结核

The synthesis of ethambutol hydrochloride used as an antituberculosis agent, was studied systematically in this paper, including the synthesis and resolution of-2-aminobutanol, racemization of-2-aminobutanol and the recovery of L--tartaric acid.

本文对抗结核药物盐酸乙胺丁醇的合成进行了系统地研究，包括原料-2-氨基丁醇的合成、拆分，-2-氨基丁醇的消旋以及L--酒石酸的回收。

Conclusions］There is a significant difference at protein level between untreated and ethambutol treated mc2155 cells. It suggests that the differential expression analysis of proteomes may be useful for further study on microbiostatic mechanism of ethambutol and search for new targets toward anti-TB drug development.

结论］乙胺丁醇处理前后耻垢分枝杆菌mc2155细胞的蛋白质组具有差异，这种蛋白质组的差异分析有助于进一步研究乙胺丁醇抑制分枝杆菌生长的作用机制并为寻找新的抗结核药物作用靶标奠定基础。

［Objective］To investigate the microbiostatic mechanism of ethambutol, proteomic methods were used to find differential expression proteins in Mycobacterium smegmatis mc2155 cells treated with ethambutol.

［目的］利用蛋白质组学方法，识别乙胺丁醇处理前后耻垢分枝杆菌mc2155细胞后差异表达的蛋白质，为进一步探讨乙胺丁醇抑制分枝杆菌生长的作用机制及寻找新的抗结核药物作用靶标奠定基础。

The L-forms were formed spontaneously or induced by rifampin, isoniazid and ethambutol.

结核分枝杆菌稳定L型可自发形成，也可被利福平、异烟肼和乙胺丁醇诱导形成。

D. N big mouse model was successfully made by adopting single side kidney cutting with induction, then by 24 week continuos observation on the change of various values of kidney and function, through testing of immunity florescence, electro-scope and optical scope, what we can see from model group is that typical kidney small cell got hardened by knot, and discarded, and dead, also small tube withered, small cell of on base film got thick, cell capsule wall was fibred, and base film got double layered.

实验研究采用单侧肾切除加以链脲佐菌素诱导，成功地复制出糖尿病肾病大鼠模型，对其肾脏结构和功能的改变各项指标，连续进行24周动态观察，并进行免疫荧光、电镜、光镜检测，结果表明：糖尿病肾病模型组可见典型的肾小球节段硬化、废弃、坏死，有大量蛋白管型，肾小球管糖元空泡沉积及脂肪滴，肾小管萎缩，肾小球基底膜明显增厚，球囊壁纤维化，基底膜双层化，有一例结核性肉芽组织及钙化等病理变化。

This may have important significance for protection in the early period of infection.

在感染早期可能具有重要的抗结核保护作用。

An example of one is called isoniazid, which currently is used to treat tuberculosis.

其中一个叫异烟肼的例子，就是目前用于治疗结核的药物。

The drug isoniazid is widely used in the treatment of tuberculosis .

异菸肼是广泛用于治疗结核的药物。

Prophylactic and therapeutic use of isoniazid alone or in combination with other anti-tuberculous drugs carries an appreciable risk of hepatotoxicity.

单独使用异烟肼预防药和治疗剂或者结合其他抗结核药物会携带一种可感知的肝中毒风险。

Objective To establish a rapid PCR detective method of the laboratory monkeys.

目的 建立猕猴结核分枝杆菌PCR快速检测方法。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。