细胞迁移素

Thus, Clara cells resemble alveolar type II and bronchiolar ciliated epithelial cells by showing integrin mediated pro-migratory changes to extracellular matrix components that are present in tissues after injury.

Clara细胞与肺泡II型上皮细胞和支气管纤毛上皮细胞类似，其组织损伤后向胞外基质的促迁移改变依赖于整合素的调节。

It could inhibit the adhesion and migration of melanocyte.

对黑素细胞的黏附和迁移却呈现抑制作用。

These results suggest that flow-induced shear stress regulates the expression of β1 integrin, in turn affects the motility of trophoblast cells.

流动剪切力的参与调节了滋养层细胞β1 整合素的表达，从而可影响滋养层细胞的迁移。

Aside from pancreatic enzymes activiation and autodigestive process, recent investigations have established that the upregulation of inflammatory mediator are believed to be the critical steps in the progression of mild pancreatitis to severe pancreatitis. Tumor necrosis factor-, ThyomboxaneA2 ,ProstaglandinsI2 are all important inflammatory mediator. TNF-( is one of cytokines. It is important to the over-production of ICAM-1,VCAM-1, TXA2 andPGI2. The ICAM-1 and VCAM-1 mediate both leukocytes adhesion and migration through the endothelium into tissues to connect with injuried target cells. The TXA2 and PGI2 are the production of arachidonic acid. They are responsible for the tissue ischaemia.

肿瘤坏死因子（Tumor necrosis factor-， TNF-、血栓素A2（ThyomboxaneA2，TXA2），前列环素（ProstaglandinsI2，PGI2）均是炎症反应中重要的炎性介质，其中肿瘤坏死因子-是非常重要的细胞因子之一，它由活化的单核细胞产生，在细胞间黏附分子（Intercellular adhesion molecule-1，ICAM-1）及血管细胞黏附分子(Vascular cell adhesion molecule-1，VCAM-1的表达、血栓素A2及前列环素过量生成方面起着重要的作用，前两者是介导白细胞与内皮细胞黏附，迁移于组织并与受损的靶细胞相结合的主要媒介，是炎症反应中的重要介质，后两者是花生四烯酸的代谢产物，亦是重要的炎性介质，参与构成血液循环障碍。

The forced expression of myogenin could induce NIH3T3 fibroblast to differentiate into myogenesis, it was identified as a pair of bands on SDS-PAGE. The phosphorylated form implies a significant structural change in the myogenin protein, which is expected to affect its function at post-translational level.

强制性表达外源性生肌素可启动NIH3T3成纤维细胞分化，进入成肌过程。pCD1-myog转染后的蛋白印迹带型迁移率发生改变，说明磷酸化导致生肌素蛋白结构的明显变化，并可能在翻译后水平影响其功能。

Angiostatin is an effective suppressing protein to angiogenesis or vasculogenesis by inhibiting proliferation, migration and tube formation in endothelial cells, so it is considered as a sufficient inhibitor of tumor metastasis.

血管生成抑制素是一种新血管生成抑制蛋白，它可以有效抑制内皮细胞的增殖、迁移和管状形态的产生，是肿瘤转移的有效抑制剂。

So, HGF is also named as mitogenic factor、scattering factor、morphogen.

因此，HGF又称促有丝分裂因子、离散因子、细胞形态发生素或促迁移因子。

The capacity of endothelial cells to recognize and migrate in response to the extracellular matrix depends on one or more members of the integrin family of cell adhesion receptors.

血管新生的过程依赖于参与血管生成的细胞因子和细胞粘附的协同作用，整合素是一组细胞表面受体，介导细胞-细胞间、细胞-基质间的相互作用，对内皮细胞的粘附、迁移、增殖起重要作用。

Can reverse JA-induced migration inhibition JA-treated cells also showed significantly higher adhesion to laminin In conclusion these results indicate a novel anti-tumor role of JA via reducing reorganization of cytoskeleton increasing integrin 3 expression and adhesion ability to inhibit tumor cells migration Furthermore immunofluorescence staining of phalloidin/actin indicated that JA-treated cells exhibited cytoskeleton rearrangement and significant decreases in the number and length of filopodia Activity of Rho-family small GTPases was detected by a GST-pull down assay and showed that GTP-loaded Cdc42 and Rac were decreased in JA-treated cells In the future we hope these findings will be helpful to further understand the mechanisms underlying tumor progression in oral cancer and subsequently improve the cancer prevention and treatment

以抗体阻断integrin ？3可以有效使OC2恢复被JA所抑制的迁移能力。细胞贴附实验指出JA能提高OC-2在laminin环境下的贴附能力。当我们进一步以免疫萤光染色观察细胞，发现在JA处理下的OC-2，其外形、细胞骨架和细胞边缘的filopodia的密度和长度明显减少，利用GST-pull down assay侦测到Cdc42-GTP和Rac-GTP的表现量降低。推论爵床素A可能透过刺激口腔癌细胞大量表现integrin ？3，使细胞贴附能力增加或是透过改变细胞骨架来降低细胞迁移能力。希望本研究对於JA所做的抗癌及抗转移效应评估能提供口腔癌治疗在研发上一些帮助。

Objective To inverstigate the roles of urokinase2tye plasminogen activator in the proliferation of cultured outer root sheath cells.

毛囊细胞再生素Follicular cells factor是蛋白酶家族的成员，在体内广泛参与纤溶、排卵、组织修复、细胞迁移等过程。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。