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Objective To study the relationship of endangium proliferation and the expression of metalloproteinases and tissue inhibitors of metalloproteinases after angioplasty of iliac artery in rabbits to investigate the probable mechanism of composite Danshen pill in prevention and treatment of restenosisMethods 30 white male rabbits of Japan (the average body weight was 25~30 kg)were randomly divided into 3 groups:normal control group,model group (intima destroyed by balloon and given hypercholesterol diet),CDP group (intima destroyed by balloon and given hypercholesterol diet plus drug CDP 150 mg/d),10 ones each groupResults The results of iliac artery angiogram and the analysis of pathology:there were lumens stenosis,thinner intima,smaller intima area,in CDP group compared with those in model group,and ratio of intima and tunica media thickness and area among each group (P<001)Immunohistochemistry analysis:the MMP2,MMP9,TIMP1,TIMP2 in model group significantly increased than those in control group (P<001)The CDP group had lower MMP2 and MMP9 expression,higher TIMP1 and TIMP2 expression,and increased MMP2/TIMP1,MMP9/TIMP2 than model group (P<001)The thickening of vascular neointima and stenosis degree of vascular lumen were relevant to MMP2 and MMP9 (r=0896,P<001)Conclusions MMP and TIMP play the very important role in the restenosis process of arteryCDP could inhibit the thickness of vascular neointima after balloon injury,the probable mechanism of which may be inhibiting collagen formation,smooth muscle immigration and decreasing hyperplasia of intima by interfering expression of MMPs and TIMPs

目的 研究兔髂动脉成形术后血管内膜增生和基质金属蛋白酶及其抑制物表达之间的关系,探讨复方丹参滴丸预防再狭窄的可能机制。方法健康成年二级雄性日本大耳白兔30只,平均体重25~30 kg。随机分为3组:正常对照组10只,模型组10只(球囊内膜剥脱加高胆固醇饮食),治疗组10只(球囊内膜剥脱加高胆固醇饮食以及复方丹参滴丸150 mg/d)。结果兔髂动脉造影、血管病理图像分析检测结果:①复方丹参滴丸组较模型组血管造影示管腔直径狭窄、内膜厚度减少、内膜面积减少、内膜厚度和中膜厚度比、面积比,各组之间有显著性差异(P<001)。②免疫组化分析:模型组MMP2、MMP9、TIMP1、TIMP2表达均高于对照组(P<001);复方丹参滴丸组MMP2、MMP9的表达低于模型组,而TIMP1、TIMP2的表达高于模型组;TIMP1/MMP2、TIMP2/MMP9明显增加,差异有显著性(P<001)。③内膜的增生以及管腔的狭窄程度与MMP2、MMP9有很好的相关性(r=0896,P<001)。结论 MMP和TIMP在再狭窄形成中起重要作用;复方丹参滴丸能够明显抑制血管损伤后的内膜增生,可能的机制是通过影响金属蛋白酶MMP2、MMP9及其抑制物TIMP1、TIMP2的表达从而抑制胶原的生成、平滑肌的迁移、增生,而减少内膜的增生。

The result show that this design has expectable compensating effect, the action of control parameters is in agreement with the theoretical results.

仿真试验结果表明该设计方法可以达到很好的补偿效果,各项控制参数的作用与理论推导的结果相吻合。

The results show that the particles in the two phosphor samples are overall spherical-shaped with a mean size of ~300 nm, and their main emission peaks under 147 nm VUV excitation are located at 619 nm. In comparison with Y0.95Eu0.05PO4 phosphor, Y095Eu0.05 (P0.2V0.8)O4 phosphor is a more promising candidate for red-emitting PDP phosphor application due to its higher homochromy and its chromaticity coordinates closer to flammulated chromaticity coordinates (0.67, 0.33) regulated by National Television Standard Committee.

结果表明,制得的Y0.95Eu0.05P(下标 1-xVO4(x:0,0.8)荧光粉的粒径约为300nm,在147nm真空紫外激发下,发射光谱的主峰位于619nm;与Y0.95Eu0.05PO4荧光粉相比,Y0.95Eu0.05(P0.2V0.8)O4具有更好的色纯度,它的色度坐标更接近国际电视标准委员会规定的红色色度坐标(0.67, 0.33),是具有很好应用前景的PDP红色荧光粉。

Using three dimensional fluxional function , the rolling force and energy parameters of oval round pass sequences for hot continuous bar rolling were analyzed.

