoxic event. Crisis that deepwater keeled foraminifera encountered represents a ferocious anoxia in deep marine environment . Biotic recovery in gray unit reflects gradually improved marine circumstance. What the biotic extinction at the C/T boundary in black unit reflects an environmental mutation, whereas the gradual biotic change characterize the recovery of marine dissolved oxygen environment in a stepwise process. The red unit is the result of oxic deposition and characterized by extremely abundance of foraminiferal faunas, which reflects a high-oxidized marine circumstance. 3 As the most ordinary biotic index in paleoceanography researches, foraminifera represent anexcellent environmental indicator in this paper.

三套岩层表现出不同的生物特征，并指示出当时海水的不同性质。2黑层段是大洋缺氧造成的结果，生物大量灭绝，深层水具旋脊有孔虫的所遭受的危机反映出当时海洋深层水体严重缺氧的特征；灰层段中生物的恢复反映出海洋环境自缺氧事件之后的逐步改善过程，与黑层段反映的C/T 界线处生物绝灭反映的环境突变不同，灰层段生物特征的渐变指示出当时海洋溶解氧环境的恢复也是一个逐步的过程；红层段属于富氧沉积的产物，特征是有孔虫生物的极度繁盛，反映的是一种高氧化性的海洋环境。3有孔虫作为古海洋研究中最常用的生物指标，在本文研究中显示了良好的环境指示性。

Objective: Hypoxia-inducible factor-1 is a transcriptive factor that regulates genes involved in metabolism angiogenesis and infiltration.

目的：缺氧诱导因子-1(Hypoxia inducible factor-1，HIF-1)是凋亡肿瘤细胞在适应缺氧的核转录因子。

Objective To investigate the expression of HIF-1α mRNA and HIF-2α mRNA in placentas of pregnant women with intrahepatic cholestasis of pregnancy.

目的 观察缺氧诱导因子-1α(HIF-1a) mRNA、缺氧诱导因子-2α(HIF-2α) mRNA在妊娠期肝内胆汁淤积症患者胎盘组织上的表达，探讨其与ICP胎儿缺氧的关系。

In response to extracellular stimuli, ERK1/2 translocates to nucleus, phosphorylates transcription factors,such as Elk1,ATF2,Sap-1α,c-myc,STAT, and so on, co-regulators and chromatin proteins to initiate transcriptional changes.

斑点杂交研究发现Ngb mRNA在大脑皮层、海马和丘脑等部位表达，缺血缺氧可使Ngb mRNA表达上调，其表达上调程度与相应区域对缺血缺氧的耐受性呈正相关。

Methods The neural model of nerve growth factor differentiated PC12 cells and hypoxic model induced by cobalt chloride were made.

建立神经生长因子诱导PC12细胞分化和氯化钴诱导化学缺氧的神经元缺氧模型。

Objective To investigate whether hypoxia preconditioning exist in adipose tissue,and construct the hypoxemic model of adipose tissue.

目的 探讨脂肪组织中是否存在缺氧预适应现象，构建CoCl2致缺氧的缺氧模型。

objective to investigate whether hypoxia preconditioning exist in adipose tissue,and construct the hypoxemic model of adipose tissue.methods after injected different density cocl2 to rat's subcutaneously of groin,use immunohistochemical method detect hif-1α protein,and use rt-pcr detect hif-1α mrna.results after injected different density cocl2,the adipose tissue of rat's groin express different degree of hif-1αprotein and hif-1αmrna.,and reach the peak when the density is 20-40 mg/kg and the time is 3 h.conclusion hypoxia preconditioning exist in adipose tissue,and the effect of preconditioning is most evidence when the density is 20-40 mg/kg and the time is 3 h.

目的 探讨脂肪组织中是否存在缺氧预适应现象，构建cocl2致缺氧的缺氧模型。方法不同浓度的cocl2大鼠腹股沟区皮下层浸润注射，分别用免疫组织化学法和rt-pcr法检测该区脂肪hif-1α蛋白和hif-1α mrna的表达情况。结果用不同浓度的cocl2行化学缺氧后在不同时间点观察有不同程度的hif-1α蛋白和hif-1α mrna表达，其中，在浓度为20～40 mg/kg，时间为3 h时脂肪组织中hif-1α表达达高峰。结论脂肪组织存在缺氧预适应现象；cocl2的浓度选择20～40 mg/kg，时间选择3 h时缺氧预适应效果较佳。

Hypoxia was imposed to the cardiomyocytes with or without daidzin pretreatment. ALDH2 activity was measured by the method of acetaldehyde metabolism. Apoptosis was measured by Hoechest 33324 staining, fluorescence activated cell soiling and the DeadEnd fluorometric TUNEL system.

运用缺氧模型，比较大鼠心肌细胞在单独缺氧和经ALDH2特异性抑制剂daidzin预处理24h后缺氧的凋亡改变，酶活性检测采用乙醛代谢法、凋亡的测定通过用Hoechest 33324、免疫荧光标记用流式细胞仪测定和TUNEL试剂盒检测。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。