结合

However, fully consideration of special structure and physiological function of CRP is critical to investigate whether CRP provide protect effect or pathogenic effect in the progression of atherosclerosis. CRP is a member of pentrxins family, which consists of five identical, noncovalently associated 23-kDa protomers arranged symmetrically around a central pore with a 102 A external diameter. Each protomer has a recognition face with a phosphocholine binding site consisting of two coordinated calcium ions adjacent to a hydrophobic pocket. The opposite face of the pentamer is the effector face, where complement Clq binds and Fc receptors are presumed to bind. A cleft extends from the center of the protomer to the central pore of the pentamer. Both faces ofpentamer form a special bi-phase structure: one face is the ligand recognition phase, which can recognize apoptosis cells and enzyme modified low density lipoprotein in which PCh is exposed.

CRP是一种五聚体蛋白，外径为102 A，由5个相同的单体以非共价键结合，形成双面的环形结构，每个单体的配体识别位点或受体结合位点分别位于五聚体两个平面上，分别组成配体识别相和效应器相，从而构成特殊的二相性结构：一面为配体识别相，含有磷酸胆碱(phosphorycholine，PCh)结合位点，能够使CRP识别在病理条件下暴露出PCh的凋亡细胞、酶修饰低密度脂蛋白(enzyme modified low density lipoprotein，E-LDL)等。E-LDL是天然低密度脂蛋白(native Low density lipoprotein，N-LDL)在多种蛋白酶，如胰蛋白酶、神经氨酸酶、胆固醇酯酶等作用下的代谢产物，其主要特点是结构发生改变(N-LDL大小均匀，平均直径250±30 A，E-LDL大小差异极大，直径为100-2000 A)，暴露磷酸胆碱位点，能够被CRP识别；另一面为效应器相，能够与巨噬细胞、单核细胞表面受体FcγRⅡa结合，介导巨噬细胞、单核细胞识别及吞噬凋亡、坏死细胞作用。

This research achievements is the result at the base of field geologic data colligating with the data of some drilling and seismic, and of the combining of sedimentology and tectonic geology researches, theory and practice researches, actual measurement of skeleton sections and observation of complemented sections, macroscopical studies and microcosmic studies. The classification and characteristics of sedimentary system and the genetic types and expression form are systematically analyzed in the thesis, and the division scheme of the Youjiang basin is put forward.

研究成果是以大量的野外地质资料为基础，综合了部分钻井和少量地震等资料，采取沉积研究和构造研究相结合、理论研究和实际研究相结合、实测基干剖面与补充观察剖面研究剖面相结合、宏观研究和微观研究相结合的方法，系统地分析了右江盆地的沉积体系种类和特征、层序界面的成因类型和表现形式，进而提出了右江盆地的层序划分方案。

Skill-mental dominated event-group has characteristics what are polarizing frighten goal and fluctuating variation course. 6 Coaches and athletes must insist on the principles that is comminuting of judging accurately and intervening in good time, perspective with getting practical to combine together, timeliness and synchronous combine together, controllability and principle that substantial results combine together.

影响竞赛过程中运动员竞技能力变异的众多因素可聚合为以下四个相对独立又相互联系的子系统，即：运动员的竞技状态与相对竞技实力、参赛认知水平与比赛经验、可逆转环境和中立环境。4运动员竞技能力的参赛变异具有变异成因的多元性和多变性、变异内容体能的先导性、变异过程的可控性与非可控性、变异结果的两极性和层次性和参赛行为的心态易变性等五个方面的一般训练学特征。5体能主导类项群具有变异结果直观性、变异过程连续性和对手制约两重性等特征；技能主导类项群具有单项贡献制约性、个体变异传递性和裁判评定诱导性等特征；技战能主导类项群具有群体整合共生性、核心技战术制导性、攻防转换制约性和局盘赛点突增性等特征；技心能主导类项群具有目标恐惧极化性和变异过程波动性等特征。6教练员、运动员必须坚持准确判断和适时干预相结合、前瞻性与务实性相结合、适时性与同步性相结合、可控性与实效性相结合的原则。

To this end, the author starts from the perspective of relevancy between city and region and then gleans theories and approaches from relevant disciplines such as economic geography、urban geography、urban sociology. By reviewing the research achievements at home and abroad and incorporating theoretical research and empirical study, dynamic process and comparative static analyses, quantification and qualification, comparative study and synthetic integration, it concludes by putting forward the theoretical framework and major elements in influencing spatial diffusion, functions and structures.

因此，本文的研究主要从城市和区域关联的角度，综合运用经济地理学、城市地理学、城市社会学等多种学科的理论与方法，在总结国内外研究成果的基础上，采用理论研究和实证研究相结合、动态过程研究和静态比较研究相结合、计量研究和定性研究相结合、比较研究和综合集成相结合的方法，对城乡融合区发展理论和城乡融合区空间发展理论进行了深入的研究和总结，提出了城乡融合区的理论框架，城乡融合区空间扩展的主要影响因素以及结构功能。

In this paper, purification of growth hormone receptor from ovine liver and identification of its biochemical character have been done.Firstly, by homogenizing, triturating, high-speed centrifuging, hypervelocity centrifuging and sucrose density grade centrifuging cell membrane of ovine liver was separated and its electron microscope slice wasprotein was disL~olved with TritonX-100,amL-thebinding activity between cell membrane or membrane protein and ~I-hGH using RRAwas measured, perfect saturated curve wasgained. Thirdly, specific binding of GILR protein was measured ,by SDSPAGE, its molecular weight is about 1 19KD.

