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In contrast, the average concentration of 5-FU in the portal vein in animals receiving intraperitoneal injection of 5-FU was 20.67μg/ml 15 minutes after injection and was indetectable 24 hours later.

腹腔化疗组给药后15min门静脉血5-Fu浓度达20.67μg/ml,但持续时间短,24h后浓度极低。

Methods The antipyretic activity of SMPS was observed in rats with high temperature induced by dried yeast and 2,4-dinitrophenol; biliary duct cannula bile at 0.5,1,1.5,2,2.5 h after intraduodenal administration in rats was collected and counted to observe the effect of SMPS on biliary secretion;the weight of cholecyst in mice was counted to observe the effect of SMPS on the cholecyst of mice;the acute toxicity test of SMPS was done with mice.

采用干酵母、2,4二硝基苯酚致大鼠发热的模型观察玉米须多糖的解热作用;采用胆管引流法分别收集并计量给药后0.5,1,1.5,2 ,2.5 h的胆汁的方法观察SMPS对肝脏分泌胆汁的影响;采用测定小鼠胆囊重量的方法观察SMPS对胆囊的影响;对SMPS进行了小鼠急性毒性实验。

MethodsThe antipyretic activity of SMPS was observed in rats with high temperature induced by dried yeast and 2,4-dinitrophenol; biliary duct cannula bile at 0.5,1,1.5,2,2.5 h after intraduodenal administration in rats was collected and counted to observe the effect of SMPS on biliary secretion;the weight of cholecyst in mice was counted to observe the effect of SMPS on the cholecyst of mice;the acute toxicity test of SMPS was done with mice.

目的研究玉米须多糖的清热利胆作用及急性毒性。方法采用干酵母、2,4二硝基苯酚致大鼠发热的模型观察玉米须多糖的解热作用;采用胆管引流法分别收集并计量给药后0.5,1,1.5,2 ,2.5 h的胆汁的方法观察SMPS对肝脏分泌胆汁的影响;采用测定小鼠胆囊重量的方法观察SMPS对胆囊的影响;对SMPS进行了小鼠急性毒性实验。

MethodsThe antipyretic activity of SMPS was observed in rats with high temperature induced by dried yeast and 2,4-dinitrophenol; biliary duct cannula bile at 0.5,1,1.5,2,2.5 h after intraduodenal administration in rats was collected and counted to observe the effect of SMPS on biliary secretion;the weight of cholecyst in mice was counted to observe the effect of SMPS on the cholecyst of mice;the acute toxicity test of SMPS was done with mice.

方法采用干酵母、2,4二硝基苯酚致大鼠发热的模型观察玉米须多糖的解热作用;采用胆管引流法分别收集并计量给药后0.5,1,1.5,2 ,2.5 h的胆汁的方法观察SMPS对肝脏分泌胆汁的影响;采用测定小鼠胆囊重量的方法观察SMPS对胆囊的影响;对SMPS进行了小鼠急性毒性实验。

Methods: The coronary arterial arterial blood flow, cardiac output, left ventricular pressure, bloodpressure, myocardial oxygen consumption of dogs were recorded by the polygraph system before and after intraduodenal administration of TXL.

测定心肌耗氧量等心脏血流动力学指标。结果:通心络胶囊0.72g/kg剂量组,给药后45min冠状动脉血流量增加了21.56%,同时增加左室作功,与生理盐水组比较有明显差异(P<0.01)。

Objective To show the ambiguity observed in LD50 determination in mice obtained by intragastric administration of drugs.

目的 说明小鼠灌胃给药测定LD50的结果存在歧义性。

All the mice were administered via intragastric way per day for 4 weeks continuously.

各组小鼠每天灌胃给药一次,连续四周。

The LD50 of intragastric infusion and intra-peritoneal administration were 5.7 g/kg and 106 mg/kg.

通过灌胃给药和腹腔注射,测得LD50分别为5.7g/kg和106mg/kg。

Methods The effects of O325H were investigated in normal KM mice and two kinds of type 2 diabetic mice by intragastric garage.

灌胃给药,观察O325H对正常小鼠的糖耐量以及对两种2型糖尿病小鼠的降糖降脂作用。

This is known as "intrathecal drug delivery."

这就是被称作&鞘内给药。&

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这两个团体间的分歧难以掩饰。

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