给药

Methods (1) The influence on the rats with non-bacterial prostatitis of 1.5% carrageenin. Rats were divided randomly into the normal control group, the model control group, the Qianliean low-dose group (1.5 g/kg), mid-dose group (3.0 g/kg), high-dose group (6.0 g/kg), with 10 rats in each group. All groups were treated continuously for 7 days, once a day. The model control group was given distilled water, 30mins after the last medication, injects 1.5% carrageenin 0.05ml in each rat's prostate, after 24hs, behead execute the rats and record the white blood cell number and Lecithin density.(2) the influence on the swelling ears of rats.

方法(1)对1.5%角叉菜胶致大鼠非细菌性前列腺炎的影响：将大鼠随机分为正常对照组、模型对照组、前列安颗粒小剂量组（1.5 g/kg）、前列安颗粒中剂量组（3.0 g/kg）、前列安颗粒大剂量组（6.0 g/kg）及阳性药前列舒乐颗粒组（2.4 g/kg）6组，每组10只，各给药组大鼠连续灌胃给药7日，每日1次，模型对照组给予等容量蒸馏水，末次给药后30 min，在每鼠前列腺内注入1.5%角叉菜胶0.05 mL，24 h后断头处死大鼠，取致炎前列腺组织，镜下记录白细胞数和卵磷脂小体密度。

Objective To conduct Pharmacodynamics research of Qianliean pellet and provide the basis for the clinical medication. Methods (1) The influence on the rats with non-bacterial prostatitis of 1.5% carrageenin. Rats were divided randomly into the normal control group, the model control group, the Qianliean low-dose group (1.5 g/kg), mid-dose group (3.0 g/kg), high-dose group (6.0 g/kg), with 10 rats in each group. All groups were treated continuously for 7 days, once a day. The model control group was given distilled water, 30mins after the last medication, injects 1.5% carrageenin 0.05ml in each rat's prostate, after 24hs, behead execute the rats and record the white blood cell number and Lecithin density.

方法(1)对1.5%角叉菜胶致大鼠非细菌性前列腺炎的影响：将大鼠随机分为正常对照组、模型对照组、前列安颗粒小剂量组（1.5 g/kg）、前列安颗粒中剂量组（3.0 g/kg）、前列安颗粒大剂量组（6.0 g/kg）及阳性药前列舒乐颗粒组（2.4 g/kg）6组，每组10只，各给药组大鼠连续灌胃给药7日，每日1次，模型对照组给予等容量蒸馏水，末次给药后30 min，在每鼠前列腺内注入1.5%角叉菜胶0.05 mL，24 h后断头处死大鼠，取致炎前列腺组织，镜下记录白细胞数和卵磷脂小体密度。

The notable proliferation was not observed by eyes in the local of injection. The infiltration of inflammation cells and mild proliferation of fibrocyte around dura mater was observed by HE stained in 4 and 8 weeks after injection. Infiltration and exudation of inflammation cells was observed by HE stained in epidural nerve root. Compared with group A, no changes of group B, C and D were observed under specific stained. Proliferation of type Ⅱ collagen fibers around dura mater was seen under immunohistochemical stained in 4 and 8 weeks after injection. There is no significant demyelination changes under LFB stained. The thickness and shape of the myelin sheath in epidural nerve root was not regular under transmission electronic microscopy in 4 and 8 weeks after injection. Fibroblast was also seen there. In nerve endometrium, macrophage could be seen under TEM, myelinated nerve fiber changed significantly, but nonmyelinated nerve fiber changed mildly. When 8 weeks, the changes of group D is smaller than the group B and C.

