给药

By using Morris Maze task,The results indicated the learning and memory impairment was continuously maintained by MA-induced neurotoxity,PF_(11) significantly antagonized the learning and memory impairment by MA-induced neurotoxicity, Motor incoordination was studied by using the rotating rod method in mice,PF_(11) markedly alleviated the injury induced by MA.using HPLC-ECD,there were markedly decrease the contents of DA,DOPAC,HVA and 5-HIAA,PF_(11) markedly antagonised decrease of DA in MA-induced neurotoxicity.

在Morris水迷宫空间辨别性学习记忆实验中，甲基苯丙胺中毒小鼠找到平台的潜伏期明显延长，PF_(11)沈阳药科大学硕士学位论文中文摘要能显著缩短延长的潜伏期。转棒实验表明，甲基苯丙胺中毒小鼠运动协调性显著降低，而PF；；能桔抗小鼠运动协调性的降低。甲基苯丙胺中毒小鼠大脑内多巴胺及其代谢产物DOPAC、HVA含量明显降低，另外，5一羟色胺的代谢产物5－HIAA明显降低，而PF；；与甲基苯丙胺联合给药小鼠大脑内DA、HVA的含量显著升高。这些结果提示PF；通过影响多巴胺神经系统而桔抗甲基苯丙胺神经毒性的作用。

The protocol of this research would be carried out as follows: to evulate effects of sodium ferulate on experimental colitis model of rats induced by acetic acid and investigate its mechanism; to evulate effects of sodium ferulate on experimental colitis model of rats induced by trinitrobenzene sulfonic acid with ethanol and investigate its mechanism.

我们在建立乙酸、三硝基苯磺酸(2，4，6-trinitrobenzene sulfonic acid，TNBS)两种经典大鼠结肠炎模型的基础上，采用灌肠给药方式来观察阿魏酸钠对这两种大鼠实验性结肠炎的作用效果，进而从不同角度对其有关机制进行探讨，以期为阿魏酸钠成为IBD有效治疗药物的开发应用提供实验依据。

The results of this reseach showed that administration of SF intracolonically had protective effect on the colon injury in the rat model of colitis induced by acetic acid enema, which was probably due to the mechanism of antioxidation, inhibition ofarachidonic acid metabolis and platelets activation, administration of SF intracolonically also showed protective effect on the colon injury in the rat model of colitis induced by trinitrobenzene sulfonic acid and ethanol, which was probably due to antioxidation and inhibition of macrophages activation.

实验研究表明，大鼠分别经乙酸、TNBS和乙醇处理后均出现典型的结肠炎症状，给药后分别评价结肠粘膜损伤指标、结肠组织病理变化，检测结肠组织炎症指标、结肠组织氧化损伤指标及主要炎性细胞因子改变；实验结果：阿魏酸钠对大鼠乙酸性结肠炎结肠粘膜损伤具有缓解保护作用，其机制可能与直接抑制炎症结肠粘膜花生四烯酸代谢过度，抑制血小板活化，清除大量氧自由基有关；阿魏酸钠对大鼠TNBS性结肠炎粘膜免疫损伤亦具有缓解保护作用，其机制可能与抗氧化，抑制结肠巨噬细胞活化有关。

The blood was centrifuged and the plasma and buffy coat were discarded.

稳定性测试是通过大鼠静脉给药法和HPLC法，分别观察EDDF对血压的影响及在HPLC上的保留时间和积分面积的变化； 3。

The therapeutic effects were monitored and the costeffectiveness analysis was conducted.

目的：比较三种给药方案治疗儿童下呼吸道感染的疗效及成本效果。

The accompanying drawing diagrammatically illustrate an applicator for use with compositions of the present invention.

附图用图解法阐明了与本发明之组合物一起使用的给药器。

The optimal time for combination of radiosensitizers and radiotherapy will be determined from the significant difference of uptake and retention between the tumor and the major normal tissues. The biodistribution obtained from organ removal and counted by gamma scintillation counter was similar to that obtained from autoradiography.

本研究利用加马闪烁计数器与自动放射摄影术两种方法，探讨分别或同时使用[131I] IUdR、[18F] FMISO在肿瘤及正常器官的摄取状况、清除速率及生物分布，找出此两种药物在肿瘤中积聚最多的时间点，并与其他正常器官有明显的差别，以期应用在临床上病人给药的依据。

Also provided are its pharmaceutical formulations and methods of administration.

还提供了它的药物制剂和给药方法。

General condition, haematology and biochemical tests, electrocardiogram, urine test, visceral dissection and coefficient and histopathology were performed.

结果： 给药期高剂量组的犬间断性出现呕吐，且摄食量减少，血清总胆红素明显升高，白蛋白降低，胸腺和脾脏的系数值有一定升高。

Results:Osteoblasts has the ability of transmembrane transport of metformin. The transport of metformin could be saturable with time and drug concentration adding;a certain range of temperature and pH can promote the transport of metformin;The transport of metformin was inhibited by cimetidine and phenformin,but promoted by verapamil;Oct1 but no Oct2 was expressed extensively in cell membrane and cytoplasm of osteoblasts;The protein level of Oct1 can be up-regulated by metformin with different drug concentrations and times,but no obvious differentces from each group.

结果：二甲双胍能够在成骨细胞上进行跨膜转运，且随着转运时间和药物浓度的增加而增加，并可达到饱和；一定范围内提高温度和pH值可以促进二甲双胍的转运；西米替丁和苯乙双胍对二甲双胍转运有明显抑制作用，而维拉帕米则对转运有明显的促进作用；Oct1广泛表达在成骨细胞的胞膜及胞浆中，而Oct2无表达；二甲双胍在不同浓度及不同给药时间均能够上调Oct1的表达，但各组间无明显差别。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了