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Arsenic could be detected in the main organs and tissues of rats after administration of a single dose. The arsenic was most accumulated in the spleen, hair, lung and suprarenal gland organs, and kidney, heart, liver, bladder and skin came next. Brain, testis, muscle and tibia had the least amount of arsenic. After 15 continuous days of administration, arsenic contents in kidney and bladder tissues increased appreciably besides suprarenal gland, lung, hair and spleen.

单次给药后,在大鼠各主要脏器、组织中均可检测到砷,以脾、毛发、肺和肾上腺中分布较多,肾、心、肝、膀胱、皮肤次之;大脑、睾丸、肌肉、胫骨中分布较少,多次给药后砷除了同样在肾上腺、肺、毛发和脾分布较多外,在肾和膀胱的积累显著增加。

2Treatment study : The hepatic fibrosis models were induced by CCL4 for eight weeks by the same method, then treat them with extract of Achillea millefolium L .

治疗研究:造模方法同预防研究,1-8周造模,第9周开始给药治疗,灌胃剂量和方法同预防研究,共给药治疗6周。

Objective To study the effect of different doses of levodopa on the flash visual evoked potential of form-deprived amblyopic rats, and to discuss the possible mechanism of amblyopic therapy.

30只14日龄SD大鼠幼鼠,随机分为3组,每组10只,分别为弱视对照组、小剂量给药组及大剂量给药组。3组SD大鼠采用单眼睑缝合30 d建立形觉剥夺眼弱视模型。

The median patient age was 41 years, 1 female and 3 male. The patients received BMSCs infusion at a dose of (1.0-2.0)×107 cells every time by intrabone marrow injection from the anterosuperior iliac spine and BMSCs from the same donor for the same patient were infused more than once.

骨髓间充质干细胞髓内注射具体方法:取右髂前上棘为穿刺注射点,注射骨髓间充质干细胞悬液,4例患者的给药剂量基本控制在(1.0~2.0)×107个细胞/次,行间断多次给药

At the same time the pathological examination was made on aorta artery.results zexie grain decreased obviously the levels of serum tc, ldl and mda, increased the activity of sod, and decreased the area and thickness of athermanous plaque in experimental animals.

结果 泽泻颗粒高、低剂量组tc、ldl、sod给药前后差值与模型对照组比较差异均有统计学意义(p<0.05);泽泻颗粒低剂量组tg、hdl、mda给药前后差值与模型对照组比较差异均有统计学意义(p<0.05)。且泽泻颗粒低剂量组的主动脉内膜增厚程度及结缔组织成分均较模型对照组轻。

Methods 12 guinea pigs of 20 months with 3 cm×3 cm hair sheared from their backs were divided into control group and experimental group. Rhodosin and deer serum preparation was besmeared on the skin of guinea pigs in experimental group, and cosmetic matrix was besmeared on the skin of animals in control group for 60 d. The distribution of type Ⅲ collagen was observed with Sirius red staining and HE staining. The fission index of the cells of stratum basale, the thickness proportion of stratum corneum to epidermis, the volume density of the collagen fibers and small blood vessel in dermis, the number of fibroblasts in aging skin were meassured with technique of sterology.

背部被剪去3 cm×3 cm毛的12只20月龄豚鼠被随机均分为给药组和对照组,给药组涂抹红鹿制剂,对照组涂抹化妆品基质,连续涂抹60 d;应用天狼猩红、HE染色和体视学技术分别观察和测定老化皮肤中Ⅲ型胶原的分布、表皮基底层细胞的分裂指数、角质层同表皮厚度的比例、真皮胶原纤维和微血管的体密度和成纤维细胞的数目。

SAH was induced in the Sprague-Dawley rat by injection 0.3 ml of autologous blood into cisternal magna, following the second hemorrhage at 48 hours later.

我们设计诱导二次蜘蛛膜下腔出血模式,给药方式分两种,一是预防性给药,在蜘蛛膜下腔出血前两天开始投予;另一是蜘蛛膜下腔出血发生后开始投予。

Methods The procedure used autologous disc of the rats from the coccygeal intervertebral discs to impose direct pressure to the L5 dorsal root to induce an animal model of lumbar disc herniation. After the epidural tube was inserted, early prophylactic therapy and late remedial dexamethasone therapy were conducted to observed the PWMT of both hind paws of the rats.

取大鼠自体尾部椎间盘组织置于L5神经根下,建立椎间盘突出动物模型,然后硬膜外置管,采用早期预防性给药及晚期治疗性给药方法,观察地塞米松对大鼠后足底机械刺激疼痛阈值的影响。

It showed a dosage dependent degrease of blood glucose level. The effect after intestinal administration is better than it after oral administration.

比较口服经胃给药和肠道注入给药,发现胰岛素油溶液肠道注入后的降血糖效果更佳。

A clinical effective rate of 81.8% was obtained after treated with doxofylline for 1 week or 6 weeks,with a lung-function improve drate of 59.1% similar to those of sustained-released theophylline.

连续给药1周或4周,试验组临床有效率为81.8%。连续给药后PEF明显升高,肺功能改善有效率为59.1%。上述结果均与对照组相似。

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