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This invention is directed to a stable liquid pharmaceutical formulation comprising a high concentration, e.g. 50 mg/ml or more, of antibody in about 20-60 mM succinate buffer or 30-70 mM histidine buffer, having pH from about pH 5.5 to about pH 6.5, about 0.01-0.1% polysorbate, and a tonicity modifier that contributes to the isotonicity of the formulation.

本发明涉及一种稳定的液体药物制剂,该制剂含有:pH约5.5-6.5的约20-60mM的琥珀酸缓冲液,或30-70mM的组氨酸缓冲液;约0.01%-0.1%的聚山梨酯;和能增强该制剂等渗性的渗透修饰剂,以及高浓度如50mg/ml或以上的抗体。

The main content of the dissertation is designing and realizing the total scheme and frame of system software. The module of the input and output is designed by using the generally I/O of the multichannel buffered serial port to simulated the communication of I~2C bus. The Ping-Pong buffer is brought forward to resolve the problem of the data rate matching. The logic switch function is designed in the programmed logic devices. The data transmission rate is improved by using the DMA and the dual buffer mechanism. The system program self-loading is realized by the design of the self-leading program. Lastly, the dissertation analyzes the characteristic of LLL video and experimentalize with some typical image processing algorithm.

主要对系统软件的总体方案与框架结构进行设计实现,内容包括利用通用串行口模拟I~2C通讯实现输入/输出模块的设计,提出乒乓缓冲结构来解决数据的速度匹配问题,利用可编程逻辑器设计完成逻辑切换控制功能,利用DMA并行传输方式并设计双缓冲结构提高数据的传输速度,设计自引导程序来实现系统程序自加载,最后深入探讨了微光视频图像的特征说明了几种典型的微光图像处理算法的原理,参考这些处理算法设计能在高速视频图像处理器上实现的软件方法,并做了一部分相关的实验研究。

It is discovered that the longitudinal stiffness of this new type buffer bow is less than that of conventional bow structures, and the new type buffer bow can absorbed more energy when collision finished. This new type buffer bow can also obviously reduce the damage of struck shipside in collisions.

另外本文从船艏内部结构形式出发设计了一种新型间断甲板式的缓冲型船艏结构,研究发现这种新型的缓冲船艏的纵向刚度小于传统的船艏结构,碰撞结束时新型船艏结构能够吸收更多的能量,并且能够明显减小对被撞船侧的损伤。

The factors relevant to the running buffer and their effects on separation were investigated. The buffer solution composed of 30 mmol/L sodium borate and 2.4 mmol/L β-CD was found to be the most suitable electrolyte for separation. The second order dissociation constant range of honokiol was estimated. The content range of honokiol in Cortex Magnoliae Officinalis and was 3.42-5.98 mg/g, while the mean content of honokiol in its preparation 0.021 mg/mL.

优化了厚朴提取物的分离条件,考察了缓冲溶液浓度、pH 值、β-CD的添加浓度对分离的影响,确定了最佳的分离缓冲溶液组成为30 mmol/L 硼砂和2.4 mmol/L β-CD,pH 值为9.48;推测出和厚朴酚的二级离解常数pKa2 的范围为9.94-10.83;在优化的分离条件下,测定了厚朴药材和藿香正气口服液中和厚朴酚的含量分别为3.42-5.98 mg/g、0.021 mg/mL,和厚朴酚的线性范围是0.020-0.405 mg/mL,其线性相关系数R=0.998(n=5),加样回收率为98.4-103.5%,RSD 为3.2-5.7%(n=3)。

To investigate the pitting and metastable pitting rules of type 304 stainless steel, potentiodynamic polarization method was employed to study the behavior of metastable pitting and stable pitting on 304 stainless steel in sodium bromide solution and borate/phosphate buffered bromide solutions. The influence of the concentration of Br-、the pH value、the buffer capacity and general environmental factor to pitting potential and metastable pitting was studied as well.

