结构破坏

Through model test of new high- strength steel conical shell with ring frame ,and relevant analysis,it is shown in this paper that the failure of ring-framed conical shell can be traced to the neutral plane on longitudinal section where the structure strength is relatively weak.

通过新的高强度钢材环肋圆锥壳模型实验，及采用解析方法分析表明，环肋圆锥壳体破坏的原因是结构相对薄弱处纵剖面上的中面应力所致。并提出用"灰色系统"理论预测破坏载荷的计算方法，建议今后模型实验和现役潜艇的耐压船体寿命估算中可采用这种方

Based on the research production, with three prestressed concrete hollow slabs from the bridge in active service for ten years, this essay studies the ultimate bearing power ,the load-bearing failure mechanism and structure reenforcement measures influence on them, through examination of each performance index, failing load test, theoretical analysis and computing research work.

对预应力混凝土桥梁结构在使用中存在的问题及国内外相关研究发展水平进行了综述，指出目前对旧桥预应力混凝土空心板实际极限承载能力进行相关研究的必要性及其重大意义； 2、对旧桥预应力混凝土空心板的混凝土强度、碳化深度、预应力筋的锈蚀状况以及裂缝状况的检测评定； 3、通过破坏荷载试验，对损伤旧桥预应力混凝土空心板的受力性能进行试验评定； 4、采用在桥面做混凝土叠合层的加固措施，通过破坏荷载试验对加固后的旧桥预应力混凝土空心板的受力性能进行评定； 5、提出在役旧桥预应力混凝土空心板的维护、加固和使用建议。

Erosive scutum, soft tissue mass filling the enlarged and clear margin bony cavity and structural bone destruction were the basic CT features of cholesteatomatous chronic otitis media.

盾板破坏，有软组织充填的边缘清晰的扩大骨腔隙，中耳腔结构骨组织的破坏，是胆脂瘤CT表现的基本特征。

The hyperbolic-type nonlinear model and rigid and perfectly-plastic model are usually adopted to simulate the constitutive behavior in tangent direction of contact surface. in fact, however, the hyperbolic-type nonlinear model can not definitely display the plastic flow deformation after shear failure while rigid-perfectly-plastic model can not describe the nonlinear deformation before shear failure.

对于土与结构间接触面的切向本构关系，目前通常采用双曲线非线性弹性模型或刚塑性模型来描述，但是，传统的双曲线非线性模型不能明确地表达剪切破坏后的塑性流动变形特性；而刚塑性模型又无法描述剪切破坏之前的非线性弹性变形。

Results: There were 56 cases of recurrent laryngeal carcinoma having CT findings invaded by multiple laryngeal and neck structcres, palapharyngeal irregular intensified mass that have normal ovenlying mucosa of laryngeal cavity in 23 cases (40%), and are not detectable on endoscopy; ealaged cervical lymph nodes 16 cases (28.6%); thyroid cartilage/cricoid cartilage destraction 3 cases (5.3%); internal carotid artery and internal jugular vein involvement 5 cases (8.9%); cervical vertebral 2 cases (3.6%) and carcinoma of the orifice of tracheotomy in 5 cases (8.9%).

结果：本组56例复发性喉癌以术后多种喉部和颈部组织结构受侵为主要CT表现特征。喉旁不规则强化肿块23例，占40%；颈淋巴结肿大16例，占28.6%；喉软骨破坏3例，占5.3%；颈动脉工鞘受累5例，占8.9%；颈椎骨质破坏2例，占3.6%；气管造漏口癌5例，占8.9%。

In fact, on one hand, it is often found that two graphs with the same number of verticesand the same connectivity(edge-connectivity) may result in entirely different forms after a minimum disconnecting set of vertices is removed, one may be totally disconnected while the other may consist of a few very stable components, and thus be much easier to reconstruct.On the other hand, we often face this question: how easily can we disrupt a system at the least cost, on the contrary, when we set up a system, especially a communication system, we try our best to make it as stable as possible that it can be reconstructed easily if it do get disrupted .

