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Results Stable drug-resistant SW1990/GZ cell strain was established by culturing with gemcitabine for 9 months. The morphology and growth characteristics of the cell strain changed remarkably. The cells shrinked and became rounder; its endoplasm expanded; granular substances increased; and the doubling-time was prolonged. Resistance of the cell line to gemcitabine, fluorouracil, adriamycin, and mitomycin significantly increased. The TrxR activity of the drug-resistant cells was increased markedly.

结果 药物培养9个月后,得到稳定传代的SW1990/GZ耐药细胞株;其形态学、生长特征等均发生了明显变化,细胞变圆、体积缩小、内质网扩张、颗粒样物质增多及细胞倍增时间延长;对吉西他滨、5-氟尿嘧啶、阿霉素和丝裂霉素的耐药性均显著增加;耐药细胞的TrxR活性也明显增高。

The influences of the shock thickness and Alfven waves on the particle acceleration by diffusive shock waves are numerically studied through solving one-dimensional diffusive equation including the second-order Fermi effect. It is shown that the spectral index of the energetic particles strongly depends on the shock thickness. For example, the spectral index increases from 2.1 to 3.7 in the low energy range of 3-10 MeV and from 2.5 to 5.0 in the high energy range of 20-60 MeV as the thickness increases. The spectral index decreases from 4.3 to 3.1 as the particle injection energy increases. The spectral index decreases from 4.0 to 1.8 at the quasi-steady stage with the enhancement of the compression ratio from 2 to 4. The results indicate that under the influence of Alfven waves, the energetic particle spectrum at lower energy becomes flat and the spectral index decreases from 2.5 to 0.6 in the low energy range of 3-10 MeV and from 11.6 to 5.0 in the high energy range of 20-60 MeV. At the same time, the rollover energy reaches 19.6 MeV. The spectral index decreases from 5.8 to 2.9 as the energy density of Alfven waves increase. All these results are basically consistent with the theoretical models, as well as the observations of typical energetic particle events.

通过数值求解包含二阶费米加速的一维扩散方程,探讨在准平行激波条件下激波厚度和级联阿尔芬波对粒子加速的影响,研究粒子分布函数的演化与激波厚度和阿尔芬波强度的内禀关系,计算结果表明:(1)考虑激波厚度时,谱指数明显依赖于激波厚度,随着厚度从0.32增大到2.56,低能端(3-10MeV)谱指数逐渐从2.1增加到3.7,高能端(20-60MeV)谱指数从2.4增大到5.0,能谱逐渐变软;当初始注入粒子动量增大1.3倍,质子能谱指数从4.3减小到3.1,且与零厚度激波加速的谱指数差值缩小;厚度不变时,随着压缩比从2增加到4,准稳态分布时低能端(3-10MeV)粒子能谱指数逐渐从4.0减小到1.8谱变硬;(2)在级联阿尔芬波的影响下,随着时间的增大,粒子在低能处(3-10MeV)的谱指数从2.5减小到0.6高能端(20-60MeV)谱指数从11.6减小到5.0,能谱变硬,拐点能量值从7.5MeV增大到为19.6MeV;随着波的能量密度增大,谱指数从5.8减小到2.9,这表明阿尔芬波强度越大,加速效率越高,通过与激波厚度解析结果和高能粒子事件的观测能谱比较发现两者是一致的,说明数值模拟结果是可靠的。

Learn to live with uncertainty and then you won't need to shrink the sphere of your activities and interests in order to entomb yourself in certainty.

学习在不确定你不会再缩小范围,你需要和利益的活动为了让自己埋藏确定性。

The wound tissue necrosis rate of the trial group and the control group <25% in two weeks were 32(96.9%) and 8(27.59%) respectively, and wound complete debridement rates were 90.91% and 6.70%. Wound area reduction rates were 47.42% and 20.21%.There was a significant difference between the two groups (P<0.05~0.01). It suggests that collagenase can promote granulation form and epithelization.

结果表明,治疗组和对照组两周内创面组织坏死率<25%的例数分别为32(96.9%)和8例(27.59%);创面完全清创率分别为90.91%和6.70%;创面面积分别缩小47.43%和20.21%,均具有明显差异(P<0.05~0.01),同时也表明,胶原酶对创面肉芽的形成和上皮化具有明显的促进作用。

Results Compared with control group, the wound area and wound volume at different day in rhaFGF group were significantly diminutedP<0.05), the healing rate was predominantly eleva Ted (P<0.05), the healing time was significantly shortenedP<0.05). RhaFGF resulted in a remarkable enhancement of granulation tissue growth and epithelization in wound.

结果:与生理盐水对照组比较,rhaFGF组伤后各时间点的创面面积、伤腔容积均明显缩小﹙P<0.05﹚,愈合率显著提高﹙P<0.05﹚,创面愈合时间明显缩短﹙P<0.05﹚。rhaFGF组的肉芽组织生长及再上皮化明显加速。

The results showed that the equilibrium conversion of toluene and trimethylbenzene decreased as temperature increased, and the equilibrium concentration of xylene decreased as ...

比较了β沸石催化剂上此体系在不同空速和温度下的化学反应产物组成与平衡组成,升高温度有利于缩小化学反应与平衡的差距。

An algorithm of eliminating the correlation of synthetic indexes based on index equivalence class is proposed in terms of Dijkstra algorithm. The reduction ranges of evaluation indexes can be reduced, and the anterior reduction results are used to increase the efficiency.

借鉴Dijkstra算法,提出了基于指标等价类的合成指标动态约简算法,即通过等价类划分来缩小参与约简的指标范围,并充分利用前一次约简以求得最终指标约简的结果。

Due to equivalent transformation during the simplification procedure of equations, the solution set of equations can neither expand and nor contract, and also the transformed equations for four displacement functions are compact in the form and easy to find their solutions.

由于方程化简过程是等价变形,从而可以保证方程的解集既不会扩大也不会缩小,而位移势函数便给出了一维六方准晶中弹性解的一个通解公式。

Methods makes Preoperation , locating approximately new nipple position and redundant breast skin range. In operation ,reshaping unfinished breast shape and locating new nipple2areola position finally in near erective position , breast is reducted using inferior pedicle technique. Results From August ,1995 , 34 cases were performed using this method.

术前对新乳头位置和乳房多余皮肤切除范围按下蒂法初步定位,术中在近似直立的体位下对初步形成的乳房再进一步的调整定位,最后确定新乳头乳晕的位置,然后采用下蒂法完成乳房缩小术。

Ergotamine causes temporary narrowing of blood vessels throughout the body, and therefore is not prescribed to those with poor circulation.

麦角胺的原因暂时缩小血管整个机构,因此不是明向那些与穷人的流通。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

聚光:照片上是建在西班牙桑路卡拉马尤城的一座新型PS20塔式太阳能电站。被称为&日光反射装置&的镜子将太阳光反射到主塔,然后用聚集的热量产生蒸汽进而通过涡轮机转化为电力