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The dose-response curve of histamine was shifted parallely to the right. pA2 was 9.34±0.61. The guinea-pigs were effectively reduced the rate of histamine induced death, decreased reaction extent of shock (P<0.01) and prolonged latency period of shock (P<0.05) by orally administered cetirizine ranged from 0.1, 0.2 and 0.4 mg.kg-1. The capillary permeability to intracutaneous injection of histamine was potently inhibited by orally administered cetirizine ranged from 0.0625 to 0.25 mg.kg-1 in mice, blue area obviously decreased (P<0.01), and dose-response curve existed obviously. In which the effect of these dosage groups were superior to the group of chlorphenamine.

结果:西替利嗪3×10-8~3×10-7mol.L-1可剂量依赖性地对抗组胺引起的肠肌收缩,使组胺的量效曲线平行右移,pA2为9.34 ± s 0.61,西替利嗪0.1,0.2及0.4 mg.kg-1口服给药时,能明显减轻豚鼠静脉注射组胺所致休克反应的严重程度(P<0.01),并可延长豚鼠惊厥反应的潜伏期及降低死亡率(P<0.05),西替利嗪0.0625~0.25 mg.kg-1口服给药可显著对抗组胺引起的小鼠皮肤血管通透性的增高,使蓝染面积显著缩小(P<0.01),且存在明显的量效关系,3个剂量组的作用均优于氯苯那敏组。

The intranasal route of drug administration is feasible and promising.

鼻内给药是一种可行的有前途的给药途径。

One week after administration of lead acetate and cadmium chloride, the numbers of NOS-positive IC reduced significantly.

给予醋酸铅和氯化镉1周后,NOS阳性的睾丸间质细胞数量明显减少,并随给药时间延长而加重,NOS活性逐渐降低,给药4周后NOS阳性的睾丸间质细胞几乎不着色。

Methods 40 healthy adult mice were randomly divided into control group, CTX immune-suppressed group, Fb treated group, Fb combined with CTX treated group. The influences of Fb in NK cell activity were determined by the method of NK mediated cytotoxicity test;the multiplicative capacity of lymphocyte was assayed by lymphocyte transformation rate of T cell,and the mice spleen T lymphoblast multiplication analytical method was used to measure the IL-2 level.

健康成年小鼠40只,随机分为对照组、环磷酰胺免疫抑制组、黄蘑碱溶性多糖活性组分正常小鼠给药组和Fb环磷酰胺伍用给药组,采用NK细胞介导的细胞毒试验测定自然杀伤细胞的活性,淋巴细胞转化试验测定T淋巴细胞增殖功能,鼠脾T淋巴母细胞增殖分析法测定白细胞介素2(IL-2)的活性,观察Fb对各组小鼠免疫指标的影响。

After treatment for 4 weeks, the parameters, including blood glucose, glycosidase, maltase, total cholesterol, triglyceride, were determined.

复方中药糖脂清各剂量组,给药前与给药4周后相比各剂量组均可降低血糖,同时降低KK-Ay小鼠小肠的蔗糖酶与麦芽糖酶的活性、血清中总胆固醇和甘油三酯的含量。

The level of blood fat was tested after lavaged for four weeks. Results VOFA did not improve the condition of DM rats, but it could control marasmus of DM rats. The effect of decreasing blood glucose was appeared since lavaged 2 weeks, and the effect was obviously after late lavaged one hour, the effect of high dose was significant. The level of total cholesterol was decreased in VOFA group, and other indicators had no significant changes.

结果 VOFA未见明显改善DM大鼠的整体状况,但可控制其消瘦,并且从给药第2周开始表现出明显的降糖效果,在末次给药后1 h可以明显降低血糖值,均以高剂量组为著;同时,DM大鼠出现血脂紊乱,VOFA能明显降低其总胆固醇水平,对其余指标无显著影响。

Results At test potential of +60 mV, NMB 0.1,1,10 μmolL^(-1) activated I from (33.62±2.00) pApF^(-1) to (35.68±1.87),(42.9±2.73) and (59.36±1.39) pApF^(-1)(n=6 cells from 6 rats ,P.01), respectively.

结果 指令电位为+60 mV时,N-甲基小檗胺0.1,1,10 μmolL^(-1)使I幅值分别由给药前的(33.6±2.0)pApF^(-1)增至给药后的(35.7±1.9),(42.9±2.7)和(59.4±1.4)pApF^(-1)(n=6,P.01)。

Methods According to the relevant references,the character and application of the ophthalmic drug delivery systems were summarized.

根据文献综述了眼部给药剂型及给药系统的特点和应用。

Osteitis fibrosa is a manifestation of sencondary hyperparathyroidism.

动物实验已经证实,PTH对骨代谢具有双相作用,即间歇给药促进成骨,而大剂量持续给药则促进骨吸收。

RESULTS: Melatonin significantly reduced the anxiety scores from 5, 3.5-6 to 3, 2-3 after premedication and to 3, 2-3.5 during surgery (P = 0.04 and P = 0.005 compared with the placebo group, respectively).

结果:褪黑素显著降低焦虑评分。给药前中位数及四分位数间距为5, 3.5-6。给药后中位数及四分位数间距为3, 2-3,术中为3, 2-3.5(P=0.04并且和分别和对照组相比 P=0.005)。

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