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缬氨酸

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By the present of DMF, attractions arising from hydroxyl groups increased, and it is more favored to forming hydrogen bonds between amino acids; repusings arising from apolar alkyl groups side-chaines have little change ,but they increase with increasing alkyl groups, llydroxyl groups assist in the formation of hydrogen bonds in interior protein molecules, alkyl groups assist in the highly extension of peptide chaines, these make protein structure stabilized.

而L-缬氨酸非极性侧基的排斥作用在15%乙醇中最大,随乙醇含量的进一步增加,排斥作用的影响逐渐减小,吸引作用的影响逐渐占据主导,且越来越大。

With increasing DMFcontent in mixed solvents, the dipolar attracting interactions betweenglycine molecules increase; the attracting interactions arising fromhydroxyl groups between L-serine molecules increase rapidly; the repulsing interactions involving apolar side-chains between L-valine moleculeshave little fluctuate. By the present of ethanol, attractions arising fromhydroxyl groups increase obviously, repulsions arising from apolarside-chains decrease.

随溶液中DMF含量的增大,甘氨酸和L-丝氨酸两分子间的偶极吸引作用逐渐增大。L-丝氨酸羟基的吸引作用影响更加明显,因此增加速度较快。L-缬氨酸非极性侧基的排斥作用变化略有波动。

Leucine is in the highest proportion in the amino acid component, while cysteine in the lowest.

在E蛋白的氨基酸构成中,亮氨酸和缬氨酸占的比例最高;而谷氨酰胺、组氨酸和色氨酸在E蛋白中含量为零。

Results A novel polymorphism in the ABCA gene was found in two patients:M V which exists in exon7 of ABCA gene and it's cDNA location is A09G and converses amino acid from Me thionine to Valeric.

果M V是一个新发现的ABCA基因SNP,此位点在外显子7,cDNA位置为A09G,并导致位氨基酸由甲硫氨酸转变为缬氨酸

The COMT gene has two common variants with a single amino acid difference at position 158; valine or methionine.

该转移酶基因有两种较常见的变异与一个单一的氨基酸差异,在立场158条;缬氨酸或蛋氨酸。

In addition, the factory has also passed the ISO certification, ribavirin also adopted the FDA inspection, the product of the production technology of water ahead of the average domestic counterparts, the product of the production capacity are as follows: inosine for 2300 tons of raw materials / year proline API of 350 tons / year of raw materials ribavirin of 500 tons / year, ribofuranose tetraacetate 200 tons / year, valine more than 150 tons / year, product sales leader in the status of the domestic market.

不但如此,本厂还通过了ISO系统认证、利巴韦林还通过了FDA检查,各产品的生产技术水平均领先于国内同行,产品的生产能力分别为:肌苷原料为2300吨/年,脯氨酸原料药为350吨/年,利巴韦林原料为500吨/年、四乙酰核糖200吨/年、缬氨酸150吨以上/年,产品的销售市场占据国内领头羊地位。

The linear concentration ranges for γ-aminobutyric acid, valine and leucine were 5.0×10^(-3)-0.12 g/L, 5.0×10^(-3)-0.08 g/L and 5.0×10^(-3)-0.12 g/L, respectively, and the detection limits (S/N=3) were 2.5×10^(-3), 2.5×10^(-3) and 2.6×10^(-3) g/L, respectively. The relative standard deviations of the peak currents of γ-aminobutyric acid, valine and leucine were 2.5%, 4.9% and 3.9%(n=7), respectively.

氨基丁酸、缬氨酸和亮氨酸的线性范围分别为5.0×10^(-3)~0.12、5.0×10^(-3)~0.08和5.0×10^(-3)~0.12 g/L,检出限(S/N=3)分别为2.5×10^(-3)、2.5×10^(-3)、2.6×10^(-3)g/L;7次平行进样峰高的相对标准偏差分别为2.5%、4.9%、3.9%。

Among 21 kinds of aminophenol, 7 kinds are necessary aminophenol. They are Lysine, valine, leuine, lieine,serine,phenylalanine and tryptophan.

在21种天然氨基酸中有7种是必需氨基酸,分别是赖氨酸、缬氨酸、亮氨酸、异亮氨酸、丝氨酸、苯丙氨酸、色氨酸。

METHODS:This compound was synthesized via acylation and hydrogenization using aciclovir and CBZ-L-valine as meterial.

以阿昔洛韦和N-苄氧羰基-L-缬氨酸为原料,经酰化、催化氢解反应得到了新型抗疱疹病毒药物缬昔洛韦。

Results Mobiligy shifts of SSCP in exon 5 of presenilin-1 was detected in 4 cases with Alzheimer,s disease. Two missense mutation were found in the patients by DNA sequence analyse, one mutation was Leu 130 Met and the other was Vall 57 Leu.Another 11 patients showed one single strend shifted rapidly. But none mobility shifts of SSCP were found in patients with vascular dementia and normal controls. Conclusions It is shown that mutations in exon 5 of presenilin-1 also exist in the patients with sporadic Alzhemer?

结果 发现4名SAD患者的PCR产物SSCP分析发生泳动异常,DNA序列分析发现:这4名SAD患者的130号密码子发生了CTG→ATG错义突变(388位点发生C→A突变),使编码的氨基酸由亮氨酸变为蛋氨酸(Leu 130 Met);157号密码子发生了GTG→CTG错义突变(469位点发生G→C突变),使编码的氨基酸由缬氨酸变为亮氨酸(Val 157 Leu),另有11名患者SSCP表现为一条单链增快,其性质待定。

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