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The quality of interior environment in nursing home residents will become one of the attention-getting subjects due to the gradual increase of aging populations This paper directs at the research of nursing home's interior environment factors in Tainan We use the standard of international practice to analyze the intrinsical data of environmental monitoring and establish the characteristics which from environmental physical reaction of nursing home The research items are air environments (PM10 CO CO2 formaldehyde TVOC) temperate environments and light environment (illumination average brightness daylight factor) etc There are the inductive conclusions of this research: 1 In basic medicine the clinical diagnosis means the theory and technique about physical examination with patients The definition of clinical diagnosis in architecture should be the diagnosis of building preserve and improve the feasible way to extend building's service life and assure the residents of the healthy quality of interior environment The object of clinical diagnosis in architecture is not only to ensure the use of structure and environment quality but also keep the structure and environment quality in sustainable; therefore creating an efficient system of preserving plan is needed 2 It is an accurate and technical circumstance which about improving remedying and reconstructing the problems of structure space This circumstance includes finding questions ensuring causation ascertaining ultimate strength evaluating environment quality estimating the necessary of restoration and implementing on a suitable way Furthermore when reconstructing and ameliorating the appearance of structure space it should be respected and the memories of it should be preserved 3 In clinical diagnosis of environment quality of space the question of physical environment and the deficiencies of structure must be separated The structure space of construction and the high quality of space should be inspected strictly then observed the crucial reason that can find out any invisible and hidden causes The diagnosis of construction is to observe the reason of destroyed structure The environmental diagnosis of indoor and outdoor is to find out the crucial reason that influences health 4 In order to decrease the iterant problems the construction and environment of space should be diagnosed However the destruction by natural strength and artificial using by human are important causes that can affect the service life of construction Searching the cause of disease just like curing the patient which includes inspection diagnosis cure and prevention We tested the thermal conductivity of siding material in this research and then found out the roof east vertical face and west vertical face have most radiant heat especially the construction of RC The characteristics of opaquely outer casing have relations with the thermal conductivity of wall to wiz the ability of heat insulation Therefore increasing the efficiency of heat insulation and decreasing the endoergic factor of insolation are very important to temperate environments

而随著国内老年人人口逐渐增加,逐渐迈向高龄化之同时,对於高龄者使用空间之室内环境品质相关议题之探讨,亦成为未来我们需加以关注之议题之一。主要为针对台南某安养中心室内环境因子进行检测调查工作,利用现场室内环境测定以取得有效的实测数据;再藉由汇整相关国际评估基准,并进行实测数据比对分析,建立老人安养中心对物理环境反应之特性。并以前期相关研究文献回顾与老人安养中心实测案例现场的实验,来了解不同空间物理环境特性之影响,并将结果回馈实际建筑及室内设计之用。调查工作项目包含:空气环境之PM10、CO、CO2、甲醛、TVOC;温热环境之室内温度、相对湿度、人体PMV、PPD;光环境之照度、均齐度、昼光率等因子调查。本研究结果可归纳以下几点结论: 1 所谓临床诊断医学乃相对於基础医学而言,是指实际与病人接触的医疗及护理行为中牵涉到的理论和技术;而建筑的临床诊断的定义应为建筑本体与室内外诊断、维护及改善所有可行的方式来延长建筑物的寿命,并确保人与室内环境空间品质的健康。建筑临床诊断目的为确保结构体与环境品质能继续使用,而能维持所需要的效能及承受能力。一个有效的维护计画体系是必须建立的 2 在建筑空间之问题改善、治疗与修复执行中,是一个精确与技术性的事项,其中包含找出问题、确定原因、评估结构应力强度、评估环境品质、评估修复与改善必要性、选择及执行一个适当的过程。其改善与修复也必须尊重建筑空间原有色彩与形貌,并保留原有记忆及文化。 3 在临床诊断中空间环境品质中,物理性环境问题与结构构件缺陷必须分别判断,诊断建筑空间之结构与空间舒适品质必须详细观察其症结性问题,才能发现任何隐藏及有潜伏性缺陷的原因。建筑本体诊断是观察出建筑本体之破坏原因,而是内外空间环境诊断目的在於的找出影响健康因素之症结性问题。 4 建筑本体与空间环境之预防评估目的为降低与抑制问题的再发生。然而,自然力的破坏与人为使用因素皆是影响建筑生命期之主要因素,找出病源问题就如同医生对病人的处理,包含了侦查、诊断、治疗以及预防。 5 本研究以外墙材料热传导率测试结果发现,屋面与东西向立面是承受辐射热最多的地方,尤以 RC 的建筑更甚,不透明部分的外壳能特性主要与壁体的热传透率即隔热能力有关,但是承受来自日射的吸热影响,因此增加隔热性能与降低日射吸热因子是对温热环境是非常重要的。

The distribution of temperature stress was calculated by finite element analysis. The results showed when the surface temperature of concrete was higher than 110℃, the temperature stress was more than 4 MPa without regard to the creep. This might be lead to the damage of the surface of concrete. At the same time, a lot of microstructure analysiss such as XRD, SEM, IR, HSA etc. were done to analysis the difference of the component and microstructre of concrete before and after corrosion. The results indicated that the decomposion of CSH gel and calcium hydroxide and the creation of dilatability calcium oxide were the internal reason of the deterioration of concrete in the corrosion form of high heat.

