缠结

BACKGROUND: One of the key neuropathological changes in Alzheimer disease is that neurofibrils over phosphorylated cytoskeletal protein composed of entwist together, and the phosphorylation of τ protein can be catalyzed by cyclin dependent kinase 5 (CDK5),however whether the phosphorylation of neurofilaments can be catalyzed by CDK5, as well as its role in the pathogenesis of Alzheimer diseases is less acknowledged.

背景：阿尔茨海默病的主要神经病理学特征之一是由过度磷酸化的细胞骨架蛋白如(o，神经细丝组成的神经原纤维缠结，细胞周期蛋白依赖性蛋白激酶5可催化蛋白的磷酸化，但神经细丝是否可被细胞周期蛋白依赖性蛋白激酶5磷酸化及其在阿尔茨海默病发病中的作用却知之甚少。

In the aggregation process of polymer chains, when the time scale for the chain impenetration is far shorter than that for the chain collision, the polymer chains will aggregate to form spherical clusters.

对于高分子单链的聚集而言，当链贯穿的时间尺度远小于链碰撞的时间尺度时，链在聚集时就会相互缠结形成球形的聚集体。

With long, soft, entangled hairs; lanate.

具绵状毛的 Woolly 具缠结的长软毛；绵状毛的。

The amounts and morphon of pyramidale, the neurofibrillary tangle and senior plaque were observed.

通过组织病理学观察大鼠海马CA1区锥体细胞的数量和形态及神经元纤维缠结和老年斑等。

This element, even in low quantities, can create neurofibrillar tangles that occur in Alzheimer's and other mental degenerative diseases in the brain.

这一因素，即使在低量可以制造神经纤维缠结发生在阿尔茨海默症和其他精神退行性疾病中的脑。

In a series of 300 brain autopsies, 18 cases were diagnosed as Alzheimer 's disease with 10 male and 8 female average age 71.2 years(61 to 86) and courses of disease 0.5 to 6 years. All of them presented some degree of intellectual impairment. The clinical symptoms Progressed gradually. Pathologically, in all cases brain atrophy (mild degree in 6 cases, moderate degree in 8 cases and severe degree in 4 cases)was observed.Microscopically large amount of senile Plaques and neurofibrillar...

在连续300例尸检脑标本中，筛选出60岁以上18例Alzheimer病，占6％；病程6个月～6年，均表现不同程度的智能障碍。18例病理检查见重度脑萎缩4例，中度8例，轻度6例；镜下于脑叶皮质和海马区见大量老年斑及神经原纤维缠结，8例海马区有颗粒空泡变性。18例脑皮质神经元均明显减少，与对照组比较差异有非常显著性（P＜0.0001）。11例AD并存有淀粉样脑血管病。

DESIGN: Senile plaques and neurofibrillary tangles were assessed quantitatively in 97 cases from 7 Alzheimer's Disease Centers. Neuropathological diagnoses of AD were also made with four sets of criteria.

设计：评估来源于7个阿尔茨海默氏病中心的97名患者的老年斑和神经纤维缠结情况，之后进行四套标准阿尔茨海默病的神经病理学诊断评估。

Methods OA was injected into hippocampal CA1 region of rats. We observed rat praxiology changes by Morris water maze and the senile plaques and neurobrillary tangles of hippocampus by Bielschowsky stain and the expression of β-amyloid protein and neuronal nitric oxide synthase of the rats hippocampus by immunohistochemistry.

在大鼠海马CA1区多次微量注射OA，水迷宫实验观测大鼠行为学改变；Bielschowsky染色观察海马CA1区神经原纤维缠结和老年斑等特征性病理变化；免疫组化方法观察海马CA1区Aβ1-40和nNOS的表达。

The purpose of a story is to sound an alarm, to keep a light trained on the System in order to prevent it from tangling our souls in its web and demeaning them.

情节的目的听起来是一种警报，是对体制进行光芒的训练，阻止它将我们的灵魂缠结在它的圈套中，防止践踏我们的灵魂。

The purpose of a story is to sound an alarm, to keep a light trained on the System in order to prevent it from tangling our souls in its web and demeaning them.

情节的目的听起来是一种警报，是对体制进行光芒的培训，阻止它将我们的灵魂缠结在它的圈套中，防止践踏我们的灵魂。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。