结合紧密的

Truncation mutations in the adenomatous polyposis coli protein are responsible for familial and sporadic colonic tumours. Except for its function as a role in regulating b-catenin, recent studies show that APC has additional roles in cytoskeletal regulation. It binds to microactin and microtubules directly and indirectly. Furthermore, APC plays an important role in mediating the detraction of chromosome.

编码APC蛋白(adenomatous polyposis coli， APC)基因的缺失突变会导致家族性和散发性的结肠癌，APC蛋白除了能直接参与Wnt信号途径调节b-catenin的浓度之外，最近的研究表明APC蛋白能够与细胞骨架的主要成分微管和微丝直接或间接结合，通过调节微管的解聚和聚合，间接调节染色体的分离，作为潜在的细胞骨架调节分子将细胞骨架与重要的细胞信号转导通路紧密联系在一起。

Firstly,it reviews the history of aesthetic disinterestedness.

论文以三个命题阐述康德美学与中国现代美学的内在关联：首先，回溯审美无利害的历史，结合中国传统美学，从审美态度、艺术独立的角度阐明审美无利害命题的重要作用，审美无利害性既奠定了现代美学学术的独立性，又揭示出现代美学的基本性质与特征；其次，诠释康德美学中的审美自由概念，在现代美学的语境中阐释了"美是道德的象征"的命题，同时阐明审美游戏与美育的自由特征，审美自由显示出现代美学的超越精神和乌托邦精神；第三，艺术的人生观或者人生的艺术化将艺术与人生紧密地联系起来，审美人生展示出现代美学的审美理想，成为现代美学的价值归宿。

This paper determines the design idea of combining VISC with structural optimization design. Problems which existed in structural optimization design are analyzed and contents of optimization process are determined. Calling and dominating calculation program written in FORTRAN in the development environment of Delphi are realized by the techniques of FORTRAN/Delphi mixed-language programming and multi-threaded application. Parallel coordinates visualization technology is deeply researched and applied in software exploitation of optimization process. Essential programs of VISC software are compiled. Approaches which can improve efficiency of optimization are discussed. In the end, functional modules are integrated and a typical computational example is verified.

本文通过对结构优化设计和科学可视化的研究，确立了天线结构优化设计与科学计算可视化技术紧密结合的思路；根据天线结构优化设计的特点，针对优化设计中存在的问题，对系统结构优化的总体框架进行了分析和论述，确定了优化过程可视化的具体内容；通过FORTRAN与Delphi的混合语言编程实现了在Delphi环境下对FORTRAN计算程序的调控，充分利用了原有FORTRAN程序资源；对平行坐标技术进行深入研究，并将其应用于优化过程可视化模块的软件开发中，实现多维数据空间的可视化；编写优化计算过程可视化软件的核心程序；探讨了提高优化效率的途径；对基于可视化的天线结构优化设计软件系统进行集成，针对某天线进行了算例验证。

How to choose strategies of handing traditional culture down is an unavoidable subject in the new situation. The author of the article thinks that clothing, which is believed to be the visiting card of a people, should be simple with symbolization, pictorialization, totems and commercialization. Handing down of the living culture should be combined with ecosystem environments and places of interest to develop its content step by step. One cultural item should be exploited in one place to keep it alive forever. We should make good use of educational, research and translating organizations, media and the Internet to propagandize old and new characters and works. Some museums should be built up to protect metallic and stone relics. Setting up ecological museums or cultural villages and parks is an effective method. We should find out a new way in which key points about the understanding of the culture are explained clearly, core advantages are developed and cutlural labour force and propaganda work are revived The most important thing is to make complete use of the laws and policies on minority self-rule to find out the best way to keep Yi's traditional culture alive.

作者认为，作为民族身份"名片"的服饰应以简明为原则尽量符号化、图案化、图腾化、商业化；作为活文化的仪式与习俗的传承，除了在经济发展的前提下以村寨为基本单位尽量保护和弘扬，要尽可能与生态环境和旅游胜地紧密结合进行单个文化主题的念珠式贯串开发，一地深入开掘一个文化内蕴，使之可以传之久远；依托教育、科研、翻译机构和文艺传媒、互联网传承新老文字及典籍文化，建立文博场馆保护金石文物；建立民族生态博物馆或民族文化村文化园等也不失为一种有效的方式；译解文化传承基因，培育核心发展优势，形成文化再生力传播力，是一条应该认真探索的道路；最重要的是要充分利用好民族区域自治政策法规，使之发挥的效益最大化，并从法律和政策上寻求最佳的传统文化传承策略。

On the basis of realizing the innovation of enterprises' management mechanism, adjust and optimize the structure of the cocoon and silk industry's distribution pattern, lead the raw material production and the original processing industry's shifting to the central and western regions from the eastern area according to the plan step by step, realize the silkworm industry's transformation to advantage areas, from disperse to intensify and keep appropriate scale; The combination between the western and eastern areas must have complementary advantages each other, the process ability, fund, technology, market and management in the east, combine with the cheap labor force and ihe abundant resource in the west, will form the industry chain of the close connection, step on the route of division of tabor on the basis of specialization, area overall arrangement, laige-scale production, industrialization management, develop high-quality-cocoon,top-grade-silk, refinement silk fabric, manufacture our country's cocoon and silk industry's key competitiveness together, form the scientific and reasonable, high-efficient and continuate industrial development pattern.

