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Results The results showed that:(1) Only fluoxetine could decrease the 5-HT immunoreaction in cornu ammonis and thalamas in rat brain in the acute group;(2) Four antidepressant drugs could decrease 5-HT immunoreaction in six regions of rats brain in the chronic group.

结果 ①一次给药后,仅氟西汀降低大鼠海马和丘脑5-HT免疫反应性;②长期给药组中,4种抗抑郁药均能降低大鼠额叶、海马、丘脑、脑干和小脑的5-HT免疫反应性。

Mice in control group were administered intragastricly at a dose 0.01 mL·g-1 for 10 d;PL were administered intragastricly for 10 d;CTX were administered parenterally every other day for 10 d.

空白对照组每日灌胃给予蒸馏水0.01 mL·g-1;CTX为隔日腹腔注射给药;PL为每日灌胃给药,连续给药10 d。

The first-way shows that the virus can be inactivated firsthand by the flavonoid compound; The second-way shows the flavonoid compound can inhibit virus replication by inhibiting the activity of ptyalin; The third-way reflects the flavonoid compound can interdict adsorption.

第一种给药方式说明黄酮类化合物可以直接灭活H5N1病毒;第二种给药方式说明黄酮类化合物可通过抑制流感病毒唾液酶的活性,从而抑制病毒粒子的复制;第三种给药方式反映一定浓度的药物可以阻断病毒对细胞的吸附作用。

Methods]By observing the cytoplasmic Ca2+ concentration change of single cardiocyte in I/R status and the effect of Na+/H+ permutoid retarder to Ca2+ concentration in different phases (diabetes pure oxygen-lack deficit group called DM group,the oxygen deficit/reaeration on entire journey for medicine group called DM-EIPA group, the first group giringmedicine before reaeration on called DM-EIPA 1 group, and the second group giringmedicine before reaeration on called DM-EIPA 2 group) to detect the protection mechanism of Na+/H+ permutoid retarder to diabetic mouse cardiac muscle cell oxygen deficit/reaeration injury.

方法] 通过观察糖尿病鼠单个心肌细胞在缺氧/复氧时细胞胞浆Ca2+浓度的动态变化以及Na+/H+交换体阻滞剂在不同时相(糖尿病单纯缺氧组即DM组,缺氧/复氧全程给药组即DM-EIPA组,复氧前给药1组即DM-EIPA 1组,复氧前给药2组即DM-EIPA 2组)对Ca2+浓度的影响来研究Na+/H+交换体阻滞剂对糖尿病鼠心肌细胞缺氧/复氧损伤的保护机制。

The embedding catheter rats were fixed point injecting vaccine, once per day for 15 days with microsyringe of microdialysis device.

给药组用微透析仪的微量进样器匀速定点给药,每日给药1次,连续15天。

He activity of y-GT also had dose- dependent and time-dependent effect and became lowest on day 7 at the concentration of 0.5 and 1.0 umol/L. The activity of TAT increased. On day 4, the cells treated with 0.25, 0.5 and 1.0 umol/L of As2O3 had higher activity compared with control group (P.05) and it continued afterwhile.

AT随着各给药组时间的延长而上升,并随给药剂量增大而上升程度更大,培养第4天,0.25 μmol/L浓度的亚砷酸组TAT的比活性较对照组高(P<0.05),0.5 μmol/L、1 μmol/L浓度的亚砷酸组TAT的比活性较对照组更高(P<0.01),以后各天给药组均高于对照组(P<0.01)。

Methods: By using microelectrode technique the action potentials on guinea pig papillary muscle AP(subscript PM and AP on sinuatrial node AP(subscript SN were induced and the effects of Zaoboniug granula on AP and AP were observed.

豚鼠20只分为早搏宁冲剂组(n=10)与盐酸普鲁卡因胺组(n=10), 2组均采用累积浓度给药给药,常规微电极技术引导豚鼠心室乳头肌快反应动作电位AP(下标 PM。另取豚鼠16只分为早搏宁冲剂组(n=10)与盐酸普鲁卡因胺组(n=6),同法给药、引导窦房结优势起搏细胞动作电位AP

METHODS: We randomized 42 healthy parturients in early laborto receive 0.1% ropivacaine + fentanyl 2 g/mL eithervia PCEA+BCI (n = 21,bolus 5 mL, lockout 10 min, basal infusion5 mL/h) or via PCEA+AMB (n = 21, patient-activated bolus of5 mL, lockout 10 min, basal automated boluses of 5 mL/h [omittedif a patient-activated bolus was successfully administered inthe last 1 h]) after successful induction of combined spinalepidural analgesia.

我们将42名处于早期产程的健康娠妇女在成接受腰硬联合镇痛后,随机分为两组,一组接受 PCEA+BCI (n = 21,单次给药5ml ,锁定时间 10分钟,背景剂量5 mL/h),另一组接受 PCEA+AMB (n = 21,患者自控单次给药5 mL,锁定时间 10 分钟,背景剂量自单次给药5ml/h),两组均给予0.1%的罗哌卡因+太尼2 g/mL 。

aim: to determine a reasonable clinical administration protocol by comparing the changes of clonazepam concentrations in rat brain and serum following single and repeated dose administration of czp.

目的:研究氯硝西泮单次给药和重复给药后血清及脑组织药物浓度的变化,寻找合理的给药方案。

Results Eye drops,eye ointments and eye pellicles are applied widely in the ophthalmic therapy. The ophthalmic drug delivery system such as in situ-forming gels drug delivery system,colloidal drug delivery system,microspheres and implants can improve the bioavailability of drug apparently.

结果 目前滴眼剂、眼膏、眼用膜剂广泛应用于治疗眼病,眼部给药系统如原位凝胶给药系统、胶体给药系统、微球、植入剂等可以明显地提高药物的生物利用度。

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