给药

OBJECTIVE: To establish a method of dosage regimen design of multiple dosing extravenous administration of one-compartment model.

目的：建立一种简便的一室模型血管外多次给药的方案设计方法。

After dosing, serial blood samples were collected for a period of 72 h.

给药后，连续采集血样至72 h。

Objective To study the influence factors of the preparation of emulsified isoflurane agent, the quality control of, the optimum concentration and equivalent as well.

目的 研究乳化异氟醚静脉制剂的配制的影响因素、质量控制，最佳浓度的筛选以及与吸入给药的生物等效性。

Hemoglobin was effectively encapsuled into alginate microspheres by improved electrostatic droplets generation, which would he a foundation not only for forming uniform controlled release membrane around the microsphere surface but also for preparing protein-loaded microspheres with size ≤10μm for oral administration.

采用静电液滴工艺实现了蛋白质在海藻酸盐微球中的高效包封，为在微球表面形成均匀控释膜、制备粒径≤10μm蛋白质药物的口服给药微球载体奠定了基础。

Each male ratwas paired with 2 female rats in proestrus when administration terminated. Femalerats were examined the next morning for the presence of sperm in vaginal smears andunderwent a cesarean section on day 13 of gestation. Then the reproductive indiceswere calculated as follows: copulation index, pregnancy index, and fertility index,which can evaluate male fertility directly. The sperm motility and morphology wereevaluated by computer-assisted sperm analysis, moreover, the caudaepididymal sperm ultramicrostructure were analyzed by transmission electronmicroscope, which can evaluate the influence on sperm maturation bydutasteride ; sperm survival rate was assessed by SYBR-14 and propidium iodidefluorescent staining; serumal dihydrotestosterone and testosterone of ratswere detected by enzyme-labeled immunoassay, which can evaluate the effecton androgenic levels; the weights of testes and epididymides, were determined byprecise electronic balance; histological examination of above tissues were evaluatedby HE staining and TEM, which can evaluate treatment on histology of reproductiveorgans by dutasteride.

给药结束后雄鼠与处于动情前期的雌鼠按2：1合笼，计算雌鼠的交配指数、受孕指数和生育指数，直接评价雄鼠生育力；采用计算机辅助精子分析系统分析大鼠附睾精子活力和形态，在此基础上合并使用透射电镜技术对各组附睾尾部精子进行透射电镜分析，评价度他雄胺对大鼠精子成熟的影响；采用SYBR-14和propidium iodide双重荧光染色计算精子存活率；采用Elisa法测定大鼠睾酮(testosterone， T)和双氢睾酮(dihydrotestosterone， DHT)血清浓度，评价度他雄胺对雄鼠雄激素水平的影响；采用精密电子天平对各组睾丸、附睾、前列腺和精囊进行称重，评价度他雄胺对大鼠生殖器官重量的影响；采用HE染色法对各组睾丸和附睾进行组织学分析，同时采用透射电镜技术对附睾上皮细胞超微结构进行分析，评价度他雄胺对大鼠主要生殖器官组织学的影响。

Methods: A total of 21 young swines were randomly divided into untreated group, low-dose salvianolate group and high-dose salvianolate group (7 in each group). AMI was induced by ligaturing left anterior descending coronary artery. After the operation, 400 or 200 mg salvianolate dissolved in 250 mL 5% glucose saline was administered by intravenous drip to swines in the HS group and the LS group respectively for 7 days. The swines in the untreated group were administered with 250 mL 5% glucose saline.

苏中幼猪21只，随机分为模型组和低、高剂量丹参多酚酸盐组。3组均经开胸结扎冠状动脉左前降支制作心肌梗死模型，造模成功后当日，高剂量丹参多酚酸盐组给予400mg丹参多酚酸盐加250mL 5%写葡萄糖生理盐水静脉滴注；低剂量丹参多酚酸盐组给予200mg丹参多酚酸盐加250mL 5%葡萄糖生理盐水静脉滴注；模型组给予等体积的5%葡萄糖生理盐水静脉滴注。1次／d，连续给药7d。

There are many new parenteral products, including anti-infectives, biotechnology derived products, and in-vitro diagnostics which are manufactured as lyophilized products.

一些新的非肠道给药产品，包括抗感染药物、生物技术起源的药物、诊断药物采用冻干的方法生产。

The mental state was meliorated simultaneously,and the serum IL-2, IL-6 and cortisol levels in the depression model mice were decreased significantly compared with normal mice.

自拟舒肝解郁灵和百忧解给药21 d后，小鼠体重降低有所改善，精神状态改善，血清中IL-2、IL-6及皮质醇含量降低，明显低于生理盐水组（P.01）。

After 4 and 10 days,observe the effect of Ainsliaea fragrans Champ on EGF expressed of cervix mucosae of rats of different dose group,and analyzed its pathomorphology.

方法建立大鼠宫颈炎动物模型，分别于给药4天、10天后观察杏香兔耳风不同剂量组对大鼠宫颈粘膜表皮生长因子表达的影响，并进行病理组织学检查。

We made the model of myocardia ischemia/reperfusion injury in rat by ligating the LAD for 30 minutes and followed reperfusion 60 minutes.

1、结扎大鼠冠脉左前降支造成急性心肌缺血模型，经股静脉给药。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。