在实现企业经营机制创新的基础上，调整和优化茧丝绸产业布局结构，有计划、有步骤地引导茧丝绸原料生产与原料初加工工业由东部地区向中西部地区转移，实现蚕业生产由一般区域向优势蚕区的转移，由零星分散向适度规模、集约化方向转变；东西部强强联合，优势互补，东部的资金、技术、市场、管理、产后加工能力，与西部丰富的资源和劳动力成本低廉的优势相结合，形成紧密联结的产业链，走专业化分工、区域化布局、规模化生产、产业化经营、发展优质茧、高档丝、精品绸的路子，共同打造我国茧丝绸产业的核心竞争力，逐步形成科学合理、高效、可持续发展的产业格局。

Xie Juezai transferred ancient topics of "running routine by one s own" and " asking others to work " into modern language fitting the context of time and environment as routinism and bureaucratism, at the same time, he combined the idea closely with the leadership style of that time, so to reflect and develop political and legal tradition systematically with reality.

谢觉哉将"躬亲庶务"与"委任责成"这一古老的话题，转换成当时革命队伍中通行的事务主义与官僚主义等通俗易懂的语言，并使其与我党当时进行的领导作风建设紧密结合起来，系统而自觉地对古代政治法律传统作了有价值的反省和发挥，将其与现实贯通起来，这本身就是一个创举；而更难能可贵的是，谢老并不拘囿于自己最初贬低"委任责成"的看法，而是在实践中转而肯定"委任责成"的价值和功能，修正了自己的观点、提升了自己的认识，表现出追求真理的严谨学风和工作作风；谢老是我党注重领导方式问题研究与实践的先行者和实践家。

In the first part, the opinions and ideas from some main figures concerning the North-western regions in modern history; In the second part, the process of three vital stages(Yang-Wu Movement, the "New Deal" in the last period of Qing Dynasty, Anti-Japanese War) are studied, and the characteristics of each stage are generalized falling into four categories, such as: military、feudal、comprador and nation-monopoly etc; In the third part, four reasons of the low efficiency of the industrial and mineral exploration are explored, they are the dominant role natural economy, the low level of productive forces, the science and technology, lack of capital accumulation and investment, lack of systematic policies and support from the government, In a word, as Mao Tsetung said:"It"s impossible to get rich, develop industry, strengthen national defence in semi-colonel and semi-feudal China.

全文共分四部分，第一部分论述了近代一些主要的阶级关注西北的言论和思想；第二部分对西北近代工矿业开发的三个最重要的阶段，即洋务运动时期、清末"新政"时期、抗日战争时期的开发过程做了梳理，并对每一个阶段的特点做了初步地概括，大致可以归纳为军事性、封建性、买办性以及国家垄断性等；第三部分对西北近代工矿业开发成效不高的原因做了论述，主要有四点：第一，小农业与家庭手工业紧密结合的自然经济占统治地位；第二，生产力水平低下，科学技术落后；第三，缺乏资金的积累和投入；第四，缺乏政府系统的政策支持和保障。

The latter three strategies are new and also the paper's three innovative points. First of all, appeal the law to prohibit reversed payment, unify this with the BOLAR exception, and promote the drugs into the market as soon as possible. Secondly, put the public health, medicine patent and the IPRs protection of traditional knowledge and the genetic resources together. Through giving the traditional knowledge and the genetic resources IPRs protection to treat the developed countries' medicine patents, they can settle the public health crisis. Finally, the legal mechanism of Prior Consent is a new strategy that Brazil proposed for the purpose of protecting the public health, which divides the examination of patent applications for pharmaceutical products and processes between two federal agencies, National Institute of Intellectual Property and National Sanitary Supervision Agency. ANVISA has the obligation to render the final decision, granting or denying a patent.

其中前四种措施是国际社会上一直以来倡导的主要措施，后三种是新的解决公共健康危机的法律措施，其创新点在于：第一，呼吁将禁止反向支付纳入法律，并与BOLAR例外相结合使用，促进仿制药品的尽快上市；第二，将公共健康、医药品专利以及传统知识和遗传资源的知识产权保护三者紧密相连，通过对传统知识和遗传资源予以知识产权保护来应对发达国家的医药品专利；第三，&事先同意&法律制度是巴西提出的一种旨在保护公共健康，应对医药专利的新的法律制度，该制度规定凡是涉及医药品专利的申请都必须经过国家知识产权局和国家公共卫生监督局的公共审查，并且国家公共卫生监督局有是否授予专利的最终决定权。

Combining traditional Chinese ink and brush techniques with the spirit of Western surrealism, his paintings are poetic mysteries, cerebrally enticing and visually arresting with their saturated ink and color palette and fusion of symbolic motifs from Eastern and Western painting traditions.

他的画将中国传统的墨汁和毛笔的运用技法与西方的超现实主义紧密结合，用其饱满的墨和色彩的调和融合了东西方绘画传统的象征性的主题，其作品充满了诗意的神秘，触动灵魂的诱惑力以及视觉上带给人们的强烈冲击力。

The most innovative idea of this paper is to complect the mobile detection of Mobile IPv6 and VPN detection. This makes the mechanism more efficient and easy to implement, what's more, the solution is compatible with IPv4/v6 coexistence condition.

本文的创新之处是充分考虑了未来NGN的发展，率先采用移动IPv6作为移动VPN的移动性支持，并将移动IP的移动检测与VPN检测紧密结合起来，最大限度的达到准确高效的目的，同时又获得了针对IPv4/v6共存网络环境的支持，本文中的内部网络检测机制已经向国家专利局申请专利(申请号200610058450.1)。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。