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Miltiorrhiza depside salts in beagle dogs, the high AUC was obtained for LSB with a steady high concentration in blood during the infusion. 3. Pharmacokinetics of S.

静脉滴注丹参多酚酸盐的给药方式下,丹参乙酸的药时曲线下面积明显高于同剂量下静脉注射或皮下注射方式的AUC,丹参乙酸在滴注给药期间维持稳定的峰浓度。

This paper is mainly comprised of two components:preparation of models of rats suffering from deficiency of spleen Yang;comparison of the pharmacodynamics impacts of different Lizhong Pills formulations made up by dried ginger or its different components in Lizhong Pills to the different groups of the models.1 Establish the model of deficiency of spleen YANG induced by " cypsum fibrosum and anemarrhenae " with complex factors1.1 ObjectivesWith using heat-clearing and fire-purging drug cypsum fibrosum and anemarrhenae,insteading of the common usage of rhubarb and folium sennae,accompanied with irregular diet and overstrained,the model of deficiency of spleen-YANG is to be established,which is much close to the pathopoiesis theory of " frigidity and chilly damaging yang,irregular diet injuring qi,overstrain impairing the spleen" in TCM.1.2 MethodsModel rats is fully fed every other day,given the molding drug of cypsum fibrosum -anemarrhenae(concentration 4:1) with 3 different frequency,and arranged to swim everyday in 25℃water until exhausted(performing as spitting bubble 3 times continuously or sinking unable to float by itself).

全文共分为脾阳虚模型的制备和干姜及其成分对理中丸药效学影响的比较两大部分。1"石膏-知母"复合法脾阳虚模型的制备1.1目的以清热泻火药石膏-知母代替常用的大黄、番泻叶类苦寒泻下药,并结合饥饱失常、劳倦过度的方法进行造模,以期建立更符合中医"寒凉伤阳、饥饱伤气和劳倦伤脾"致病思路的中医脾阳虚证候模型。1.2方法模型动物隔日足量喂食,每日在25℃水中游泳,直至大鼠连续三次吐泡下沉,或沉入水底,3秒内不能自行浮出水面,并以三种不同给药频率灌胃给予石膏一知母煎液,比较石膏-知母不同给药方法对制备脾阳虚模型的影响。

The enantioselective degradation and pharmacokinetics of ethofumesate enantiomers in rabbits were investigated by a single intravenous administration at doses of 30 mg kg~-1 of racemate.

以大白兔为试验动物,采用静脉注射外消旋体的给药方式,考察了给药后不同时间点的血药浓度以及脑组织、肝脏和胆汁中左右旋体的残留量。

All rats were enforced intragastric administration of equivalent dose for 3 days. 1 hour and 2 hours later after the last intragastric administration, the serums of the G ranula of P enetrating Bone and Removing Pain were separated. Then we interfered in the obtained BMSCs for 72 hours with the serums from different density, and investigated the effect of the G ranula on proliferation of the BMSCs.(3) The second generation BMSCs were randomly divided into 3 groups, i.e.

给予相对应的给药量灌胃3d,末次给药分别在1小时﹑2小时后进行采血,制备透骨消痛颗粒含药血清,运用透骨消痛颗粒不同含药血清浓度对获得的BMSCs进行药物干预72h,通过MTT法研究透骨消痛颗粒对BMSCs增殖的影响。

Results: No significant difference were found befween A and B or C and D group before administration of TMP. In compare with the control group, TMP might increse HR and CO but decrease BP. The most marded changes of BP and CO appeared immediately agter the administration of the drug and refurned to the same leoel as premedication 5-7min later. The ± LVdp/dtmax and Time- tenson- index decreased firstly and increased later, reached the peak at 5min. In AMI group no obvious changes was found in HR. but BP decreased and CO increased.

注药前各监测指标在A、B两组及C、D两组间均无显著性差异,与A组相比,TMP可使健康大鼠出现明显的HR增快,BP下降,以及CO的增加,BP和CO改变的最大值均出现在给药即刻,5~7分钟内逐渐恢复至给药前水平,±LVdp/dtmax和时间一张力指数为先降后升,5分钟时达最高峰;在AMI大鼠组,TMP对HR无明显改变,但出现BP下降和CO增加,对±LV dp/dt max和TTI只有短暂的抑制,l~3分钟后恢复至用药前状态,无增强作用。

The results showed that①the fos like immunoreactionwas increased in the rat frontal cortex,cingulate cortex,islands of Calleja and caudate putamen in the acute group;②the FLI was increased in the rats frontal cortex,mammillary nucleus,amygdaloid nucleus and caudate putamen in the chronic group;③...

