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One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活,ICAM-1表达升高,与被激活的PMN表面表达的LFA-1相结合,"PMN-EC"相互作用加剧,一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍;另一方面粘附的PMN过度吞噬或激活,当白细胞吞噬的颗粒不能被封闭隔离,连同细胞内的酶被释放出来,其中的PMN-elastase能够降解细胞基质中各种成分,水解多种蛋白,加重胰腺的毛细血管内皮细胞和腺泡的损伤;释放的溶酶体酶使组织蛋白水解,产生的不饱和脂肪酸引发脂质过氧化方应,破坏细胞膜的结构和功能;释放的炎性细胞因子,激发其他的免疫细胞的功能,导致进一步的组织损伤和坏死,加重SAP的病理损伤,最终导致休克、脓毒血症及多器官功能障碍等严重后果。

Similarly, there is no definite conclusion about the effect of cellular alkalinization. It is well known that alkaline conditions are cytotoxic, but the mechanisms leading to alkaline-induced cytotoxicity are still unclear.

细胞内的碱化对於细胞的作用同样尚未有一明确的定论,一般而言碱化被认为是对细胞体有害的刺激,但是其促使细胞死亡的机制也尚不明朗。

Results DC activated with DNP modified M3 are able to stimulate effectively T lymphocyte proliferation and the T cells can specially lysis M3 melanoma cells.

结果经 DNP 修饰的 M3细胞激活的 DC ,诱发的 T 细胞增殖能力和对 M3细胞的特异性杀伤效应均明显高于未修饰的 M3细胞组和 DC 组。

Current studies are focusing on free radicals, overload and oscillation of intracellular Ca〓, the changes of intracellular pH and osmotic pressure, activation of endothelial cells and injury induced by neutrophilic granulocyte, cytokines and transcriptional factor NF-KB, etc.

目前的研究主要集中在自由基、细胞内钙超载和钙震荡、细胞内pH和渗透压的变化、内皮细胞的激活、中性粒细胞介导的损伤以及细胞因子和转录因子NF-KB等所引起的损伤。

Many dendritic projections appeared at the adherent cells gradually observed by light microscope; By scaning electron microscope, typical"veiled"DC appeared with abundance of gauffer and the edge of the veil made of graded dendritic projections; all kinds of DC conjected and composed of cluster by the projections. 2. The percentages of CD markers were CD123/54. 5, CD11c/88. 99, CD40/56. 65, CD1a/69. 36, CD86/92. 57, CD80/70.79, CD83/85. 91. 3. The numbers of T cells expressing CD69 has been increased strikly (CD4+CD69+/19. 05%; CD8+CD69+/21. 93%). 4. The augment of percentages of CD3+, CD25+, CD45RO+/CD45RA+, CD4+/CD28and CD8+/CD28- and the decrease of CD28+ and CD45RO-/CD45RA+ in both the CD4+ and the CD8+ T cells could be exemed.

光镜下见贴壁细胞在培养过程中(7天)逐渐长出长短不一树突状突起,细胞形态不一;电镜观察到DC表面呈多层"面纱"覆盖,有大量皱褶,"面纱"边缘有长短不一的不规则的树突状突起,每个突起有多级分枝;AFM见DC细胞的"面纱"状结构是由多级树突状突起相互缠绕形成的,各个DC细胞之间的突起相互连接,构成集落; 2。

The luminescence intensity of suspended immune cells (1×10〓 cells/ml) from peripheral blood, anterior kidney and spleen of grass carp, which were from two groups immunized with being injected Aeromonas hydrophilia and unimmunized respectively, were detected by means of BPCL4 Intelligentized Ultraweak Luminometer, the datum that were dealt with statistics demonstrated that luminescence intensity of the cells from all kinds of immune organs and blood were intensified after the fish were immunized in two weeks and the luminescence intensity from anterior kidney cells was the highest, mitogens had the enhancing effects. Luminol could strengthened luminescence intensity.

把未免疫的和经过嗜水产气单胞菌注射免疫的草鱼外周血、前肾、胸腺和脾脏以及它们的悬浮细胞(密度控制在1×10〓个细胞/ml左右)分别用BPCL4智能化微弱发光测量仪测量各组的发光强度,结果显示:草鱼各类免疫器官与细胞在免疫两周后发光强度增加,肾细胞的发光强度最大;有丝分裂原具有增强作用;化合物鲁米诺能提高发光强度。

Moreover, the article discusses the mechanism by which promotes plant growth in detail by analysing the cell morpho genesis, expansion of cell wall and the cole of cytokeloton in cell elongation.