对于两个具有相同点数，具有相同点连通度的图，从图中分别去掉使图不连通的点集后，所得图的结构可能完全不同，这是因为点连通度、边连通度和局部点、边连通度等连通性参数仅反映了系统被破坏的难易程度，而对系统遭受破坏的程度并没有明确的反映。

First, the great data of the earthquake disaster for the tunnel and underground structure in home and abroad are analyzed.

首先，对国内外有关隧道及地下结构的震害资料进行分类、整理和研究，总结出山岭隧道的震害破坏模式、震害影响因素及震害破坏机理。

RESULT: 1.Ouabain act on lens sodium-pump,under the LM,lens anterior capsular membrane discontinuous,epithelium cells clustered,occluding zonule seperated,lens fiber layers fractured.Under the EM,cells totally hollowed,mitochondria swelling,myelin figure appeared.RT-PCR examine the expression condition of αsubunit of sodium pump on mRNA level,α1、α2 and α3-isoform are all decreased.2.Digoxin act on lens sodium-pump,under the LM,lens cell oedema,linkage distructed,extensive exfoliation.Under the EM,plasma appeared little half-transparant hollow region,mitochondria swelling and ridge disappeared. RT-PCR examine,α1、α2 and α3-isoform are all decreased.3.Amphotericin B act on lens sodium-pump,under the LM,lens epithelium cells linked tightly,arranged in-line,lens fiber layers arranged tightly and regularily.Under the EM,abbundant cellular organes,exuberant cells function indicated. RT-PCR examine the expression condition of αsubunit of sodium pump on mRNA level,α1 and α3-isoform are increased significantly,demonstrated isoform-specific action.4D-thyroxine act on lens sodium-pump,under the LM,lens plasmalemma integrated,cells arranged tightly and regularily.Under the EM,nucleus fission appeared,desmosome half-desmosome and tensile microfilaments linked the cells. RT-PCR examine,α2 and α3-isoform are increased, also demonstrated isoform-specific action.5.Vitamin E act on lens sodium-pump,under the LM,lens anterior capsular membrane continuous and smooth,epithelium cells tightly linked,lens fiber layers appearede hollow region occasionally.Under the EM,lateral membrane high density belt appeared,abundant nucleolus. RT-PCR examine,onlyα1-isoform are increased, demonstrated significantly isoform-specific action.6.DMSO act on lens sodium-pump,under the LM,lens anterior capsular membrane slightly thicker,cells linkage partly distructed.Under the EM,plasmalemma denaturation,mitochondria swelling.RT-PCR examine,α1、α2 and α3-isoform are all altered slightly and haven't significant meanning.

结果：1、哇巴因作用于晶状体钠泵后，光镜下晶状体前囊膜断裂、上皮细胞聚积、闭合连接分离、纤维板层裂隙，电镜下全层细胞空泡化、线粒体肿胀出现髓样结构，RT-PCR法检测晶状体钠泵α亚单位α1、α2及α3三种重整异构体在mRNA水平的表达均减弱。2、地高辛作用于晶状体钠泵后，光镜下晶状体细胞水肿、细胞连接破坏、广泛剥离，电镜下胞质见少许半透明空化区、线粒体肿胀嵴消失，RT-PCR法检测晶状体钠泵α亚单位α1、α2及α3三种重整异构体在mRNA水平的表达均减弱。3、两性霉素B作用于晶状体钠泵后，光镜下晶状体上皮细胞紧密连接、线状排列、纤维板层紧密规整，电镜下细胞器丰富、细胞功能旺盛，RT-PCR法检测α1及α3表达显著增强、具有一定的重整异构作用特异性。4、D甲状腺素作用于晶状体钠泵后，光镜下晶状体质膜完整、细胞排列紧密规整，电镜下胞核见分裂像、细胞间有桥粒、半桥粒及张力微丝，RT-PCR法检测α2及α3表达均增强、亦有一定的重整异构作用特异性。5、维生素E作用于晶状体钠泵后，光镜下晶状体前囊膜连续光滑、上皮细胞紧密连接、纤维板层偶见空化，电镜下囊侧膜内有高电子密度带、细胞核仁丰富，RT-PCR法检测仅有α1的表达显著增强、具有极强的重整异构作用特异性。6、二甲基亚砜作用于晶状体钠泵后，光镜下晶状体前囊膜轻度增厚、细胞连接部分破坏，电镜下质膜变性、线粒体肿胀，RT-PCR法检测晶状体钠泵α亚单位α1、α2及α3三种重整异构体在mRNA水平的表达无显著改变。

