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Each of these bundles is called a nucleosome, and many nucleosomes are bound together by the continuing strand of DNA, which forms a string of beads that further coils to form one of two kinds of chromatin, either euchromatin or heterochromatin.

所有细胞核的最显著的特点就是染色体,由DNA和组蛋白所组成的染色质构成,DNA绕行在由4个相似的组蛋白分子结合而形成的柱状的芯上,这一结构称为核小体,核小体之间由连续的DNA链连接,形成串珠样结构,进一步盘曲形成常染色质或异染色质。

On the basis of gathering data from previous study and researching the stabilization and reinforcing technique of the typical high slope in west approach road, through in-situ tracking investigation and monitoring to the west road, and by way of studying the interaction between slope body and anchoring structure, monitoring data, the result of grey prediction and fuzzy comprehensive assessment, and adopting the idea of integrating prototype investigation and indoor experiment analysis, mechanism analysis and simulation research method, safety factor analysis and interacting relationship study, in-situ monitoring and safety evaluation, and using the theories of engineering geology, geotechnique, rock body mechanic, finite element method and fuzzy mathematics, this paper studies the long-term safety of the typical high slope specially.

本文在收集前人研究资料的基础上,采用原型调研与室内分析相结合、机制分析与模拟研究相结合、安全系数分析与相互作用关系研究相结合、现场监测与安全性评价相结合的思想,通过对鹧鸪山隧道西引道典型高边坡的现场跟踪调研与监测,运用工程地质、岩土工程、岩体力学、有限元理论、灰色系统理论、模糊数学等先进理论和方法,在对西引道典型高边坡的稳定性、整治与加固技术研究的基础上,通过边坡地质体与锚固结构相互作用分析、边坡监测数据分析、边坡变形灰预测分析以及模糊综合评判等途径,重点对治理后的典型高边坡的长期工程安全性进行了系统深入的研究。

NON-DRYING CLEANSING LOTION removes all makeup and impurities from sensitive skin WASH-OFF CLEANSING LOTION dissolves dirt and oil, leaving skin clean and refreshed MAKEUP REMOVER gently removes all traces of makeup without irritation especially around eyes NEUTRAL CLEANSING BAR a gentle long lasting glycerin based soap with humectants to hold moisture and protect skin BALANCING CLEANSER prepares your skin with thorough cleansing and gentle exfoliation AHA REVITALIZING CLEANSER 4 a 4% glycolic acid based formulation for all skin types which gently cleanses and revitalizes skin DAILY MOISTURE SPF 15 combines hydration with Vitamins A, C and E for enhanced antioxidant protection - protects against both UVA and UVB radiation FACIAL MOISTURIZING CREAM binds moisture to the skin, excellent for dry and mature skin LIGHT TEXTURED MOISTURIZER a lightweight hydrating treatment OIL-FREE ULTRA LIGHT HYDRATOR a sheer lightweight lotion that provides hydration without oil - perfect for oily and acne prone skin HYDRATING SERUM delivers a powerful dose of hyaluronic acid to help restore aging skin to its ideal state SUPER RICH EYE CREAM combines Vitamins A, C and E with intense moisture binding ingredients ULTRA GENTLE EYE CREAM a lightweight and fragrance-free cream that helps to minimize fine lines and puffiness around eyes AHA REVITALIZING EYE CREAM moisturizes and helps to eliminate the signs of aging

你好 翻译如下非干燥洁净乳液消除所有的化妆及杂质从敏感的皮肤讲小康洁净乳液溶解灰尘和油,使皮肤清洁和刷新化妆剂轻轻地消除所有的痕迹化妆特别是在不刺激眼睛中性洁净英美柔和持久甘油肥皂基于举行水分和保护皮肤平衡洁面乳准备您的皮肤彻底清洗和温和去角质美国心脏学会振兴洁面乳 4 %乙醇酸基础制定的所有的皮肤类型轻轻清洁皮肤每日水分的SPF 15 结合水与维生素A, C和E ,加强抗氧化保护-防止两种紫外线和UVB辐射面部润肤乳结合水分的皮肤,非常适合干燥和成熟的皮肤光织润肤品一个轻量级水化治疗无油超轻型纯粹轻量级水化洗剂,提供无油-适合油性和青春痘的皮肤容易保湿血清提供了一个强大的剂量透明质酸帮助恢复皮肤衰老的理想状态超富眼霜结合维他命A, C和E与激烈的水分结合成分超温和的眼霜一个轻量级和香料无霜,帮助减少细纹与虚胖周围的眼睛美国心脏学会振兴眼霜润泽,并有助于消除老化的迹象

In terms of method, the thesis makes an analysis, a synthesis and a generalization of the modern Chinese and Japanese moral education idea with the combination of historical research and comparative research, macro analysis and microanalysis, general research and specific investigation, integral relation and individual development, revealing the similarities and differences between the modern Chinese and Japanese moral education ideas and the inherent law governing their formation.

