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KIR bind corresponding HLA-Ⅰmay hame four results followed:1、When inhibitory KIR bind HLA-Ⅰand there has no activatory KIR bind it,cell isn\'t dissolve because inhibitory signal access was done;2、When activatory KIR bind corresponding HLA-Ⅰand there has no inhibitory KIR bind it,form activate signal,lead cell dissolve.3、If activatory or inhibitory receptor both bind HLA-Ⅰ,both signal access is make done,when activatory signal play the main role,NK cell still actived,lead target cell dissolve.4、If activatory or inhibitory receptor both bind HLA-Ⅰ,both signal access is make done,when inhibitory signal play the main role,or both signal access don\'t play,NK cell do not make effect.this is NK cell recognice nomal tissue.

与活化型KIR受体相比,抑制型KIR受体与HLA-Ⅰ类抗原结合的亲和性更强,当抑制型和活化型KIR受体识别和结合同一HLA-Ⅰ类抗原分子时,以抑制作用为主。KIR与相应HLA-Ⅰ结合后可能产生以下4种情况:①当抑制型KIR与HLA-Ⅰ结合而无活化型KIR与HLA-Ⅰ相互作用时,因抑制信号通路启动而不产生细胞溶解;②当活化型KIR与靶细胞表面的相应HLA-Ⅰ结合同时无抑制型KIR与HLA-Ⅰ的相互作用时,形成刺激信号通路,导致靶细胞溶解。

Then, the system is linearized by variational approach, the local null controllability is proved by applying a generalized implicit function theorem and combining the good property of the solution mapping.

首先通过对系统线性化,构造泛函,利用对偶方程,给出控制函数具体形式的办法得到系统的逼近能控性;然后采用变分方法对系统线性化,再结合解映射好的性质,应用推广的隐函数定理,证明系统的局部零能控性;最后利用局部零能控性和逼近能控性结合给出系统零能控的结论。

First of all, the basis of the MRTD method is studied. In Chapter 2, wavelets analysis and multiresolution analysis, the mathematical basis, are introduced, and the characteristics of the wavelets basis functions, including orthonormality, compact support, multiresolution and so on, are also introduced. The advantages of the applications of these functions to the numerical electromagnetic calculations are discussed. In Chapter 3, the algorithm basis of MRTD: the combination of the wavelets and the method of moments is studied. This Chapter shows that the MoM based MRTD method is the combination of wavelets and MoM using Galerkin sampling.

文中首先讨论了 MRTD 的建立基础,其中第二章介绍了其数学基础-小波分析及多分辨分析,讨论了小波基函数的性质包括正交性、紧支撑性、多分辨性等及其应用于电磁场数值计算的优势;第三章讨论了其算法基础-小波与矩量法的结合,阐述了以矩量法作为算法基础,以 Galerkin 离散采样的方式与小波函数结合而产生了 MRTD。

First of all, the basis of the MRTD method is studied. In Chapter 2, waveletsanalysis and multiresolution analysis, the mathematical basis, are introduced, and thecharacteristics of the wavelets basis functions, including orthonormality, compactsupport, multiresolution and so on, are also introduced. The advantages of theapplications of these functions to the numerical electromagnetic calculations arediscussed. In Chapter 3, the algorithm basis of MRTD: the combination of the waveletsand the method of moments is studied. This Chapter shows that the MoM basedMRTD method is the combination of wavelets and MoM using Galerkin sampling.

文中首先讨论了 MRTD 的建立基础,其中第二章介绍了其数学基础-小波分析及多分辨分析,讨论了小波基函数的性质包括正交性、紧支撑性、多分辨性等及其应用于电磁场数值计算的优势;第三章讨论了其算法基础-小波与矩量法的结合,阐述了以矩量法作为算法基础,以 Galerkin 离散采样的方式与小波函数结合而产生了 MRTD。

HA increased level of NO by activating NOS after combining with H〓 and H〓 receptors; and on the one hand 5-HT caused brain microvessel endothelial cells constracting strongly, made the tight joint opening, increased the permeability of BBB, and on the other hand 5-HT increased the quantity of pinocytosis vesicle in endothelial cells and enhance the permeability of BBB after comining with 5-HT〓 receptor.