给药局部肉眼观察未见明显的纤维组织增生；HE染色可见B、C、D三组给药后四周及八周时硬膜内外均有炎细胞浸润，纤维细胞轻度增生，硬膜外神经根内有炎细胞浸润及炎性渗出；特殊染色B、C、D三组同A组相比未见有脊髓及神经根的改变；免疫组化染色，给药后四周及八周时，硬膜内外均有Ⅱ型胶原纤维增生；固兰染色B、C、D三组未见有明显脱髓鞘改变，与A组相比无明显异常改变；电镜观察B、C、D三组在给药后的四周及八周时，表现为硬膜外神经根内髓鞘厚薄不一，形状不规则，可见成纤维细胞，神经内膜中可见有巨噬细胞；粗大的有髓神经纤维变化明显，无髓神经纤维受累较轻；八周时电镜下D组改变较B、C两组为轻。

Results:Normal rats as the donator of serum, using methanolic extract of CWC, 10 times equivalent dose for adults every day, intragastric administration twice a day of 8-hour interval, keeping on 3 days, hemospasia after 2 hours of the last administration was the better preparative method of the serum containing drug. Adding 10% of this serum to culture system could elevate hepatocyte increment and depress ALT in cell culture medium significantly.

结果：每天以成人等效剂量10倍的甲醇提取物间隔8h分两次给正常大鼠灌胃给药，连续3天，末次给药后2h采血制备含药血清比较合理，体系中加入10%该条件下制备的含药血清能明显提高损伤肝细胞的增殖能力、降低细胞ALT泄漏。

We ascertain primary auditory cortex by recording the sound-induced reaction, then we stimulate white matter with electrode current, inducing and recording LTP in layer II /III.

结果发现：关键期给药组、成年给药组的LTP幅度增长百分数显著性小于正常组的LTP幅度增长百分数；关键期给药组LTP幅度增长百分数显著性小于成年给药组的LTP幅度增长百分数。

In the long-period toxicity test, DCG was administered repeatedly for 60 days, the dose were 72.6,36.3,18.2 g/kg respectively(It refered to the dose of material,which amounted to 52.6,26.3,13.2 times of 50 kg human clinic use). There is no other abnormal changes about color patem,action,urine and stool,but cibation, hydroposia, body weight and index part of hematological and hematobiochemical parameters,coefficient and histomorphological figure of organs were examined during administration phase.The rats were examined in 21 days after the cessation of DCG, the abnormal changes of index was completely recovered.

定喘颗粒大鼠给药60 d的毒性试验，剂量分别为72.6，36.3，18.2 g/kg（相当于临床50 kg人用量的52.6，26.3和13.2倍），给药期间各组大鼠毛色、活动、二便均无异常变化，但给药组大鼠摄食、饮水、体重以及部分血液学、血液生化学指标和脏器系数有异常变化，停药后，上述异常变化指标均已恢复正常。

Results: Tyroserleutide can significantly increase the life span of H22 tumor-bearing mice by 50-70% in dosages of 20ug/kg/d-80ug/kg/d,specially the high dosage of 80ug/ml can significantly increase the life span by 69.24%; Tyroserleutide can inhibit the growth of transplanted hepatocellular tumor BEL-7402 in nude mice,the rate of tumor inhibition was25-50% in dosages of 40-320ug/ml ,the inhibition rate of 160ng/ml was 44.03%; Tyroserleutide could inhibit the growth of H22 and BEL-7402 tumor in a dose-dependent manner. Simultaneously, tumoricidal activity of tyroserleutide against BEL-7402 cell line in vitro was observed hinger when compared with the control group(P.05).The inhibition effect of 72hrs was higher than 24hrs,48hrs,96hrs.And specially the high dosage of 160ug/ml can significantly inhibit growth of tumor cell by 19.36%. Tyroserleutide can activated PEM and marked enhance cytotoxicity andphagocytosis functions in vitro and in vivo. The OD values of cytotoxicity were observed hinger when compared with the control group(P.05).The cytotoxicity of macrophages activated by tyroserleutide against BEL-7402 and B16-F10 was 35.58%,61.2% in vitro and21.39%,47.63% in vivo. The cytotoxicity rate of nude mice PEM was 32.86%,73.07% in vivo. Furthermore, tyroserleutide alone could stimulated the production of IL-1B TNF- a and NO by M . Tyroserleutide and LPS could synergistically activated M producing more cytotoxicity effectors. Conclusion: Tyroserleutide had inhibition functions against hepatoma carcinoma .Its possible mechanisms were related to the affect that Tyroserleutide could inhibit tumor cell directively and induce tumor cells apoptosis or death effectively.