The presterssed anchor cable frame combined with backwall, drainage is necessary due to longtime sability and permanent utilization.Firstly,according the study of engineering of geology situation of the high slope, the mechanism of deformation failure and the major hazard of the high slope of PanMei is analysed comprehensively.And the whole slope is divided into two different geology enginnering areas:Western slope(1160 section plane -1240 section plane)and Eastern slope(1240 section plane -1320 section plane). The result of 3D numerical simulation is the same as geology judgement. Later,slope cut (1:0.75) is implemented based on the engineering comparison and criterion.Meanwhile, Limit equilibrium method , Monte Carlo Probabilistic slope stability the stability , Sensitivity analysis and Finent element method of for assessing the cutted slope stability is carried out. The result indicates that Western slope is instable, Eastern slope is relatively stable.So much attention should be paid to Western slope.Different reinforcement measures in different areas are given according to its stability and meet economical request. Gravity wall is introduced in accordance with landform in order to prevent small falling at the foot of the high slope ,which will be a threat to the high slope stability. Handling measure is also applied to Eastern slope. At last,FLAC3D numerical analysis shows the feasibility and reasonableness of the handling measure of the high slope.

论文首先研究了边坡的工程地质条件，全面分析边坡的变形破坏机制和边坡的主要地质灾害，将边坡分为西段不稳定边坡区(1160剖面～1240剖面)和东段相对稳定边坡区(1240剖面～1320剖面)，通过三维数值模拟再现了边坡在自重作用下的破坏机制和过程；在此基础上通过工程类比和规范要求，确定按照1：0.75进行放坡处理，并分析了放坡后边坡的稳定性状况，分别通过极限平衡法、蒙特卡洛法概率分析、参数敏感性分析和有限元稳定性计算等多种方法对边坡在各种工况下的进行稳定性研究，计算结果表明，西段边坡较之东段边坡稳定情况差，是边坡支护的关键之处，而东段边坡相对是稳定的；边坡的综合治理措施选用的是框架锚索并结合挡土墙和排水工程，治理设计根据不同区段的稳定性情况采用不同的支护结构，做到了经济合理的要求；在边坡的坡脚设置重力式挡土墙，防治边坡小规模的崩塌，会对上部的锚索支护护造成不利影响，进而影响边坡的稳定；东段边坡的填方区也给出了治理对策；最后通过三维显示拉各朗日有限差分程序(FLAC3D)模拟了高边坡放坡和支护效果，论证了治理措施的有效性和合理性。

The staining of F-actin in the ischemia reperfusion group was decreased significantly （P.05） compared with the normal control group. There was a marked loss of canalicular microvilli and distension of canalicular lumen in the ischemia reperfusion group. The staining of F-actin in the LA group was significantly increased than those in the I/R group （P.05）. Conclusions: Ischemia reperfusion induces an disruption of bile canalicular F-actin microfilaments and a loss of microvilli. Alpha-lipoic acid can protect bile canalicular F-actin microfilaments against IRI.

肝脏I/R可造成胆小管F-actin微丝破坏、微绒毛丧失，导致胆小管收缩减弱，胆汁排泄功能受损，这可能是大鼠肝脏I/ R后缺血型胆道病变发生的主要机制；α-硫辛酸通过清除氧自由基，降低脂质过氧化反应，调节细胞内氧化剂-抗氧化剂的含量，保护胆小管F-actin微丝结构免遭缺血再灌注损伤破坏，进而预防和治疗缺血型胆道病变。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！