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This invention provides compounds of Formula; wherein: R is a moiety selected from the group: and n is an integer of 1 or 2; R is selected from hydrogen, amino,-NRR, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted, halogen, and a 5 to 10 membered heteroaryl ring optionally substituted, having 1 to 4 heteroatoms independently selected from N, O and S; R is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R is H, alkyl of 1 to 12 carbon atoms optionally substituted, cycloalkyl of 3 to 8 carbon atoms, bicycloalkyl of 5 to 10 carbon atoms or aralkyl optionally substituted; R is OH or -OH; R and R are each independently H or alkyl of 1 to 12 carbon atoms or when optionally taken together with the nitrogen atom to which each is attached form a 3 to 8 membered saturated heterocyclyl ring; R is alkyl of 1 to 12 carbon atoms optionally substituted; or a tautomer or pharmaceutically acceptable salts thereof.

本发明提供式的化合物；其中：R 1 为选自基团和的部分；n为整数1或2；R 2 选自氢、氨基、-NR 6 R 7 、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、具有2到12个碳原子的视情况经取代的炔基、卤素和具有1到4个独立地选自N、O和S的杂原子的视情况经取代的5元到10元杂芳基环；R 3 选自氢、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、乙烯基、具有2到12个碳原子的视情况经取代的炔基和卤素；R 4 为H、具有1到12个碳原子的视情况经取代的烷基、具有3到8个碳原子的环烷基、具有5到10个碳原子的双环烷基或视情况经取代的芳烷基；R 5 为OH或-OH 8 ；R 6 和R 7 各自独立地为H或具有1到12个碳原子的烷基，或当视情况与其所连接的氮原子连接在一起时形成3元到8元饱和杂环基环；R 8 为具有1到12个碳原子的视情况经取代的烷基；或其互变异构体或医药学上可接受的盐。

In those well-formed geometric structures, not only does the scripture express its mystery and the beauty of cutting, but it stands for the symbol of Buddhism. There are numerous works demonstrate this statement, such as "Ark of Dream,""Scriptures,""Pilgrimage of Buddhist Scriptures,""Spiral Scriptures,""Floating,""Pipal,""Big Spiral Scriptures,""Golden Mandala." Besides from placing scripture and leather into fine spatial arrangement, Huang Gang fills the golden background with dark brown dripping technique or paints a large red star. The red star series, which is combined and abstracted from China's interpretation for red, has a particular meaning.

在有规律的几何形式构成画面之中，除了倾心展现经版的刀笔之美、经文的神秘意味，经版始终是菩提灵性的表征符号，而不仅仅是一种简洁的对象，例如《梦之舟》、《佛经》、《朝经之路》、《转经》、《行云流水》、《菩提树》、《大转经》、《金色的曼陀罗》等，进一步地，在空间表现上，在经版或皮革构成的实体空间之外，其非实体空间恰当地运用了书写性和涂绘性的表现主义语言风格，在经版的金黄色域背景上涂绘、滴沥黑褐色，有的则间以大漆涂刷那些红星。

That's when-on the imaginary dome 圆屋顶 of sky surrounding Earth-The two planets share the same right ascension赤经, which is like celestial天上的 longitude.

这一天这两颗行星在虚构的包围地球的天穹上享有同样的赤经，赤经就好比天上的经线。

Effects of dry temperature and dry time on properties of heat cured sand and the relationship with binder composition are as follows:sands bonded by binders that are not modified have high strength when dry temperature is high and dry time is long,but their anti-wettability power is poor . Sands bonded by binders that are modified by B but not modified by M can be dried quickly and sand strength is high but anti-wettability power is also poor. Sands bonded by binders that are modified by M but not modified by B can also be dried quickly to obtain maximum strength,then the strength becomes lower when they are dried continually for more time. and sand strength is high but anti-wettability power is also poor. Sands bonded by binders that are modified by M as well as by B at the same time can be dried quickly to obtain maximum strength at low temperature and short time. But the anti-wettability of sand mold is best when they are dried at high temperature and long time.