另外从细胞的形态发生、细胞壁扩展的机制和细胞骨架在细胞伸长中的作用等几个方面对油菜素内酯促进植物生长的细胞及分子生物学机制进行了详尽的论述。

In conclusion, the results indicated that the calpastatin level was modulated by certain growth and differentiation factors and its continuous presence resulted in the inhibition of myoblast fusion. Calpains may play an important role in cytoskeletal reorganization that is requisite for myoblast fusion.

结果表明,细胞内calpastatin的含量是由某些生长与分化因子调控的,calpastatin的连续出现抑制了成肌细胞的融合,说明calpains在成肌细胞融合进程中,对细胞骨架的重组起关键性地作用。

The proliferation was determined by measuring -TdR incorporation in a β-scintillation counter. RESULTS: The in vivo administration of CCK-8 resulted in increase of B7.2 expression, but without any influence on B7.1 expression in peritoneal macrophages. CCK-8 also exhibited increased the -TdR incorporation in CD4(superscript +)T cells.

结果:整体应用CCK-8作用小鼠腹腔巨噬细胞,与对照组相比,CCK-8可上调静息小鼠腹腔巨噬细胞B7.2的表达,而对B7.1的表达则无影响;并且CCK-8使CD4T细胞[3H]-TdR的掺入率升高,即促进其增殖,增强巨噬细胞的协同刺激活性。

The animal model of this method system have, the characteristics of the high fat, high leptin, high Ins, and match with the characteristic of clinical and the pathologic of simple obesity. This studies showed: The acupuncture can obviously reduce the vaule of intaking food and water of the fat rats, and lower the body weight and fat; The acupuncture can urge the diameter, area, physical volume of white fat cell contract, Brown fat tissue of fat rat group surroundings vascular containing large quantity of white fat cell, the acupuncture group was less. this showed: The acupuncture enhanced the white fat cell metabolism, and promotesed the white fat cell to convert to brown fat cell; The frequency of spontaneous electric of nerve cell of pvn of the fat rat is high, the acupuncture counld depress the spontaneous electric of nerve cell of pvn, This showed: the acupuncture can depress the appetite passing to adjust function of pvn nerve; The monoaminergic neurotransmitter of inside of the fat rat brain is disfunction, the acupuncture can rectify this disfunction, and adjust level of 5-HT, and affect appetite, and improve metabolism; The level of leptin and Ins of fat rat increased high, The level of it of acupuncture group decreased, compared with the fat group p.001, This showed: the fat rats have the defeat of leptin and Ins in the body, The acupuncture can lowering this defeat, The level of leptin and Ins of the fat rat in the brain is less than the normal group, The level of leptin of the acupuncture group is high than the fat group, This showed: the acupuncture can increase the transportation of leptin from blood to brain.

本方法所制肥胖大鼠模型具有高体重、高脂、高leptin和高Ins血症的特点,符合人类单纯性肥胖病的临床和病理特征;实验研究显示:针灸能明显减少肥胖大鼠的摄水、摄食量及降低其体重、体脂;针灸能促使白色脂肪细胞直径、面积、体积缩小,减少肥胖大鼠棕色脂肪组织血管周围白色脂肪细胞数量,显示:针灸增强了白色脂肪细胞的代谢,促进了白色脂肪细胞向棕色脂肪细胞的转化:肥胖大鼠PVN神经细胞自发放电频率增加,脑内单胺递质紊乱,针灸通过抑制PVN亢奋的自发放电,调整5-HT水平,达到影响食欲,改善代谢的作用;肥胖大鼠血中leptin及Ins水平增高,与正常组大鼠比有明显差异,提示大鼠体内存在leptin及Ins抵抗,针灸后肥胖大鼠随着体重体脂的下降,血中leptin、Ins水平降低,与肥胖组比均有显著性差异,而针灸后大鼠脑内leptin增加,与肥胖组比P.05,提示:针灸具有改善leptin、Ins抵抗及增加leptin脑内转运的作用。

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推荐网络例句

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了,排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意,我建议我们在价格上大家各让一半。

After an hour and no pup, look for continued contractions and arching of the back with no pup as a sign of trouble.

一个小时后,并没有任何的PUP ,寻找继续收缩和拱的背面没有任何的PUP作为一个注册的麻烦。