该文通过有限元方法计算了由于温度而产生的结构应力分布,计算结果表明当混凝土表面温度超过110℃时,如不考虑徐变时表层混凝土受到的温度应力将超过4MPa,这使得表层混凝土很容易因温度应力而破坏;同时通过X射线衍射分析、扫描电子显微分析和混凝土孔结构分析等多种微观结构测试手段,分析了混凝土受热前后的宏观性能以及微观组成和结构的变化,指出混凝土原水化产物如水化硅酸钙凝胶和氢氧化钙的分解以及膨胀性产物氧化钙的产生是高热腐蚀形式下混凝土破坏的内在原因。

The damage assessment of structures is based on the earthquake damage criteria and damage model. The author in the text, through the existing description of earthquake damage criteria and damage model, believes that the actual earthquake damage can be showed by the dual damage criteria on the basis of deformation and energy.

结构的地震破坏评估是建立在地震破坏准则和破坏模型基础上的,本文在对己有的地震破坏准则和破坏模型进行评述的基础上,认为基于变形和能量的双重破坏准则可较好地反映结构的实际震害,并根据倒塌极限状态方程提出了改进的 Park&Aug。

The internal codes of RC were still constituted by the source of ACI system.at present. This detection could be found when treat the destruct mode of RC. Failure mode of bending behavior have the tractility to be a warning for hold off. Whereas shear would often fracture in a second and make big toll. Accordingly, avoid the shear failure happening which had been an important subject of structural design.

中文摘要目前国内对RC规范的订定仍以ACI 规范系统为主要依据,而探讨RC结构的破坏模式时可以发现,挠曲的破坏行为富有延展性,具有延迟预警的效果,反之剪力的破坏则常发生於顷刻之间,往往造成重大伤亡产生,因此避免剪力破坏的发生在结构设计上仍是项重要的课题。

The shearing failure of structural plane is considered to be corresponding to the maximum of real contact area, a criterion is given to distinguish the shearing failure of structural plane and a new select method of shear strength is brought forward subsequently; Examine the influence of geometrical features and thickness of weak intercalation on the integrative strength of weak structural plane based on the composing of basic strengths, formative mechanism of shearing plane and failure pattern; and present the quantitative relation between the strength and thickness.

4详细研究了依附型滑动面中的硬性结构面和软弱结构面力学特性和破坏模式,对硬性结构面引入摩擦学中的粘着摩擦理论,着重研究结构面在剪切过程中实际接触面的变化规律,提出实际接触面积的最大点即为强度破坏点,并结合实际数据进行了验证;对软弱结构面则从其基本强度的组成、内部剪切面的形成机理和破坏模式入手,研究了结构面的几何特性、夹层厚度和强度关系对软弱结构面综合强度值的影响,并给出了定量关系式。

The thesis toke problem of deformation and destroying of the earth mass as it's invention, integrated the earth mass's existing environment, ingredients and macrostructure, discovered mechanism of deforming and destroying, made clear the relationships between those.Through outdoors samples, indoors examination surface wave testing and audio wave testing ,do some research on physical, mechanical, chemical, disintegrative and dynamics property of stuff of earth mass and proposed four kinds of earth mass's stuff formed type;under the guidance of theory of dominant structural surface and adopting precision measurement of structural surface, proposed three dominant kinds of structural surface assembling;based on those , proposed four types of earth mass's deformation and destroying, carried out rationed estimation of stability on four types, then definite the characters of deforming and destroying and controlled relation between environment , stuff, macrostructure and deformation and destroying of mass earth, and breakthrough ordinary principle about soil's deformation and destroying, further proofed the theory of earth mass cybernetics's popularization

本学位论文针对台地危险土体的变形破坏问题,将土体的赋存环境、土体物质组成和土体宏观结构的研究紧密地结合,阐明了土体变形破坏的机制,明晰了土体变形破坏与土体的赋存环境、土体材料组成、土体宏观结构三要素之间的关系,并从土体的物质组成的角度,以野外取样、室内实验、现场面波、声波无损伤测试为手段,研究了土体物质的物理、力学、化学、矿物、崩解性、动力学性质,提出了研究区内土体物质成分的四种组合形式;以优势结构面理论为指导,以结构面的精确测绘为手段,通过统计、归纳与分析,提出三种有利于台地危险土体变形破坏的优势组合形式;据此提出了具有广泛代表意义的台地危险土体变形破坏的四种模式,并对其进行稳定性评价,从而明确了危险土体的宏观结构对变形破坏的控制作用,映证了土体结构控制论。

Parameter study of three-way guyed mast structure ;2. Damage detection method for vertical bars of mast structure in time domain;3. According to structural dynamic features of mast structure and the change of dynamic properties after damage modal analysis is applied for damage detection.

