给药

Objective To study the effects of sodium salicylate on ultrastructure and hearing response properties of inferior colliculus neurons in mice.

目的探讨水杨酸钠给药对小鼠下丘核神经元超微结构及听反应特性的影响。

Methods The rat's colonitis was induced by 8% acetic acid.Twenty hours later,the rats were given the medicine and the hair color and stool had been observing for two weeks.

8%的醋酸灌肠大鼠建立溃疡性结肠炎动物模型，24 h后给药，连续14天，观察大鼠毛色、粪便、体重变化情况。

The sensitivity and protection mechanisms of the eye promote more effective drug delivery systems with better compliancy to be developed, however, the applications of numerous pharmaceutical methods are limited simultaneously, which presents great challenge in designing ophthalmic dosage forms.

眼睛的有效保护机制与高度敏感性促使人们探索开发安全合理的给药系统，同时又限制了许多药剂学手段的应用，为此类剂型的设计带来了极大的困难。

The coturnix artherosclerosis model was established by feeding with high-fat diet (1% cholesterol, 14% lard, 6% bean oil) and treating it with Yizhikang simultaneously, observing whether serum TC, TG, LDL-c, HDL-c, VLDL-c, liver lipidoses and AO artherosclerotic plaque were resulted at.

用高脂饲料（1%胆固醇，14%猪油，6%豆油，剩余加入基础饲料）喂养复制鹌鹑动脉粥样硬化模型并同时给药，观察益脂康对其血清TC，TG，LDL-c，HDL-c，VLDL-c，肝脏脂质沉积和主动脉粥样硬化斑块形成的影响。

Methods Myocardial ischemia was induced by subcutaneous injection of ISO (30 mg/kg for two days, once a day). The experimental animals were randomly divided into the normal group, ISO group, positive control group and three crocetin groups (25, 50, 100 mg/kg). Cardiac indexes were examined. The level of LDH, CK, MDA in serum were measured. The content of MDA, GSH-Px and the ATPase activity heart and mitochondria were assayed by colorimetric analysis. The histopathological change of myocardia was investigated by HE staining.

采用大剂量ISOsc诱导产生大鼠急性心肌缺血模型(1SO30mg／kg，每日一次，连续2d)，实验大鼠随机分为正常组、ISO模型组、阳性对照组和3个西红花酸给药组(25，50，100mg／kg)，测定心脏系数和血清中乳酸脱氢酶、磷酸肌酸激酶和丙二醛含量，观察心肌组织谷肮甘肤过氧化物酶、Na^ ，K^ —ATP酶和Ca^2 ，Mg^2 —ATP酶活性及心脏病理改变，观察西红花酸的保护作用。

Studies on stability indicated that PHGF proliposomes should be stored at low temperature and against light, which ensured unchange of their redispersity, content of drug, encapsulation efficiency, acid value and peroxide value. Liposomes were multilamellar vesicle structure under transmission electron microscopy. Average particle size was 0.65 micrometer, ranging from 0.09 micrometer to 1.21 micrometer. Cryoscopic value was 0.64 C determined by cryoscopic method, which was a little higher than that of isotonic solution.

以透射电镜观测PHGF前体脂质体再分散后的形态为囊泡状；激光散射法测得平均粒径为0.65μm，且粒度分布在0.09μm～1.21μm之间；该脂质体荷负电，ζ电位为-44.23mV；冰点降低法测得冰点降低度数为0.64℃，略高于等渗溶液冰点降低度数；测得粘度为1.83mPa·s，达到生理要求；此外，对PHGF脂质体的刺激性、溶血性、热原、异常毒性和过敏沈阳药科大学硕士学位论文拘要性检查表明均符合静脉注射给药的标准。

Methods Sample dosages were used 15mg,20mg,25mg/ by gstro gavage.The conrulsion rates was induced by maximum electric shock,ip cardiazin mice and lateral intracereral injection of curine in rats were observed.

方法采用克癫胶囊251、5、20mg/灌胃给药，观察最大电休克致小鼠惊厥率和筒箭毒碱侧脑室注射致大鼠惊厥率及戊四唑诱发小鼠惊厥的抗惊厥作用。

The curative effects of supplementary treatment with therapeutic instrument administering drug cutaneously on ALRI of children were very obvious,especially for this kind of patients who mainly had moist rales and wheezing as pulmonary signs (the markedly effective rate on the third day was 30.3%).

治疗组在入院第2日予经皮给药治疗仪辅助治疗3日，并给予随机所附肺炎贴片(处方：柴胡、黄芩、板蓝根、川贝、生大黄、白芥子等，具有宣肺解表、止咳平喘、理气化痰的功效)。

In order to increase the stability and hence increase the oral antiinflammatory activity, and as well as to de- crease or abolish the anticancer activity of type I com- pounds, an alkyl group was incorporated into the side chain of cyclopentanone Mannich base to generate type Ⅱ compounds.

为提高化合物的稳定性以使化合物经口给药时具有抗炎活性，同时降低或消除抗癌活性，本文将Ⅰ类化合物的Mannich碱侧链部位引入烷基而设计并合成了Ⅱ类化合物（共18个）。

Exposure to metoprolol, a substrate of CYP 2D6, was increased by 30% when it was given in combination with gefitinib (500 mg daily for 28 days ) in patients with solid tumors.

在实体肿瘤患者中将药物代谢酶 CYP2D6的底物美托洛尔与吉非替尼（500毫克/天，服用28天）同时给药，则吉非替尼的药效升高30%。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。