本研究采取新鲜羯羊肝脏，匀浆、研磨，经高速离心，超速离心和蔗糖密度梯度离心，分离肝脏质膜，得到肝脏质膜的电镜切片：其次，用去垢剂TritonX-100增溶膜蛋白，利用放射受体分析法，测定细胞膜及膜蛋白与~(125)I-hGH的结合活性，均得到理想的饱和曲线；再次，将两点结合试验法与凝胶层析法结合检测到特异结合物，然后，经SDS-PAGE电泳分析，纯化后的样品呈现一条带，与标准分子量比较，得出分子量为119KD。

The Scatchard analysis of data revealed a linear relationship between the amount of specific binding and the ratio of specific binding to free 125 I (D Lys 6)LHRH, indicating a single class of high affinity sites. Equilibrium dissociation constant was 0 34 nM in pituitary membrane preparation and 0 43nM in isolated pituitary cells.

特异性结合随125 I( DLys6 ) LHRH 量的增加而增加，实验结果经Scatchard 分析揭示出特异性结合与结合和游离125I( DLys6)LHRH 之比呈线性关系，预示绍鸭垂体对( DLys6)LHRH 存在同一类高亲和力的结合位点。

The second part of the paper introduces "the background of Chopin"s creation of piano Etude. Then through the comparison of his and the people of his time or before on Etudes, the paper concludes that Chopins" has broken the traditional meaning on this genre. In the end, the paper analyses how Chopin"s Etudes combine art with technique, through three aspects: synthetical melody and technique, colorful harmony and technique, and singular piano and technique.

第二部分首先简要介绍肖邦钢琴练习曲的创作背景；接着通过肖邦练习曲与他之前和同时代的作曲家的练习曲的比较，说明肖邦的练习曲已突破了这一体裁的传统意义；最后从三个方面：综合的旋律特征和技术的结合、丰富的和声风格和技术的结合、独特的钢琴织体和技术的结合，来阐述肖邦练习曲是艺术性和技术性的有机结合。

The five prosthetic groups (FAD, [2Fe-2S], [4Fe-4S], [3Fe-4S] and heme group) required for electron transfer from succinate to ubiquinone were unambiguously assigned into the electron density map. Besides, we find there are some electron densities around the Qp pocket at the matrix side and we believe it represents the head structure of ubiquinone, which is proved by the inhibitor bound structure that 2-TTFA just locating at the Qp site. At the same time, we find there is the second 2-TTFA binding site, locating the inter-membrane side. This finding will change our knowledge about the electron transfer inside Complex II and the ubiquinone transfer between Complex II and Complex III, and endow a new role of Complex II in electron transfer chain.

除了对各个电子传递体（ FAD ，[2Fe-2S]，[4Fe-4S]，[3Fe-4S]以及血红素分子）进行精确定位外，我们在该结构跨膜区靠近线粒体基质一端的口袋 Qp 中，发现了一些电子密度，认为是所结合的辅酶 Q 的头部结构，这一点被与抑制剂结合的复合体的结构所证明，在该结构中， 2－ TTFA 恰好结合在口袋 Qp 中，同时，我们还发现了第二个2－ TTFA 的结合位点，位于跨膜区靠近线粒体膜间隙一端的口袋 Qd 中，这个发现具有全新的意义，将影响人们对电子在复合物 II 中传递以及辅酶 Q 在复合物 II 与 III 之间转移的认识，促使人们重新复合物 II 在线粒体呼吸链中的角色。

Pulse tracings have characteristics of complex system .

脉象具有复杂性系统的基本特征，将复杂性科学方法论的4条基本原则，即还原方法与整体方法相结合，微观分析与宏观综合相结合，静态分析与动态考察相结合，定性判断与定量描述相结合，尝试运用于脉诊现代研究中，提出&周期整体&假说。

According to Marxist side, point of view and method, especially under the guidance of Deng Xiaoping\'s theory, the author first explores and analyses the historical, cultural, social, economic and political sources of the hard-dying corruption, then suggests the following for its solution:"treating it by looking into both its root cause and symptoms","guarding against and attacking it","a quick campaign and a long-term strategy","construction of both material civilization and ideological civilization","comprehensive administration and elimination of its single parts" and eight specific measures. The dissertation emphasizes that corruption spreading trend can be put to an end gradually through comprehensive administration, by all available means at the same time, especially by taking into consideration initiating new policies and building the organ to guard and fight against corruption.

按照马克思主义的立场、观点和方法，特别是以邓小平理论为指导，对当前我国腐败现象久遏不止的历史文化根源，社会变迁根源，经济根源和政治根源等进行分析与探索，从而提出了标本兼治、打防结合、战役速决与战略持久相结合，物质文明建设与精神文明建设相结合、综合治理与专项清理相结合的总体思路和八条具体对策，着重强调应从制度创新和建立防腐反腐的机制上着手，多管齐下，通过综合治理，逐渐把腐败现象蔓延的势头遏制住。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。