结合物

At the same time, such protein molecula alterations would be useful to discover the important influence of heme axial ligands on the protein's structure and properties.

为了实现细胞色素b〓的人工设计和分子改造，通过蛋白质工程方法打破这种均衡的六配位结构，创造出可能的底物结合空穴，将可望构建出具有催化活性的新金属蛋白分子。

It formed a stable complex with trypsin at 1:1 moler ratio.

它以1：1摩尔比同胰蛋白酶形成稳定结合的复合物。

The present invention discloses a polycarboxylic acid copolymer which is obtained by copolymerization of monomer components comprising a polyalkyleneimine unsaturated monomer (A2) and an unsaturated carboxylic acid monomer, the polyalkylene glycol unsaturated monomer (A2) having an oxyalkylene group bonded to a polyhydric alcohol residue, and the monomer component containing an unsaturated monocarboxylic acid monomer.

公开了一种多元羧酸共聚物，它是通过单体组分共聚制得的，所述单体组分包括聚二醇不饱和单体(A2)和不饱和一元羧酸单体，所述聚二醇不饱和单体(A2)具有使氧化烯基结合到多元醇残基上的结构，所述多元醇残基平均每个分子具有不少于3个羟基。

Recently, a variety of regulatory proteins including DNA methyltransferases, methyl-CpG binding proteins, histone-modifying enzymes, chromatin remodeling factors, and their multimolecular complexes have been identified.

最近，包括DNA转甲基酶，CpG甲基化结合蛋白质，组蛋白修饰酶，染色质重构因子，和它们的多分子复合物等各种调控蛋白质被识别。

During our strategy, two linear amplification approaches are employed, ligase detection reaction and an isothermal amplification (cooperation by DNA polymerase and nicking enzyme).

连接产物由于在DNA聚合酶和限制性内切酶的共同作用下，发生等温扩增反应，扩增出大量的血红素的适配子，适配子与血红素结合，形成的复合物催化鲁米诺和双氧水的化学反应。

The ru1es of crystal parameters varing with the scale of nonfreedom were found out. Spectrum series were theoretically interpreted as well.

经过初步研究表明，金属蛋白中，金属离子与氨基酸结合，可以通过金属离子和氨基酸配合物的结构得到指示。

Upon binding ATP or a nonhydrolyzable analog such as AMPPNP, RecA undergoes an allosteric transition into a high-affinity DNA-binding form. When RecA combines with dsDNA to form RecA-dsDNA nucleofiliment, it can unwind dsDNA and change the dsDNA structure.

在ATP或其类似物的辅助下，RecA可以直接与双股DNA结合而形成核丝，并将双股DNA加以解螺旋，并改变双股DNA的结构。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

Lanthanum orthovanadate nanorods were synthesised by a template-directing hydrothermal method.

采用水热法和模板导向法结合的方法合成钒酸镧纳米棒，通过XRD、SEM、TEM对产物的物相、结构和形貌进行表征，并测试了其光学性能。

Based on the GIS theory, using the the overlayer algorithm of hierarchical maps in GIS method, through the corresponding constraint condition, Fuzzy Similarity Nearness degree matter-element model is applied to the flood disaster moves the plan to carry on the synthesis judgment the method.

本文试图利用模糊综合评判方法，结合GIS在洪灾避迁决策的应用，利用GIS图层叠加与空间分析的方法，通过相应的约束条件，筛选出满足约束条件的约束集，利用模糊相似贴近度物元模型进行方案的评价决策。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。