经

Methods Starting from 2-chloro-4-nitrophenol and 2- pyridine hydrochlorid, 3-chloro-4-(pyridin-2-ylmethoxy) aniline was obtained via etherization and reduction. The obtained aniline coupled with N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide to give 4-[3-chloro-4-(2-pyridylmethoxy) phenylamino]-3-cyano-7-ethoxy-6-N-acetylaminoquinoline. And then it was deacetylated, followed by reacting with4- but-2-enoyl chloride to yield the target compound neratinib.

以2-氯－4-硝基苯酚和2-氯甲基吡啶为起始原料，经醚化、硝基还原得到3-氯－4-（吡啶－2-甲氧基）苯胺，3-氯－4-（吡啶－2-甲氧基）苯胺与3-氰基－6-乙酰氨基－7-乙氧基－4-氯喹啉反应得到3-氰基－6-乙酰氨基－4-［3-氯－4-（吡啶－2-甲氧基）苯氨基］－7-乙氧基喹啉，3-氰基－6-乙酰氨基－4-［3-氯－4-（吡啶－2-甲氧基）苯氨基］－7-乙氧基喹啉去乙酰保护基后，与-4-二甲氨基－2-丁烯酰氯经酰化反应得到ner-atinib。

After esterification, the ethyl-2-chloro-3-phenylpropionate reacts with diethyl malonate under the catalysis of sodium ethylate, and we obtain the corresponding triethyl ester. The-benzylsuccinic acid is formed by the triethyl ester reacting with concentrate hydrochloric acid and taking place hydrolyzation and decarboxylation reaction at the same time. In order to avoid the formation of cinnamic acid, the sodium ethylate and diethyl malonate must be react sufficiently. The course has simple operation, inexpensive materials and better yield.

具体制备工艺为：首先以L-苯丙氨酸为原料采用重氮化方法得到-2-氯-3-苯基丙酸，再经酯化得到-2-氯-3-苯基丙酸乙酯后在乙醇钠催化作用下和丙二酸二乙酯缩合，发生SN2反应，得到相应的三乙酯，然后经水解和脱羧，得到-苄基丁二酸；在实验中乙醇钠要和丙二酸二乙酯充分反应，避免生成肉桂酸乙酯；该过程操作简单，原料便宜，产率较高，总收率可达到26.8%。

The changes of proteins in the leaves of seedlings in Euonymus radicans treated at different duration of cold acclimation were analyzed by using 2-dimentional electrophoresis.

应用电导法，配以Logistic方程，测定了未经冷驯化和经冷驯化的金边卫矛幼苗的低温半致死温度，并测定了未驯化苗和驯化苗经各级冰冻温度处理后，在4℃恢复一天后的系列电解质渗出率。

For understanding the changeable regulation of burn wound invisible dehydration, directing the clinical treatment, with EPIC evaporimeter, We carried out observation on the local burn wound invisible dehydration of 25 cases who had different degree of burn depth and different burn area. The result showed:(1)In the first a few days after burning, the amount of dehydration through the surface of burn wound was larger than that of normal skin.

为了解湿性疗法经创面不显性失水的变化规律，以指导临床治疗，我们用蒸发仪对25例不同深度和面积的烧伤病人局部创面不显性失水进行了观测，结果表明：(1)烧伤后最初几天内，经创面蒸发丢失的水量要多于正常皮肤。

Methods 15 cases with low rectal cancer were operated with eversion and pull-through anus preserved colorectal anastomosis through anus.

对低位直肠癌经腹经肛门直结肠外翻拉出保留肛门吻合术15例。

This article is to exhume its academic achievement and develop it to ahigher degree and this, we think, will give some enlightenment to the modern studies of life sciences.......

本文发掘《黄帝内经》生命科学理论，旨在光大《黄帝内经》的学术成就，对现代生命科学的研究亦有一定的启迪作用。

Art of figuration of the protruding after classics skin centrum (Percutaneous Kyphoplas-ty, PKP) is to be in art of figuration of classics skin centrum (Percutaneous Ver-tebroplasty, the technology of small innovation of surgery of a rachis that the development on the foundation of PVP) rises, its fundamental is the buy inside preexistence centrum enters but expansile ball bursa , the dilate that carries ball bag forms a cavity inside centrum, again infuse stuff stuff, correct deformation thereby, achieve constrictive to a few osteoporosis or tumour centrum that bring about fracture (Vertebral Compressionfractures, the remedial purpose of VCFs).

梗概： 经皮椎体后凸成形术(percutaneous kyphoplas-ty，PKP)是在经皮椎体成形术(percutaneous ver-tebroplasty，PVP)的基础上发展起来的一项脊柱外科微创新技术，其基本原理是先在椎体内置入一个可膨胀性球囊(inflatable bone tamp，IBT)，通过球囊的扩张在椎体内形成一个空腔，再注入填充材料，从而纠正畸形，达到对一些骨质疏松或肿瘤等导致的椎体压缩性骨折(vertebral compressionfractures，VCFs)的治疗目的。

Methods TBNA and brushing biopsy were performed in 67 patients with mediastinal lymphadenopathy or with extrabronchial tumors,then the TBNA ang brushing biopsy were compared with the traditional ring clamp biopsy.

对经CT检查的67例纵隔淋巴结肿大和叶、段支气管腔外占位的患者通过经气管镜行针吸活检和刷检并与传统的常规钳取活检对照。

Objective To compare the usage effect of Patient Control Injection Ache and Patient Control Extradural Ache in open-chest operation patients.

目的比较经静脉注射病人自控镇痛和经硬膜外病人自控镇痛在开胸手术患者的应用效果。

The web paper is inputted by Mill Roll Stand, and after heated and regulating the moisture by the pre-heater, the paper is put into the Single Facer for shaping and then conglutinating with another top paper to form a single corrugated board. The single corrugated board is then transmitted by the overhead bridge conveyor to multiple heater to be reheated, after this the paper is to double facer for being heated and jointed, herein a continuous corrugated board is formed.

由原纸架输入卷形原纸，经过热缸机加热及调节湿度，进入单面瓦楞机，经过瓦楞机的滚轧成形，与另一面纸粘合成单面瓦楞纸，由天桥架传送，经多重预热器再次加热，经上浆机粘糊再至双面机加热贴合，此时连续的瓦楞纸板即已成形。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。