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BMI-1(B-cell-specific Moloney murine leukemia virus integration site 1), a Polycomb group repressor, is always present as a PcG complex combined with RING1, HPC2, Mph2, et al. BMI-1 prolongs cells'capacity to proliferate and represses their senescence by repressing the transcription of CDKN2A through acetylhydrolasing or deacetylhydrolasing the Polycomb response elements in chromosome.

BMI-1 (B-cell-specific Moloney murine leukemia virus integration site 1)属于PcG家族,它与该家族其他成员如RING1,HPC2,Mph2等结合形成蛋白复合体,作用于染色质PREs位点,通过对组蛋白进行乙酰化和去乙酰化修饰,从而稳定抑制CDKN2A转录,最终促进细胞的增殖并抑制细胞凋亡。

The researchers combined proteomics, the latest in mass spectrometry technology and the best analytical methods from the field of bioinformatics (the use of computers and statistics to analyze and find patterns in scads of data).

研究者将蛋白组学,最新的质谱测定技术及最好的生物信息学分析方法(应用电脑及统计学分析并检验大量数据类型)相结合。

Through this domain,sterols cause Scap and HMG-CoA Ruductase to bind to Insigs,newly characterized membrane proteins of the ER.

通过这个结构域,固醇促进Scap和HMG-CoA还原酶与Insigs的结合,一种新发现确定其结构的内质网膜蛋白。

Based on thermodynamics and thermo-acoustics, the effect of the pulse tube structure was analyzed. It was found that the cross sectional area of the pulse tube influence greatly the working fluid pressure and temperature distributions.

结合热力学和热声学两方面的理论,对脉管制冷机中脉管的结构进行了分析,发现脉管的截面积与其内工质压力、温度分布匹配与否,对脉管制冷机的性能有很大影响。

All the samples were rescanned once for the Mahalanobis distance methods, and totally twenty eight spectra were separated into three sets for cross-valldation, The two methods can both distinguish the counterfeits of donkeyhide glue successfully.

两种模式识别方法均能准确无误的鉴别阿胶真伪,表明近红外光谱和模式识别技术结合可快速、准确、客观地进行阿胶质镀鉴别,可推广到其他中成药的质量鉴别。

Calculation of loss and gain of components in parentage and altered rocks during metasomatism, reveals that, in rubification and afforestation belts, the components brought in were K〓, CO〓, H〓O, and the components brought out were SiO〓, Ca〓 and Na〓, implying that the early ore-bearing hydrothermal fluids were rich in CO〓 and H〓O. SiO〓 brought out from potassic and chlorite alteration zones could serve as the main source for SiO〓 necessary in the formation of quartz veins, of silicification and of bericitization at shallow depth.

说明早期成矿流体为富含CO〓、H〓O等的碱性流体,其中钾化、绿化带中带出的SiO〓等是浅部石英脉、硅化、绢英岩化中硅质的主要来源,带出的Ca〓与成矿流体中的CO〓结合形成碳酸盐化,带出的Na〓则在浅部形成钠长石脉。

With the combination of engineering examples, influence on the reliability of silty soil slope by rain infiltrate is discussed.

并结合工程实际,探讨降雨渗透影响下对粉质土边坡可靠度的影响。

METHODS The coimmunoprecipitation, sodium dodecyl sulfate polyacry amide gel electrophoresis, peptide mass fingerprint and Western blot analysis were used to isolate and identify the interacting proteins of DNA-PKcs.

通过免疫共沉淀获得DNA-PKcs的相互结合蛋白复合物,SDS-PAGE电泳分离蛋白,肽质指纹分析和Western印迹鉴定蛋白。

Technique development, basic facilities improvement and cost decline make "globalization" communication possible. 4. Globalization of communication technique aggravates the "unfairness" of international communication and leads to its different layers, classes and unbalanced distribution. 5. The end of "cold war" deconstructs the opposite between the East and the West, but not ends the difference between the South and the North and the "civilization conflict". 6. The population redistribution makes the traditional nations and countries in the relevant areas unstable and influences the original national cultural identity. 7."Globalization" communication deepens the alertness of national elite intellectuals, which makes them strengthen their sense of mission to keep and guard the spiritual home of national traditional culture (including traditional belief, value, cultural pattern and so on) that will be possibly subverted and maliciously remade. 8. The combination of "direction" and "strategy", or the speciousness makes big trans-national media corporations sweep away all obstacles and occupy the markets in the developing countries, in which have appeared the phenomenon of "narrations of traditional cultures tending to similarities". 9."Global village": myth or reality? 10. The difference of culture and ideology often causes the different understanding and value judgement to the contents of trans-national communication.

第一部分将中国国家电视文化安全问题放到"全球化"的大背景中加以考量,分别从以下18个维度展开论述:1、全球化语境与我们的抉择;2、与"全球化"同样历史悠久的"国际传播";3、技术的进步和相关基础设施的广泛建立并不断完善以及使用成本的持续下降,使得"全球化"传播成了可能;4、传播技术的全球化,加剧了国际传播的"不平等",导致了国际传播的层级性和不均衡分布;5、"冷战"的终结解构了东西对立,但却并未终结南北差异和"文明的冲突";6、人口的重新分布使得相关区域的传统意义上的民族国家面临潜在的不稳定,并有可能影响到原来各个国家已经定型的民族文化认同;7、"全球化"传播加深了民族国家精英知识分子的戒心,"守望民族传统文化的精神家园"的使命感使得他们开始关注核心的"传统文化"(具体包括传统的信仰、价值观、文化模式等)的有可能被颠覆或被恶意改造;8、"方向"与"策略"的有机结合,使得大型跨国传媒公司所向披靡,在发展中国家屡屡得手,很多国家出现了"祖母的同质化"现象;9、"地球村":神话还是现实?

This paper gave the detailed reviews on previousresearch results on subdrainage home and abroad,studied the effect and mecha-nism of subdrainage facilities on drainage,waterlogging reduction,salt removeas well as nitrogen fertilizer application under subdrainage conditions by use oflysimeter experiments and field trials.Numerical modelling on water movementin heterogeneons multilayered soils as well as the optimization layout of spacingsand depths of PVC subdrain was also investigated in this paper by numerical sim-ulations.

本文在论述国内外暗管排水研究进展的基础上,采用蒸渗仪控制试验,田间试验和数学模型数值计算相结合的方法,对塑料暗管的排水、降渍、除盐效果及其机理和塑料暗管排降条件下小麦的N肥运筹进行了深入研究,并对排降条件下试区非均质分层土壤水分运动的数值模拟和塑料暗管埋深和间距的经济优化布局模式进行了探讨。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

聚光:照片上是建在西班牙桑路卡拉马尤城的一座新型PS20塔式太阳能电站。被称为&日光反射装置&的镜子将太阳光反射到主塔,然后用聚集的热量产生蒸汽进而通过涡轮机转化为电力