研究了桅杆结构的破坏原因和破坏机理,针对桅杆结构本身的结构动力特性和损伤后的动力特性改变,对应用模态分析方法在桅杆结构的损伤诊断的应用问题进行了分析,指出了模态分析的损伤诊断方法在桅杆结构中的应用方向。

The failure mode of honeycomb fibreboard was analyzed from the structure of honeycomb fibreboard and mechanical aspects.

从蜂窝纸板的结构和力学角度分析了蜂窝纸板的破坏模式、纸蜂窝芯的压缩破坏过程和蜂窝胞壁壁板受载破坏机理,得知蜂窝纸板的压缩破坏主要与纸蜂窝芯的结构和蜂窝胞壁的屈曲有关,为蜂窝纸板缓冲性能的研究提供了理论基础。

At a certain range, habitat loss and its spatial structure can benefit the control of the epidemic disease, which indicates the possibility of using human disturbance in habitat as a potential epidemic-control method in conservation.(6) Not only the quantity of habitat loss but also the spatial correlations of patch types caused by nonrandom habitat loss affect the invasion and transmission of disease. More fragmented landscape (high amount of habitat loss, low clustering of lost patches) hinders the parasitic infection, which also indicates that whether the spatial heterogeneity benefits or hinders the invasion is dependent on the considered ecological process.(7) Two components of the spatial heterogeneity (the amount and spatial autocorrelation of the lost habitat) form a trade-off in determining the host-parasite dynamics.(8) Within a certain range of habitat loss, host can counterbalance the positive and negative effects, and shows a rising tendency.(9) The epidemic is more likely to break out in the prey-predator system if only a small amount of habitat loss.(10) A highly aggregated distribution of species is a common behavioral strategy when dealing with habitat loss or other environmental stresses.(11) The parasite-host/prey-predator eco-epidemiological systems have the similar mechanism with the intraguild predation systems, and the predator acts as the intraguild predation, the infected prey acts as intraguild prey, and the susceptible prey acts as shared resource.(12) Species at the highest trophic level are no longer affected the most by habitat loss, which depend not only on the biological mechanism but also on the external environmental disturbances.

随着邻体数目的增加,病毒的感染力度变得更大而且在空间上形成聚集的波形;(5)生境破坏及其空间结构在一定范围内有利于疾病的控制,这暗示人为对生境的干扰可作为疾病控制的一个潜在方法;(6)生境破坏的数量以及不同类型生境的空间分布格局都显著地影响了寄生病毒的入侵和传播,生境破碎化程度越高(高丧失斑块的数量或低聚集程度),将越有害于病毒的入侵和传播,这暗示了空间异质性是否有益于物种的入侵依赖于所考虑的生态过程;(7)由生境破坏引起的空间异质性的两个组分之间存在负偶联关系trade-off(8在适度的生境破坏范围内,宿主种群能够平衡生境破坏带来的正负两种效应并呈现增长趋势;(9)在捕食-食饵系统中,寄生感染病毒极有可能在生境破坏量较低时爆发;(10)物种在面临生境破坏或者其它环境压力时表现出更高的聚集分布策略;(11)寄生-宿主/食饵-捕食生态传染病系统与共位捕食食物网结构具有相似的生物机制,其中捕食者扮演共位捕食者的角色,已感染食饵作为共位食饵,易感染食饵扮作共同消耗的资源;(12)位于最高营养级水平的种群对生境破坏的响应不一定是最敏感的,这不仅依赖于内在的生物机制同时也依赖于外在的环境干扰。

Ethambutol is a first-line drug used for antituberculosis therapy. It is often used in combination with isoniazid, rifampin, pyrazinamide, and streptomycin. The action of EMB in antituberculosis mechanism is the destruction of cell wall of tubercle bacilli via binding the target molecule -- arabinosyl transferases. These enzymes are involved in the polymerization of the cell wall arabinan. Inhibition of arabinan synthesis by EMB results in the accumulation of mycolic acids, leading to cell death.The EMB-resistance of MTB is involved with the mutation of emb operon or the over expression of emb operon.

乙胺丁醇是和异烟肼、利福平、链霉素、吡嗪酰胺联合治疗结核病的一线抗结核药物,EMB对结核分枝杆菌的作用机制与分枝杆菌胞壁结构破坏有关,主要作用于靶分子阿拉伯糖基转移酶,抑制了阿拉伯糖基聚合入阿拉伯半乳聚糖,从而影响细胞壁分枝菌酸-阿拉伯半乳聚糖-肽聚糖复合物的形成,导致菌细胞的死亡。

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