HA与H〓和H〓受体结合,激活NO合成酶,使NO含量增多而诱发BBB通透性增加;5-HT与5-HT〓受体结合,一方面引起脑微血管内皮细胞强烈收缩,使内皮细胞间的紧密连接开放,BBB通透性增高,另一方面可引起内皮细胞转运小泡增加,BBB通透性增高。

Membrane affinity quantified by IAM and liposome/buffer systems was a more efficient predicator of α values than hydrophobicity from n-octanol/buffer system. Consequently, not only hydrophobic force but also attractive polar extra-interactions involved in the binding to IAM and liposomal membranes but not in an n-octanol phase, ascribed to the binding process within AM. The binding to ordered lipid membrane in the larger part determined drugs'binding to AM intracellular compositions, and the ordered phospholipid plasma membrane was a potential site for drugs'binding in AM.

脂质体/水系统和磷脂膜色谱所测定的膜亲和性比正辛醇/水系统的疏水性更好的预测巨噬细胞内药物的α值,因此包含在磷脂膜色谱中但并不体现在正辛醇/水系统中药物与磷脂膜之间的额外吸引性极性作用力对药物在细胞内结合有着重要贡献;药物与有序磷脂膜的结合在很大程度上决定着药物与巨噬细胞内成分的结合,有序磷脂分子膜可能是巨噬细胞内部潜在的结合部位。

Teacher-Student Double Subject Principle is an important precondition for title selection of Chinese Integrated Learning. II. Feasibility Principle is the value of title selection of Chinese Integrated Learning. III. The combination of multi-subject and uni-subject principle is an unexhausted headspring for title selection of Chinese Integrated Learning. IV. The linguistic nature of title selection target is not only the jumping-off place for title selection of Chinese Integrated Learning, but it is also the end-result for title selection of Chinese Integrated Learning.

本文主要运用文献资料与实例相结合的方法,注重于理论与实践的结合,重点探讨了义务教育阶段语文综合性学习的选题指导原则:第一,师生双主体性原则是语文综合性学习选题的前提;第二,可行性原则是语文综合性学习选题的价值所在;第三,开放性与学科性相结合是语文综合性学习选题的重要规则;第四,选题目标的语文性是语文综合性学习选题的出发点,也是语文综合性学习选题的归宿。

The predicted amino acid sequence of the gene show a rather high homology(84.47% amino acid identities)with Haemaphysalis longicornis(H.longicornis) TnI (GenBank,GI:14041807).Furthermore, the actin-binding domains of troponin I in predicted amino acid sequence, just the same as H. longicornis ,at the amino acid residues 147-167, suggesting the gene is K haemaphysaloides TnI gene.

经同源性比较,该基因预测的氨基酸序列与长角血蜱肌钙蛋白Ⅰ(GenBank,GI:14041807)有很高的同源性(同源性为84.47%),肌动蛋白结合位点位于147-167氨基酸处,且与长角血蜱肌钙蛋白Ⅰ肌动蛋白结合位点完全相同,表明该基因是镰形扇头蜱肌钙蛋白Ⅰ基因。

Chapter 5, from a cognitive point of view and integrating the analytical points covered in the previous chapters, examines the metaphoric nature of intentional humor which serves in a sub-discourse as ideational and/or interpersonal means of rhetoric under the global discourse of public speaking, with case analyses of such humorous metaphors, standard or non-standard, at the word, sentence, and discourse levels as well as at the meta-level, and with the idea of resemblance proximity to classify humorous metaphors into synecdochic, metonymic and metaphorical types.

第五章从认知语义的角度并结合前三章的分析来讨论公众演说者有意幽默的隐喻性,考察标准和非标准幽默隐喻在词汇、句子、话语层面以及在元层面的表现,并结合演说语料的个案分析考察幽默隐喻作为次话语在演说整体话语中所达到的概念修辞和人际修辞效果。基于隐喻的相似度,本章还将幽默隐喻进一步分类为借代性幽默、换喻性幽默,和隐喻性幽默。

A 1: Uninduced supernant of cell lysate by sonication; 2: Induced supernant of cell lysate by sonication; 3: Uninduced precipitate of cell lysate by sonication; 4: Induced inclusion body of cell lysate by sonication; 5: Purified ULBP4 protein; M: Low molecular marker proteins.

2.3 体外NKG2D结合实验和细胞因子分泌实验间接ELISA检测结果显示:原核表达复性后的ULBP4能与人NKG2D结合,而带His标签的无关蛋白则不能与之结合,说明复性后的ULBP4仍能维持正确的天然构像。

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