细辛醚

Methods The cardiac myocytes model of myocardial ischemia reperfusion injury was induced with sodium dithionite (Na2S2O4). The primary cultured cardiac myocytes of SD neonatal rats were randomized into six groups: normal group, model control group, high-dose β-asarone (25 μg/mL), middle-dose β-asarone group (12.5 μg/mL), low-dose β-asarone group (6.25 μg/mL) and medium group.

采用连二亚硫酸钠(Na2S2O4)建立心肌细胞MIRI模型，将原代培养的SD大鼠乳鼠心肌细胞分6组：正常对照组、MIRI模型组、β-细辛醚高、中、低剂量组(25， 12.5， 6.25μg/mL)、基质组。

Results The optimum combination was 10μmol/L β-asarone +3μmol/L eugenol, which can decrease the concentration of intracellular Ca(superscript 2+), inhibit the production of NO and increase the survival rate of PC12 cells.

结果β-细辛醚10μmol/L+丁香酚3μmol/L组合能有效减少细胞内Ca(上标 2+)浓度，抑制NO的产生，提高细胞存活率。

Rats in both normal control and epileptic control were ip. saline 0.5 mL, and other groups were ip. phenobarbital sodium 18 mgkg^(-1), acrous gramineus 2.35 gkg^(-1),α-asarone 29 mgkg^(-1), respectively.

正常对照组和致痫对照组均给予生理盐水0.5 mL灌胃，其余各组分别给予苯巴比妥钠18 mgkg^(-1)、石菖蒲2.35 gkg^(-1)、α-细辛醚29 mgkg^(-1)灌胃。

The number of Bcl-2 positive cells in phenobarbital sodium, A. gramineus, and α-asarone groups was more than that of epilepsy control group significantly (P.01). But the number of Bax positive cells was no markedly difference among the each groups.

其中，苯巴比妥钠组、石营蒲组、α-细辛醚组Bcl-2阳性细胞数量增加较致痫对照组显著(P.01)；Bax阳性细胞数量各致痫组之间无显著性差异。

Objective To study the protective effects of volatile oil of Acorus tatarinowii Schott andβ-asarone on cardiovascular system.

目的 研究石菖蒲挥发油、β-细辛醚对心血管的保护作用。

Objective To explore the effect of Acorus gramineus and its active component a-asarone on apoptosis of hippocampal neurons in young rats with epilepsy induced by pentylenetetrazol.

目的 探讨石菖蒲及其有效成分α-细辛醚对戊四氮诱发的幼鼠癫痫发作所激发的海马区神经元凋亡的影响。

The content ofα-asarone decreased after compathility of two medicines,it showed that the adding of RP inhibited dissolution ofα-asarone.

结果发现配伍后α-细辛醚含量降低，表明远志的加入抑制了α-细辛醚的溶出。

And various pharmacodynamical parameters of α-asarone, a main effective constituent of Acrous Gramineus, in the body of rat have also been tested and the result has indicated that α-asarone taken orally can be absorbed quickly and distributed widely.

测定其主要有效成分α-细辛醚在大鼠体内各项药物动力学参数，结果表明：α-细辛醚口服吸收快，在大鼠体内分布广泛。

The main three parts of the present study are: the preformulation study involving screening the proper enhancers for transdermal aborption of α-asarone;Formulation study and developing a drug-in-adhesive transdermal patch of α-asarone using Eudragit E100 as pressure sensive adhesives;The α-asarone reservoir patch was prepared using 1 %HPMC of ethanol solution as medium and EVA membrane for controling the release of drug, and do the research its bioavailability.

主要内容有以下三个方面：药物经皮吸收制剂开发的处方前研究工作；采用Eudragit E100为压敏胶材料，进行了α-细辛醚胶粘剂分散型贴片的研究；以1%的HPMC的醇性溶液为储库介质，以EVA膜为控释膜，进行了α-细辛醚储库型贴片和生物利用度的研究。

The result showed that chromatogram peaks were summated,peak area increased and two new peaks were found.It suggested that the composition dissolution of RP was increased with the addition of RAT,chemical changes may be occurred after compatibility. Established the HPLC analysis method forα-asarone in RAT and researched the content change ofα-asarone after compatibility.

发现配伍后色谱峰具有加和性，峰面积增加，有两个新峰产生，提示石菖蒲能使远志中的化学成分溶出度增加，两药配伍后可能发生了复杂的化学变化；建立石菖蒲中α-细辛醚的HPLC分析方法，研究配伍远志后α-细辛醚的含量变化。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。