为了更深入地了解304不锈钢的稳态及亚稳态孔蚀规律,本文采用动电位慢扫描法测得了304不锈钢的阳极极化曲线,研究了不锈钢在纯溴化钠溶液及含溴化钠的硼酸盐或磷酸盐缓冲溶液中的亚稳态孔蚀以及稳态孔蚀行为,分析了溴离子浓度、pH值、缓蚀性阴离子、以及缓冲容量和综合环境因子对孔蚀电位以及亚稳态孔蚀特征参数中的形核数目、峰值电流、生长寿命的影响。

Briefly, coronal brain sections (100 mm)were cut with a vibratome, postfixed with 4% glutaraldehydein 0.1 mmol/L cacodylate buffer (pH 7.4) for 1 h, andthen with 1% osmium tetroxide in 0.1 mmol/L cacodylatebuffer for 2 h. After rinsing with distilled water, the brainsections were treated with 1% aqueous uranyl acetateovernight, dehydrated in an ascending series of ethanolsto 100%, followed by dry acetone, and then embedded inDurcupan ACM. Ultrathin sections (0.1 mm) were cut andstained with 3% lead citrate and subsequently examinedwith a Zeiss transmission electron microscope (Zeiss Inc.,Thornwood, NY, USA).

简单的说,先用切刀制成100um的冠状脑切片,然后用含有4%戊二醛在0.1 mmol/L的二甲砷酸缓冲液(PH7.4)中固定1小时后,放在含有1%四氧化锇的0.1 mmol/L的二甲砷酸缓冲液中2小时,接着用蒸馏水冲洗后,放在1%的aqueous uranyl acetate中过夜,接下来用梯度酒精(至100%)脱水,然后用丙酮干燥,再用Durcupan ACM包埋,切成0.1um的超薄切片后用3%的lead citrate染色,随后用透射电子显微镜观察。

The procedure of the analysis is as follows :first,the digital road map was made based on the paper map ofFangshan,southwest Beijing,andthefire distribution map was made byinputingthefire points collected withGPSinto the GIS.The road connectivity was obtained using the Axwoman to drawlines along the roads.Buffers onthe lines within a distance of 1 000m were made,and the curver fitting was analyzed between the fire numbers and the road connectivity.

首先对房山区的纸质地形图进行扫描,制作房山的道路分布专题图,并将GPS采集的林火火点位置转入ArcView GIS,制作林火火点位置图;用Axwoman扩展模块勾绘了道路,进行了道路连通度的分析,并以勾绘的连通线作了1 000 m的缓冲分析;以连通度与相应的缓冲区内的林火火点数作了拟合分析。

The method comprises: when the sending end receives a high priority SDU from upper layer, the fragmentation, cascade connection and filling are made for the high priority SDU to form HPDU, and then the HPDU is inserted in front of the PDU already completing the fragmentation, cascade connection and filling, and not yet sent out; based on the head expansion type or the length indication, a PDU is determined as a HPDU; in addition, establishing a buffer, and inputting the value of LI ah HE into the buffer; after all HPDUs of a same SDU are collected, a SDU is recombined and is sent to upper layer.

一种无线链路控制层发送确认模式交织协议数据单元的方法,在发送端收到上层高优先级SDU时,将该高优先级SDU进行分片、串接、填充处理形成HPDU,插入到已经完成分片、串接、填充处理但尚未发送的PDU前,使用HE或LI长度指示标识HPDU,实现优先发送HPDU;在接收端接收下层PDU,根据PDU中的头扩展类型HE或者长度指示LI判断为HPDU;另外开辟缓冲,根据长度指示LI和HE值将HPDU中的数据放入该缓冲;同一SDU的所有HPDU收齐,重组成SDU向上层投递。

Based on the traffic model of a single node and on the system stability criterion, it is shown that the PD controller can regulate the source rate on the basis of the knowledge of buffer occupancy of the destination node in such a manner that the congestion-controlled network is asymptotically stable without oscillation in terms of the buffer occupancy of the destination node.

在单个节点的交通流的模型基础上,运用控制理论中系统稳定性分析方法,讨论如何利用信终端节点缓冲占有量的比例加微分的反馈形式来调节信源节点的能控交通流的输入速率,从而使被控网络节点的缓冲占有量趋于稳定。

After an interrupt is generated, the CPU compares the interrupt number (x8) against the size of the IDT -- stored in the interrupt descriptor cache register. If the INT# x 8 doesn't exceed the IDT size, then the interrupt is considered invokable, and the IDT base address is fetched from the descriptor cache; then the ISR's protected mode address is fetched from the IDT.

在产生一个中断之后, CPU 将会把中断号(乘以8)和 IDT 的长度进行比较( IDT 的长度存储在中断描述符缓冲寄存器中),如果中断号乘以8之后的值没有超过 IDT 的长度,则该中断被认为是可调用的,然后将 IDT 的基址从中断描述符缓冲寄存器中取出; ISR 的保护模式帝制从 IDT 中取出。

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My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻,也许正是在通往天国的路上,我体验着这白色的晕旋。

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