在研究方法上,采取了历史研究与比较研究结合,宏观把握与微观梳理结合,一般研究与个案考察结合,整体关联与单项发展结合等交叉并用的研究方法,对中日近代道德教育理念进行分析、综合与概括,揭示了中日近代道德教育同质与异质特征,及道德教育理念形成演进的内在规律。

Membrane affinity quantified by IAM and liposome/buffer systems was a more efficient predicator of α values than hydrophobicity from n-octanol/buffer system. Consequently, not only hydrophobic force but also attractive polar extra-interactions involved in the binding to IAM and liposomal membranes but not in an n-octanol phase, ascribed to the binding process within AM. The binding to ordered lipid membrane in the larger part determined drugs'binding to AM intracellular compositions, and the ordered phospholipid plasma membrane was a potential site for drugs'binding in AM.

脂质体/水系统和磷脂膜色谱所测定的膜亲和性比正辛醇/水系统的疏水性更好的预测巨噬细胞内药物的α值,因此包含在磷脂膜色谱中但并不体现在正辛醇/水系统中药物与磷脂膜之间的额外吸引性极性作用力对药物在细胞内结合有着重要贡献;药物与有序磷脂膜的结合在很大程度上决定着药物与巨噬细胞内成分的结合,有序磷脂分子膜可能是巨噬细胞内部潜在的结合部位。

Cluster of differentiation 44(CD44) is a principal cell surface receptor for hyaluronate, a major component of extracellular matrices.

人类白细胞分化抗原作为一种粘附分子,主要与细胞外透明质酸结合,参与关节软骨基质中透明质酸的代谢,因而它与各种骨关节疾病包括大骨节病关系密切。

AVI may be protein matrix and it possesses neither a membrane boundary nor an internal structure,its formation is the result of the anthocyanins transported into the vacuole bind with a protein matrix. In vacuole, AVI is irregular and jelly-like in shape. In AVIs, the attachment of anthocyanins to the matrix protein is likely to be via H-bonds to a sterically restricted site. AVI is suggested to act as vacuolar anthocyanin "trap", preferentially for anthocyanidin 3, 5-diglycosides or acylted anthocyanins. The emergence of AVI can enhance color intensity and results in the "blueness" of color in the vacuole.

花色苷液泡包涵体可能具备蛋白质基质,既无膜包裹又无内部结构,其形成是转运进液泡的花色苷与蛋白质基质结合的结果;液泡里的花色苷液泡包涵体形状不规则,象果冻;在花色苷液泡包涵体中,花色苷可能通过氢键连接于蛋白质基质的一个有限空间位点;花色苷液泡包涵体被认为是液泡中花色苷的&陷阱&,优先摄取花色素3,5-二糖苷或酰化的花色苷;花色苷液泡包涵体的存在可增加液泡色彩的强度并导致&蓝化&。

AMF strains Glomus mosseae-1 and G.mosseae-2 had higher AMF infection rate than other AMF strains, and G.mosseae-2 had the highest Arbuscule percentage in root samples, so G.mosseae-2 can be used as suitable inoculums in tomato organic soil cultivation. Tomato, AMF, Substrate, Seedling stage, Mineral nutrition uptake

为此本试验比较了几种不同丛枝菌根菌种接种剂对基质栽培番茄生长发育和矿质营养吸收的影响,结合对根部菌根侵染率的观察,以筛选适合番茄基质栽培的适宜丛枝菌根菌种。1材料与方法试验于2004年在布达佩斯匈牙利科学院土

