结合物

Objective This study was aimed at optimizing the preparation of 5-Fluorouracil and peanut agglutinin conjugates so as to obtain a conjugate with high activity and high drug ratio, and to choose a suitable dosage form in the light of its properties.

目的 优化5-氟尿嘧啶(5-Fu)-花生凝集素结合物的反应条件，以期制备得到既有生物活性又有较高药物结合率的结合物。

The hydrophobic value of Fuchs\' model of humic acidsand Alvarez\'s model of fulvic acids which combined with metal icon smaller than the other molecularmodels; but the refractiveness, polarity, approximate surface, grid surface, volume, mass of the Felbeck\'smodel k of the humic acids and Buffle\'s model of the fulvic acids which interacted with the metal iconsmaller than the other molecular models.

综合比较结果表明：Fuchs—HA和Alvarez—FA与金属离子结合物的疏水性小于其他它腐殖酸分子；Felbeck-HA和Buffle—FA与金属离子结合物的折射性、极性、近似表面积、栅格表面积、体积、质量同比小于其它腐殖酸分子。

The aluminium oxyhydrogen adjuvant could increase the IgG titer to Pncps caused by the Pncps-protein conjugant, very notably increase the IgG titer to protein and to conjugant itself caused by conjugant.

氢氧化铝佐剂能增加多糖－蛋白结合物诱生的抗多糖IgG抗体滴度，极其显著地增加抗蛋白及抗结合物自身的IgG抗体滴度。

Results Both GAMP derivatives and GAMP-protein conjugates showed GAMP antigen specificity. Compared with GAMP alone, the GAMP-protein conjugates induced high serum anti-GAMP IgG antibody level and strong bactericidal activity in vitro. The conjugate also induced immunological memory.

结果 多糖衍生物、多糖－蛋白质结合物均具有GAMP抗原特异性；结合物免疫小鼠可诱生较单独多糖更高水平的血清抗GAMP IgG抗体和更强的体外杀菌活性，并能产生免疫记忆。

In pH2.5 potassium hydrogenphthalate buffer solution, a supermolecular can be developed betvveen Cu-TZAMB complex and DNA, which can decrease the cathodic peak of this complex. This supermolecular complex was testified to be intercalating bound to the DNA by cyclic voltametric method, salt effect and the UV-VIS spectra.

通过循环伏安法、盐效应以及紫外-可见吸收谱证实了是由Cu-TZAMB络合物与DNA形成一种插入式的电惰性结合物而使其峰电流下降。

In this paper, purification of growth hormone receptor from ovine liver and identification of its biochemical character have been done.Firstly, by homogenizing, triturating, high-speed centrifuging, hypervelocity centrifuging and sucrose density grade centrifuging cell membrane of ovine liver was separated and its electron microscope slice wasprotein was disL~olved with TritonX-100,amL-thebinding activity between cell membrane or membrane protein and ~I-hGH using RRAwas measured, perfect saturated curve wasgained. Thirdly, specific binding of GILR protein was measured ,by SDSPAGE, its molecular weight is about 1 19KD.

本研究采取新鲜羯羊肝脏，匀浆、研磨，经高速离心，超速离心和蔗糖密度梯度离心，分离肝脏质膜，得到肝脏质膜的电镜切片：其次，用去垢剂TritonX-100增溶膜蛋白，利用放射受体分析法，测定细胞膜及膜蛋白与~(125)I-hGH的结合活性，均得到理想的饱和曲线；再次，将两点结合试验法与凝胶层析法结合检测到特异结合物，然后，经SDS-PAGE电泳分析，纯化后的样品呈现一条带，与标准分子量比较，得出分子量为119KD。

To improve the effect of CDCA on dissolving cholesterol gallstone, the water-soluble copolymers as polycarboxylic acid of comb-like copolymers and C_(60)-PCC were synthesized, which being used for modification of CDCA and strengthening effects of CDCA on dissolving the cholesterol gallstones by their entropy-repelled properties of comb-shaped side chains in buffers of phosphate and in model bile.The design theory of polymer was mainly employed to synthesis the conjugate of PCC-CDCA and C_(60)-PCC-CDCA by C_(60), polyoxyalkylene allylalkyldiether and maleic anhydride, which were copolymerized with AIBN as initiator, and then PCC or C_(60)-PCC were reacted with CDCA. The structures of the copolymers and the conjugates of PCC-CDCA and C_(60)-PCC-CDCA were confirmed with IR, TLC and TEM. The dissolving effects and the dissolution kinetics mechanism of cholesterol gallstone was inverstigated in PBS and in model bile of different cholesterol saturated index at pH7.4, including PCC-CDCA or C_(60)-PCC-CDCA.

利用高分子设计理论，以烯丙基聚氧乙烯基醚、顺丁烯二酸酐、C_(60)和CDCA为原料，以偶氮二异丁腈为引发剂，合成具有梳状侧链结构的梳状共聚物-CDCA结合物和C_(60)-梳状共聚物-CDCA结合物，以IR、TLC和TEM法表征共聚物的结构，并在pH7.4的PBS液和不同胆固醇饱和指数的模拟胆汁中进行溶石效果的研究，探讨在PBS液和不同CSI的模拟胆汁中结合物溶解胆固醇结石的效果和溶解动力学机制。

In vitro time-killing studies, the combination of PEI-amphotericin B and PEI-fluconazole enhanced antifungal activity, but there was an antagonist for the combination of PEI-polymyxin B.

在体外致死研究实验中可以看到，PEI-两性霉素B和PEI-氟康唑结合物可以提高抑菌作用，但PEI-多黏菌素B结合物却拮抗抑菌作用。

In vitro time-killing studies, the combination of pei-amphotericin b and pei-fluconazole enhanced antifungal activity, but there was an antagonist for the combination of pei-polymyxin b.conclusionspei alone and in combination with amphotericin b and fluconazole displayed the high antifungal activity against candida albicans.

在体外致死研究实验中可以看到，pei-两性霉素b和pei-氟康唑结合物可以提高抑菌作用，但pei-多黏菌素b结合物却拮抗抑菌作用。结论 pei单独与联合使用均对白念珠菌产生很好的抗菌效果。

The Pncps-protein conjugants prepared were helpful to promote the transfer of the classes of antibody to Pncps from IgM to IgG in serum. Under our experimental conditions, when the usage of Pncps was identical in the conjugants, the more protein conjugated, the more IgG titers to Pncps and to protein were observed.

本实验制备的荚膜多糖－蛋白的结合物中，相同多糖用量情况下，蛋白用量的增加能够促进血清中抗多糖抗体类型由IgM向IgG转变，分别提高结合物抗多糖、抗蛋白IgG抗体滴度。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。