结果显示:1一次给药后额叶皮质,扣带回,嗅结节岛,纹状体四个部位的免疫反应阳性细胞数显著增加;2长期给药组额叶皮质,乳头体核,杏仁核和纹状体四个部位的 C- FOS免疫反应阳性细胞数显著增加;3不同抗抑郁药作用的部位有差异。

This paper is mainly comprised of two components:preparation of models of rats suffering from deficiency of spleen Yang;comparison of the pharmacodynamics impacts of different Lizhong Pills formulations made up by dried ginger or its different components in Lizhong Pills to the different groups of the models.1 Establish the model of deficiency of spleen YANG induced by " cypsum fibrosum and anemarrhenae " with complex factors1.1 ObjectivesWith using heat-clearing and fire-purging drug cypsum fibrosum and anemarrhenae,insteading of the common usage of rhubarb and folium sennae,accompanied with irregular diet and overstrained,the model of deficiency of spleen-YANG is to be established,which is much close to the pathopoiesis theory of " frigidity and chilly damaging yang,irregular diet injuring qi,overstrain impairing the spleen" in TCM.1.2 MethodsModel rats is fully fed every other day,given the molding drug of cypsum fibrosum -anemarrhenae(concentration 4:1) with 3 different frequency,and arranged to swim everyday in 25℃water until exhausted(performing as spitting bubble 3 times continuously or sinking unable to float by itself).

全文共分为脾阳虚模型的制备和干姜及其成分对理中丸药效学影响的比较两大部分。1&石膏-知母&复合法脾阳虚模型的制备1.1目的以清热泻火药石膏-知母代替常用的大黄、番泻叶类苦寒泻下药,并结合饥饱失常、劳倦过度的方法进行造模,以期建立更符合中医&寒凉伤阳、饥饱伤气和劳倦伤脾&致病思路的中医脾阳虚证候模型。1.2方法模型动物隔日足量喂食,每日在25℃水中游泳,直至大鼠连续三次吐泡下沉,或沉入水底,3秒内不能自行浮出水面,并以三种不同给药频率灌胃给予石膏一知母煎液,比较石膏-知母不同给药方法对制备脾阳虚模型的影响。

Mechanical and cold allodynia were observed at preadministration and 15, 30, 60, 90, 120, 150, and 180 min after drug administration and were quantified by measuring withdrawal frequencies to stimuli with von Frey filaments and 100% acetone, respectively.

给药前、给药后15、30、60、90、120、150、180分钟记录机械和冷异常,且经常用 von frey 细丝和100%丙酮分别刺激量化测量停药后反应。

The dogs were administrated with carboplatin at the dosage of 16.5mg/kg intravenously, intra-arterially or retroperitoneally. The blood samples were taken at 0, 5, 15 minutes, and 0.5, 1, 2, 4, 8, 24 and 72 hours after instillation. The competent platinum concentrations were measured with high-performance liquid chromatography. Then the pharmacokinetic parameters were calculated and analysed.

随机将18只雌性家犬分为3组,分别经静脉,动脉及腹膜后推注卡铂(16.5 mg/kg),然后于给药后的0、5、15分钟,0.5、1、2、4、8、24、72小时取静脉血,用高效液相色谱法测定血浆活性铂的浓度,计算和比较不同给药方式下卡铂的药代动力学参数。

Methods: One hundred and sixty SD rats were randomly divided into four groups (40 in each group), and orally given the medicine with doses of 50, 25, or 12.5 g/kg of crude drug, or with bean oil of 0.5%CMC-Na daily for 26 weeks.The physical status (body weight,growth rate and appetite), hematological parameters, blood biochemistry, blood cotting, organ index, and tissue pathological changes of rats were checked in the 13th week,and 26th week of the administration and in four weeks after the stop of the administration.

160只SD大鼠,随机分为高、中、低剂量组及空白对照组,雌雄各半,每日灌胃1次,连续给药26周,观察大鼠的一般状况、体重、摄食量和给药13、26周及停药后4周大鼠的血液学、血液生化学、凝血功能、脏器系数、解剖学及病理组织学改变的情况。

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