The study showed the recombinant wt/mCREG protein depressed the VSMC proliferation depending on dose and the optimal concentration was 400nM;2biologic function of CREG protein and the membrance receptor mechanism:①effect on VSMC migration: the wound healing experiment showed the OB2 cells migration was slower significantly after added wt/mCREG(400Nm) in supernatant. The HITASY cells migration were very slowly and no remarkable change. The gelatinase digestion and Western blot analysis showed the matrix metalloproteinase was decreased and TIMPs was increased;②effect on differentiation: after added wt/mCREG(400nM), the expression of myocardin, SMα-actin, MHC and caldesmin were increased and that of LM-1 and FN were decreased in OB2 cells. These effects were more significant when adding wtCREG.;③effect on VSMC proliferation: Cell cycle assay and BrDU stain showed: after added the wtCREG and mCREG protein, the ratio of cell in G0/G1 phase increased to 0.5773 and 0.5572 from 0.5308 respectively in OB2 group, which increased to 0.7369 and 0.7034 respectively from 0.6297 in HITASY group;3Role of M6P/IGF2R in CREG biologic function:①ELISA and co-immunoprecipitation showed the wt/mCREG binding to M6P/IGF2R directly.②antibody blocking test: when the anti-IGF2R was added to medium at the same time with wt/mCREG at different concentration(2μg/mL、4μg/mL、8μg/mL),the effects of CREG protein which depressing proliferation, migration, secretion and promoting differentiation were blocked, which had the positive correlation to the concentration of added anti body. The studies showed two combinant CREG promoted VSMC switch to differentiation phaenotype, at the same time, depress VSMC proliferation, migration and secreting extracellular matrix.

上述实验结果证实:两种重组CREG蛋白对VSMC增殖均有剂量依赖性的抑制作用,并且相同浓度的糖基化的CREG蛋白对细胞增殖的抑制效应更为显著,最佳效应浓度为400nM;2两种重组CREG蛋白添加后对HITASY和OB2细胞生物学行为的影响:①CREG蛋白对VSMC迁移的影响:刮伤实验发现,加入最佳效应浓度的wtCREG和mCREG蛋白24h后,OB2组迁移能力下降,HITASY组无明显变化;细胞外基质金属蛋白酶-2,9(Matrix metallo-proteinase 2,9,MMP2 ,9)明胶酶电泳检测和Western blot检测结果证实,两种CREG蛋白均可以使OB2细胞合成细胞外基质MMP2,9减少,而组织金属蛋白酶抑制物(Tissue Inhibitors of Metalloproteinases,TIMPs)增加;②CREG蛋白对VSMC分化的影响:加入400nM的wtCREG和mCREG蛋白12h后,OB2细胞myocardin、SMα-actin、MHC、caldesmin表达增加,LM-1、FN表达减少;③流式细胞仪分析细胞周期和BrDU染色分析证实,加入400nM的wtCREG和mCREG蛋白后,OB2组G0/G1期细胞由0.5308分别增加至0.5773和0.5572,HITASY组G0/G1期细胞由0.6297分别增加至0.7369和0.7034;3M6P/IGF2R在重组CREG蛋白的生物学功能中的调控作用:①免疫共沉淀和免疫荧光双染色分析结果显示,CREG蛋白与M6P/IGF2R存在直接结合;②应用抗体阻断实验:将不同浓度的anti- M6P/IGF2R(2、4、8μg /mL)与两种CREG蛋白同时加入培养液中,CREG蛋白抑制VSMC增值、迁移和合成细胞外基质、促进分化的效应减弱,而且与加入anti- M6P/IGF2R浓度正相关。

The five prosthetic groups (FAD, [2Fe-2S], [4Fe-4S], [3Fe-4S] and heme group) required for electron transfer from succinate to ubiquinone were unambiguously assigned into the electron density map. Besides, we find there are some electron densities around the Qp pocket at the matrix side and we believe it represents the head structure of ubiquinone, which is proved by the inhibitor bound structure that 2-TTFA just locating at the Qp site. At the same time, we find there is the second 2-TTFA binding site, locating the inter-membrane side. This finding will change our knowledge about the electron transfer inside Complex II and the ubiquinone transfer between Complex II and Complex III, and endow a new role of Complex II in electron transfer chain.

除了对各个电子传递体( FAD ,[2Fe-2S],[4Fe-4S],[3Fe-4S]以及血红素分子)进行精确定位外,我们在该结构跨膜区靠近线粒体基质一端的口袋 Qp 中,发现了一些电子密度,认为是所结合的辅酶 Q 的头部结构,这一点被与抑制剂结合的复合体的结构所证明,在该结构中, 2- TTFA 恰好结合在口袋 Qp 中,同时,我们还发现了第二个2- TTFA 的结合位点,位于跨膜区靠近线粒体膜间隙一端的口袋 Qd 中,这个发现具有全新的意义,将影响人们对电子在复合物 II 中传递以及辅酶 Q 在复合物 II 与 III 之间转移的认识,促使人们重新复合物 II 在线粒体呼吸链中的角色。

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Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时,他斥责什叶派民兵领导人对中央集权的挑衅行为。

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