采用三维流函数法对棒材热连轧时的椭圆-圆孔型系统进行了力能参数的解析,其结果与实测结果符合很好。

And the effects of two kinds of bulge processes on the thickness distribution and forming limit were compared.It is concluded that proper application of forward-backward bulge can improve the uniformity of thickness distribution and greatly increase the formin...

结果表明,采用合理的正反胀形可以很好地改善成形件的厚度不均匀性并大大提高成形极限,实验验证了仿真和实验结果相吻合。

It is proved that this method is feasible and effective, and can deal with the condition evaluation problem with uncertainty and incompleted evidences. The evaluation results can be used as a support for maintenance decisions.

结果表明,该方法可行有效,很好地解决了部分证据不精确和不完全的状态评价问题,评价结果为维修决策提供依据。

This paper describes a new algorithm of image enhancement of impulse noise based on PCNN time matrix and rough sets indiscernibility relation. For noisy gray images, the results of computer simulations show that the image noise can be reduced efficiently and the image becomes clear and the target details of the image can be enhanced better by using this algorithm. In addition, the effects of this algorithm are better than usual image enhancement algorithm.

基于粗集理论中的不可分辨关系的等价概念及PCNN赋时矩阵,提出了一种含有脉冲噪声的图像增强算法,计算机仿真结果表明,对被噪声污染的灰度图像,用基于PCNN与粗集理论相结合的图像增强算法处理后,图像噪声得到有效抑制,画面更清晰,图像中目标的细节也得到了很好的增强,其结果优于常规方法。

3When subjected to the seismic ground motion of the shock type, the shallow, thin and narrow liquefied lenticle may amplify the response of the building with short period.

计算结果表明:(1)所采用的方法与已有的模型实验结果有很好的对应关系,可用于分析建筑物存在下的场地砂土液化问题;(2)饱和砂土透镜体液化对短周期建筑物主要起到隔震作用,且随着透镜体厚度、埋深和宽度的增加以及场地输入地震动加速度的增大,减震效果有所增加;(3)在冲击型地震动作用下,埋深浅、宽度和厚度小的液化透镜体有时却对短周期结构加速度反应起到增大作用。

The result proves that not only the grinding wheel's cost is lower, but also the effect is better than ordinary wheel in hardness, strength density and metallograph. The wheel has good abilitg of keeping grinding material and good grinding property. It can satisfy reguest of ELID grinding technology for wheel's selectrolytic and forming film. It is an ideal, practical and special grinding wheel of ELID grinding.

实际应用结果表明,该砂轮成本低、效果好,在硬度、强度、密度、组织等物理性能方面较商品砂轮有较大提高,并具有很好的把持磨料的能力和良好的磨削性能,充分满足ELID磨削技术对砂轮电解生膜的要求,是一种较为理想的实用的ELID磨削专用砂轮。

Result Richards Model and Monodic Quadratic Equation could properly describe grain dry matter growing process and the change process of grain filling rate with days after anthesis. There was big difference in average grain filling rate, maximum grain filling rate under different planting density. Average grain filling rate 1.26 mg/ and maximum grain filling rate 2.44 mg/ of T7 were the quickest, and the average grain filling rate 0.94 mg/ and maximum grain filling rate 1.99 mg/ of T12 were the slowest, and the maximum difference percentage of the average grain filling rate and maximum grain filling rate among different density were 33.98%, 22.61%. There was significant correlation between average grain filling rate, maximum grain filling rate, grain filling active duration, rapid increasing stage and thousand grain weight, and the correlation coefficients were 0.628*, 0.630*, 0.849**, 0.739**. Active grain filling duration contributed mostly to TGW.

结果不同密度处理间千粒重、单位面积穗数、穗粒数、单株穗数、单位面积籽粒产量均存在显著差异;不同密度处理冬小麦的籽粒灌浆均符合慢-快-慢的&S&型生长特性,用Richards模型能很好地模拟冬小麦籽粒增重过程,用一元二次抛物线方程能较好地模拟冬小麦灌浆速率随花后时间变化过程;不同密度处理间平均灌浆速率、最大灌浆速率有较大差异,最大差异率分别为33.98%、22.61%,T7的平均灌浆速率1.26mg/及最大灌浆速率2.44mg/均最大,T12的平均灌浆速率0.94mg/及最大灌浆速率1.99mg/均最小;平均灌浆速率、最大灌浆速率、灌浆活跃期、灌浆快增期与千粒重显著或极显著正相关,相关系数分别为0.628*、0.630*、0.849**、0.739**;通径分析表明,灌浆活跃期对千粒重的贡献最大。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

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