烘干温度和烘干时间对热硬砂性能的影响及其与粘结剂改性的关系是：未经改性剂B和改性剂M改性的粘结剂砂，脱水速度较慢，烘干温度越高，时间越长，则硬化强度也越高，但未经改性的粘结剂热硬砂的抗吸湿性较差；经改性剂B而不经改性剂M改性的粘结剂热硬砂，烘干硬化速度较快，强度也高，但在高湿度下的抗吸湿性不好；经改性剂M改性而不经改性剂B改性的粘结剂热硬砂，烘干时强度先随烘干时间升高至最大值后，继续烘干时强度又出现下降；经改性剂B和经改性剂M共同改性的粘结剂热硬砂能在短时间和较低的烘干温度下就可烘干到最高强度，即烘干脱水的速度较快，但试样的抗吸湿性差，若在更高温度和更长时间下烘干，试样的抗吸湿性得到改善，综合考虑烘干强度和抗吸湿性要求，对于φ30×30mm试样，理想的烘干温度是200℃，烘干时间20分钟。

Under the affecting of longitudinal and latitudinal wind stress together, longitudinal wind stress of zero class that is symmetrical to equator has no effects on equations. Nevertheless, longitudinal wind stress of one class that is dissymmetric to equator changes the result and makes longitudinal flow not equal to zero.

在经向风应力和纬向风应力的联合驱动下海洋会有不同的响应，零阶的经向风应力也即对赤道对称的经向风应力没有影响到最后结果，而只有一阶的经向风应力也即对赤道反对称的经向风应力，或者说具有辐合辐散的经向风应力对最后的速度场和位势场造成影响，而且一阶经向速度也不再为零。

But kiwi fruit Gan Suanhan, can enterthe kidney and 胃经, the function allays a fever quenches thirst,therefore two kinds come in handy can the Run lips.

而猕猴桃性甘酸寒，能入肾和胃经，功能解热止渴，所以两种合用能润口唇。

Comprehensive survey "黄帝内经", regardless of is to the psychological disease pathogenesis factor, to the psychological disease diagnosis, preventing and controlling and the mental healing significance, all some many penetrating elaboration, and has formed the certain theory system.

综观《黄帝内经》，无论是对心理疾病的致病因素，还是对心理疾病的诊断、防治和心理治疗的意义，都有许多精辟的论述，并已形成一定的理论体系。

Results: the incidence of postcoital vaginal bleeding was lower in postcoital wemen than that in remenopausal wemen, the stages, the incidences of pelvic lymph nodes metastasis, the results of the pap smear cytology tests and hpv tests were not significantly different in two groups. the incidence of cervical adeocarcinomai was lower in postmenopausal wemen than that in prmenoposal wemen. conclusion: the cervical cancer screening is necessary in postmenopausal wemen and they are helpful for preventing the development of cervical cancer.

结果 绝经组与未绝经组比较，绝经组阴道接触性出血较未绝经组发生率低（p＜0.01），两组临床分期、淋巴结转移率、宫颈涂片及细胞学检查阳性率差异无统计学意义（p＞0.05），绝经组宫颈腺癌发生率占4.2％，未绝经组占28.8%，两组中腺癌发生率差异有统计学意义（p＜0.01 结论绝经后妇女宫颈癌发病期别通常较晚，绝经后宫颈病变筛查是必要的，定期妇科检查、宫颈涂片细胞学检查可帮助绝经后妇女预防宫颈癌。

Skin Flap for Transtibial (Below-the-Knee) Amputation 经胫骨截肢术的皮瓣 Load transfer following transtibial amputation appears to be enhanced when the residual limb has a large osseous surface area coered with a durable soft-tissue enelope composed of a well-cushioned mobile muscle mass and full-thickness skin.

当残肢大的骨表面区域覆盖有缓冲作用好的可移动肌肉团和全厚皮肤组成的耐久软组织包封时，经胫骨截肢术后荷重转移似乎增强了。

Skin Flap for Transtibial (Below-the-Knee) Amputation 经胫骨截肢术的皮瓣 Load transfer following transtibial amputation appears to be enhanced when the residual limb has a large osseous surface area covered with a durable soft-tissue envelope composed of a well-cushioned mobile muscle mass and full-thickness skin.

当残肢大的骨表面区域覆盖有缓冲作用好的可移动肌肉团和全厚皮肤组成的耐久软组织包封时，经胫骨截肢术后荷重转移似乎增强了。

The absorption and distribution of chromium were studied in ryeusing nutrient culture technique and pot experiment.

采用不同浓度K2CrO4(0，0.4，0.8和1.2 mmol/L)的Hoagland营养液处理黑麦幼苗，测定铬在黑麦体内的亚细胞分布、铬化学形态及不同部位的积累。

By analyzing theory foundation of mathematical morphology in the digital image processing, researching morphology arithmetic of the binary Image, discussing two basic forms for the least structure element: dilation and erosion.

通过分析数学形态学在图像中的理论基础，研究二值图像的形态分析算法，探讨最小结构元素的两种基本形态：膨胀和腐蚀；分析了数学形态学复杂算法的基本原理，把数学形态学的部分并行处理理念引入到家实际应用中。