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Result: Xinhuang Tablet had very significant inhibition on acute and chronic inflammation in model of ear edema induced by croton oil in mice, paw swelling induced by carrageenin in rats, granuloma induced by cotton pellet in rats and very significant analgesic effect on thermal and chemical stimulation in model of writhing body response induced by acetic acid in mice and tail flicking in rats.And at the same doses, Xinhuang Tablet hadn't significant difference from ig administration.

结果:新癀片外涂给药对小鼠耳肿、大鼠角叉菜胶足肿、棉球肉芽肿等急、慢性炎症有非常显著的抑制作用;对大、小鼠水浴甩尾、小鼠醋酸扭体等温热刺激、化学刺激引起的疼痛有非常显著的镇痛作用,且在相同剂量下,外涂给药和ig给药的作用无明显差异。

By the experiments of simulating gastrointestinal tact environment in vitro and pharmacodynamics on rats comparing administration with clyster and oral way, it is proved that components in common preparation of Kangfuxin are demolished in gastrointestinal tract and not able to arrive at colon in integrity with oral administration.

通过体外模拟胃肠道试验,及灌肠给药与口服普通制剂给药的药效学试验,证明康复新普通制剂在胃肠道环境中,其主要成分会被破坏,无法口服到达结肠病变部位进行治疗,局部给药能使药物发挥较好的疗效。

The observing parameters of OAA/S scores, BIS, BP, HR, SpO2, theoretical and actual times of pushbutton by the patient and the patient's satisfaction were recorded on seven time-points include before PCS, 5min after PCS, esophagoscope introducing, Oddis sphincter dissecting, bile duct imaging, end of procedure and recovery period.

记录给药前、给药5min、内窥镜插入食管、Oddis括约肌切开、造影、术毕、苏醒期七个时点的OAA/S镇静评分、脑电双频指数值、BP、HR、SpO2及病人按压次数和实际给药次数,以及病人对使用PCS的满意程度。

Another 72 mice were randomly divided into control group,egg yolk model group,Expellant and Cleanning Fat Capsule 0.4 g·kg-1 group,CFB 10.0,5.0,2.5 mL·kg-1 groups (n=12).Mice in each group were exhibited once a day for 10 d.16 h before the last administration,except control group,the mice in other groups were injected with 75% yolk physiological salt solution 0.5mL through the abdominal cavity,and began to starve,1 h after the last administration, the contents of serum TCHO and TG were determined,and liver MDA level was measured.

另取小鼠72只随机分为空白对照组、蛋黄模型组、排毒清脂胶囊0.4 g·kg-1组及CFB 10.0、5.0和2.5 mL·kg-13个剂量组( n=12),每天给药1次,连续 10 d,末次给药前16 h 除空白对照组外,所有各组小鼠每只均腹腔注射75%蛋黄生理盐水溶液0.5 mL,并且开始饥饿;末次给药后1 h测定血清TCHO及TG含量,取肝脏测MDA含量。

Methods: At first,a kind of implantable transfusional pumps for chemotherapy were made,and were implanted in the body of rabbits.5-Fu was inputted slowly and continuously into musculature or hypodermis,when any rabbit died,the varieties of pathology were detected.

自制植入式化疗给药泵装置,并植入实验兔体内,将5-Fu持续、直接释放于兔子的肌肉和皮下组织内,设立自身两侧对照,不同时间取材,病理检验给药与非给药后的组织改变,统计评价两者之间的差异。

The effects of combinations of iv physostigmine and ith morphine were more pronounced at early postoperative time. The potency of low dose combination was significantly greater than that of double doses of both drugs. The ﹪ MPE of the observed effects of all combinations was significantly higher than that of the expected additive effects.

结果:毒扁豆碱术后1~3 h静注导致﹪MPE明显提高;毒扁豆碱与吗啡的联合给药效应在术后早期更明显;小剂量联合给药的镇痛作用明显大于双倍剂量单独给药的镇痛作用;联合给药的测得效应值明显大于估计叠加效应值。

To produce medicine serum of Liu-Shen-Wan with different dose, different time of pouring medicine, different time of blood sampling.2. To measure content of arsenic in serum with atomic absorption method, to qualitative analysis toadfish in medicine serum of Liu-Shen-Wan with thin layer chromatography.3. MTT and trypan blue assay detects the growth inhibition effect of Liu-Shen-Wan on HL-60 cells and to make certain the best scheme of making method of medicine serum of Liu-Shen-Wan.4. Gimsa dying assay observes morphology changes of apoptosis .In situ end-labeling method and flow cell machine quantificationally probes apoptosis phenomena.

1 分不同的给药剂量、给药天数和不同的采血时间制备含药血清。2 用原子吸收法测定血清砷含量;薄层色谱法定性检测六神丸含药血清中蟾酥成分。3 用MTT法、胎盘蓝染色法观察六神丸对HL-60细胞的增殖抑制作用,确定最佳血清制备方案。4 用吉姆萨染色法观察细胞凋亡的形态学变化,流式细胞仪、原位末端标记法定量检测细胞凋亡程度。

Blood samples were collected at 0, 5, 10, 15, 30, 45 minutes and 1, 1.5, 2, 3 hours after the drug was given. Serum concentrations of penicillin G were determined by microbiological method. A computer program was used to determine the pharmacokinetic parameters for the blood concentration- time data by compart...

以电子计算机程序处理血药浓度—时间数据,血药浓度随时间变化符合二室开放模型,所得主要动力学参数为:分布半衰期(t1/2α)0.14±0.03h;消除半衰期(t1/2β)0.70±0.21h;表观分布容积0.696±0.141 l/kg;体清除率11.67±1.02 ml/;药时曲线下面积21.57±1.93h·IU/ml,本文还根据单剂量给药参数推算给药方案,供兽医临床参考。

Results: DNA content of the plasmodia not treated with any drugs was not changed in 24 hours,while benflumetol could decrease the DNA content: the DNA content began to decrease 2 h after the drug administration and reached the minimum by 16 h, but somewhat increased at 24 h after administration.

结果:对照组疟原虫DNA含量在各时间点没有显著变化。本芴醇单次给药后,随时间推移疟原虫DNA含量逐渐减少,药后2 h两给药组疟原虫红内期 DNA含量开始降低,到16 h降到最低,但药后24 h DNA含量又有所回升。

At the end of the experiment, all of the rats were killed after the last time when the rats were treated with medicine. And the serum was collected to observe blood picture, function of liver kidney, and other important organs were observed, too. The other half number of the rats was killed in two weeks when the rats were stopped taking medicine.

实验结束时分两批处死动物,第一批于最后一次给药后24小时处死,每组处死动物的1/2,作为给药期的观测,取血测血象及肝肾功能,取重要脏器作组织病理学检查;第二批将余下的动物于停药后继续饲养2周后处死,作为恢复期观察,与给药期作相同指标的检测,以了解毒性反应的可逆程度和可能出现的延迟毒性反应。

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