缩酮

According to the synthetic methods study of the quinolones, it is found that the synthetic method of parent ring is of wide use by the condensation from α-substituted aryl formyl-β-substituted aminoacrylic acid and the inner molecular nucleophilic substitution reaction, which is almost suitable for the quinolones preparation of different rings or different substituted groups in 〓-position.

然后，对其合成方法进行了归纳，发现：由α-取代芳甲酰基-β-取代氨基丙烯酸缩合，经分子内亲核取代反应形成喹诺酮母环的合成方法用途非常广，几乎适用于所有不同环系或〓-位是不同取代基的喹诺酮类衍生物的制备。

From the view of structure,α-alkenoyl ketene dithioacetals contain divinyl ketones.

从结构上看，α-烯酰基二硫缩烯酮可以看作二烯酮类物质。

The company is committed to the wholesale, retail chemical products, including: industrial toluene, xylene, white oil methanol, ethyl, n-butyl, C ketone, butanone, anti-Whitewater, cyclohexanone, etc. methylal more than 40 kinds of products, the average monthly sales volume over 4000 tons.

本公司主要致力于批发，零售化工产品，包括：工业用甲苯，二甲苯，白电油甲醇，乙酯，丁酯，丙酮，丁酮，防白水，环已酮，甲缩醛等40多种产品，平均月销量达4000多吨。

Solvent dosage is 10mL/ gram epichlorohydrin. The yield of 5-chloromethyl-2-oxazolidinone was more than 65.2%. 5-Chloromethyl-2-oxazolidinone and sodium phenolate were condensated to give 5-phenoxymethyl-2-oxazolidinone after taking off the sodium chloride in yield of 63.0%~78.0%. Dimethylsulfoxide was used as the solvent, and orthogonal experiment to the reaction condition had been carried out.

用5-氯甲基-2-噁唑烷酮和酚钠缩合，脱去氯化钠后生成5-芳氧甲基-2-噁唑烷酮类化合物，选用二甲亚砜为溶剂，对反应条件进行了正交实验，最佳条件为：反应温度120℃、反应时间20h、物料配比1：1，产率为63.0%～78.0%。

The optimum conditions were reaction temperature 120°C, reaction time 20h, mole ratio of 5-chloromethyl-2-oxazolidinone and sodium phenolate 1:1. 3,5-Dimethylphenol and epichlorohydrin in sodium hydroxide were condensated to give l,2-epoxy-3-phenoxy propane, then the reation of l,2-epoxy-3-phenoxypropane and the carbamate afforded oxazolidinone in the yields of 69.0%~76.0%. The side reaction had been avoided effectively by the uses of the excessive epichlorohydrin and mixed catalysts.

用3，5-二甲基苯酚和环氧氯丙烷在氢氧化钠存在下缩合生成苯氧基环氧丙烷，然后和氨基甲酸酯反应生成噁唑烷酮，采用过量环氧氯丙烷和使用混合催化剂，有效的避免了副反应的发生，提高了噁唑烷酮的产率，产率69.0%～76.0%。

By the reactions ofα-acylamino ketene--acetals and oxalyl chloride, a serie of pyrrolidinetriones were prepared.

通过α-酰胺基二硫缩烯酮和草酰氯的反应，成功制备了一系列吡咯烷酮类化合物。

The condensation of 3 carbethoxy isoquinol 4 one with carbamidine, amidine, carbamide and sulfocarbamide gave isoquinolo pyrimidine derivatives, respectively and isoquinolo quinoline derivatives were synthesized by the reaction of o aminobenzaldehyde or o aminopiperonal with isoquinol 4 one.

报道了利用 3 乙氧甲酰基异喹啉 4 酮分别与胍、脒、脲及硫脲类化合物缩合反应合成异喹啉并嘧啶衍生物，邻氨基苯甲醛、邻氨基胡椒醛分别与异喹啉 4 酮反应合成异喹啉并喹啉化合物。6个新化合物的结构通过元素分析、红外光谱、核磁共振氢谱和质谱予以证

In the presence of ethanol- HCl solution, arylamine-HCl and w=37% aqueous formaldehyde solution or the condensation product of arylamine and formaldehyde are directly reacted with ethyl 3-oxo-2-phenylmethylenebutyrate to form l-aryl-2-phenyl-3-carbethoxy-4-piperidone.

2－苯亚甲基－3－丁酮酸乙酯与芳香胺和w＝37％甲醛水溶液或芳胺和甲醛的缩合物在氯化氢－无水乙醇存在下可直接发生的Mannich反应，得到1－对位取代芳基－2－苯基－3－羰乙氧基－哌啶－4－酮。

Were synthesized by Knoevenagel condensation between substituted-3-formylchromone and barbituric acid or thiobarbituric acid in solid phase without solvent and catalyst.

在无溶剂无催化剂条件下，取代-3-甲酰色酮与巴比妥酸通过固相 Knoevenagel缩合反应合成了一系列5-(取代色酮基-3-亚甲基)巴比妥酸，收率68。

Were synthesized by Knoevenagel condensation between substituted-3-formylchromone and barbituric acid or thiobarbituric acid in solid phase without solvent and catalyst.

在无溶剂无催化剂条件下，取代-3-甲酰色酮与巴比妥酸通过固相 Knoevenagel 缩合反应合成了一系列5-(取代色酮基-3-亚甲基)巴比妥酸，收率68.0%~85.5%，其结构经1H NMR确证。

I am accused of being overreligious," she said in her quiet, frank manner,"but that does not prevent me thinking the children very cruel who obstinately commit such suicide.""

客人们在卡罗利娜·埃凯家里，举止就文雅一些，因为卡罗利娜的母亲治家很严厉。

Designed by French fashion house Herm è s, this elegant uniform was manufactured in our home, Hong Kong, and was the first without a hat.

由著名品牌 Herm è s 设计，这件高贵的制服是香港本土制造，是我们第一套不配帽子的制服。