结果：酪丝亮肽能显著延长腹水型肝癌H_(22)小鼠的生存时间，给药剂量为80μg／kg／d时疗效最显著，达到69.24％，在20μg／kg／d-80μg／kg／d剂量范围内生命延长率为50-70％，给药剂量与荷瘤鼠生存时间呈现一定量效关系；酪丝亮肽能显著抑制人肝癌BEL-7402移植瘤裸鼠的肿瘤生长，给药剂量为160μg／kg／d时疗效最显著，抑制率为44.03％，并且在40-320μg／kg／d剂量范围内抑制率为25-50％，给药剂量与肿瘤抑制率呈现一定量效关系；酪丝亮肽体外对人肝癌BEL-7402细胞生长有一定的抑制作用，在作用72hrs时各浓度酪丝亮肽对肿瘤细胞的抑制作用较24hrs、48hrs、96hrs明显，其中浓度为100μg／ml时抑制率达19.36％；酪丝亮肽体内外均能增强小鼠腹腔巨噬细胞对肿瘤细胞的杀伤：体外作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与效应细胞对照组相比有显著性差异(P＜0.05)杀伤率分别达到35.58％、61.2％；体内作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P 。05)，杀伤率分别达到21.39%、47.63%；裸鼠腹腔巨噬细胞经酪丝亮肤作用后对BEL一7402、B 16一F10杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P.05)，最高杀伤率分别达到32.86%、73.07%；酪丝亮肤能增强单核巨噬细胞系统的吞噬功能，吞噬指数与生理盐水组比较有显著性差异(P.05)；酪丝亮肤体外作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与效应细胞对照组相比有显著性差异(P.05)；酪丝亮肤体内作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与生理盐水对照组相比有显著性差异(P.05)；酪丝亮肤能促进鼠巨噬细胞株R戌W264.7分泌合成IL一1p和NO，IL一1日、NO水平分别在酪丝亮肤作用24hrs、12hrs时达到高峰，酪丝亮肤单独应用能提高巨噬细胞的分泌合成功能，而且酪丝亮肤能与LPS协同作用刺激巨噬细胞的细胞毒效应分子分泌合成。

Methods: 40 cases received the defibrase treatment. The initial dose of defibrase basis on plasma FIB level, the rechallenge time and dose are regulated according to the plasma FIB level , keeping the plasma FIB within 0.5～1.3g/L for one week.

对40例脑梗塞患者使用降纤酶治疗，治疗组给药方法：首次给药根据血浆FIB水平调整给药剂量，再次给药根据血浆FIB 水平调整降纤酶的使用剂量及使用时间。

Methods The mice were intragastrically administered with Wikstroemia Liquid for 90 days continuously. The doses of Wikstroemia Liquid were 60 times, 30 times, 15 times as human daily doses. The mice condition, major hematological indexes, blood biochemical and organ pathological tissues changes were observed during medicine administration, at the end of medicine treatment and resuscitation stage after medicine treatment.

取复辣液分别相当于人日用量的60倍、30倍、15倍，经90天小鼠灌胃给药，观察给药过程中、给药末期及停药恢复期动物的一般状况，主要血液学、血液生化学和脏器病理组织变化。

The B, C, D group each mouse right armpit department hypodermic vaccinates the H22 lump cell to hang fluid 0.2ml, after vaccinating 24h weighing, and starts the abdominal cavity injection to give the medicine: A, B group uses physiological saline 0.2ml/only (continuously to give medicine 14 days) every day, C group with 5 fluorine uracil mg/day, dilutes the density is mg/0.2ml (the 1~5th day for medicine), D group will put down with the physiological saline disappears the hitch to compound mg/only (continuously to give medicine 14 days).

依据随机化原则，将40只ICR雌性小鼠随机分为四组，分别为空白对照组，荷瘤对照组，5氟尿嘧啶组，平消栓组。B，C，D组每只小鼠右腋部皮下接种H22瘤细胞悬液0.2ml，接种24h后称重，并开始腹腔注射给药：A，B组每日用生理盐水0.2ml/只（连续给药14天），C组用5氟尿嘧啶25mg/kg（第1~5天给药），D组用生理盐水将平消栓配制成1.0g/kg（连续给药14天）。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了