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Objectives: To study the relationship between matrix metalloproteinases and their inhibitors and the invasion and metastasis of human glioma, as well as the relationship between the expression of MMP-2 and TIMP-2 in human primary and recrudescent glioma and the grade of malignancy.

目的:探讨基质金属蛋白酶类与胶质细胞瘤浸润性生长之间的关系及其在胶质瘤复发中的作用,以及基质金属蛋白酶及其抑制因子(MMP-2、TIMP-2)的阳性表达与胶质细胞瘤病理分级及预后的关系。

During the surgery, the lesion was found to be a solid tumor. A surgical wedge biopsy was done and purulent dark yellow fluid was drained from the center of the mass. Histologically, there was a solid pattern of rhabdoid and anaplastic round or oval cells haphazardly arranged with poor differentiation. Immunohistochemical staining was positive for vimentin, a mesenchymal marker; the reticulin staining was consistent with carcinoma.

我们实施了手术切片及肿瘤中心脓状物引流,病理组织学上,我们发现了不规则或未分化的横纹状、圆形及椭圆形细胞;免疫组织染色上,细胞广泛的对非上皮标记vimentin呈阳性反应、且其reticulin染色呈现出腺癌的形式;肉瘤及腺癌的特色皆可在切片中看到,所以我们的诊断是类肉瘤性线癌。

After sciatic nerve lesion 3 days, Schwann cells and other non-neuronal elements, begin to proliferate and express a great deal of neurotrophic factors incloding NT3, showing that NT3 may be transported retrogradely to neuronal soma, resulting in strong immunoreactivity.

损伤后3天,以雪旺细胞为主的非神经细胞开始大量增殖,雪旺细胞表达大量神经营养因子包括NT3,并逆向转运到达运动神经元胞体,这也导致免疫反应性的增强。

Therefore, collagen metabolism is the center of the extracellular matrix remodeling in intracranial saccular aneurysms, while the essence of the remodeling process is a kind of autoimmunological and inflammatory reaction.

因此,胶原代谢是囊性动脉瘤细胞外基质重塑的核心内容,而重塑过程的实质是一种以细胞免疫为主的免疫炎性反应。

Low reaction of fetus to inflammation, different extracellular matrix, component of collagen fiber and cell factors may take part in scarless healing process. Regulation of gene expression may play an important role in the process. But the concrete mechanism of scarless healing is not clear yet and still needs more researches and elucidations.

胎儿对炎症的低反应性、胎儿不同的细胞外基质、胶原纤维的成分、细胞因子可能也参与了无瘢痕愈合过程、基因表达调控在其过程中可能也起重要作用,但无瘢痕愈合的具体机制还不明了,有待进一步研究阐明。

The embryogenic cell first divided into multicellular proembryos,then globular embryoid,pearshaped embryoid,long embryoid,scutiform embryoid and mature embryoid.

胚性细胞继续分裂形成多细胞原胚,经球形胚、梨形胚、长形胚、子叶分化期到成熟胚,其发生的胚状体与单子叶合子胚形成具有相似的过程。

The mechanical strength, solubleness and the capability to induce ossification of the materials could be improved obviously when strontium was added, which were formed of hydroxyapatite and tricalcium phosphate.

试验研究证实锶盐具有抗骨吸收和增加骨形成的作用,锶盐可以抑制破骨细胞的活性,促进成骨细胞的活性,促进骨盐的沉积;其与羟基磷灰石和磷酸三钙等复合后,其机械强度、溶解性及诱导成骨能力等特性明显得到改善;锶盐口服有治疗骨质疏松症的作用。

Two pathways may belong to the same functional system, though they have some architectural difference. It has been disscussed that some neural structures in the visceral afferent pathway may have some relation to the somesthetic afferent.

在梭形细胞的树突上见到较多的对称性突触,突触前末梢含有多形性囊泡;在卵圆形细胞的远核区和树突上,常见到含圆形囊泡的末梢,与胞体和树突形成不对称性突触。

Objective: To investigate the possible role of spasmolytic polypeptide and extracellular signal regulated protein kinase in the pathogenesis of helicobacter pylori relaed gastritis.

目的:探讨幽门螺杆菌在Hp相关性胃炎的发病机制中对胃黏膜上皮细胞解痉多肽以及细胞外信息相关蛋白激酶表达的影响。方法:检测68例浅表性胃炎患者的活检组织标本。

So it can be essential momitoringindex of colon carcinoma and its tumor specificness is apply by manygene therapy of tumor. Transcriptional regulatory element of CEAcontains enhancer element and promotor in the 5th flanking region whichcan control expression of objective gene in positive cancer tissue of CEA. Objectives: To explore the joint promoter with high activity,consisting CEA promotor and CMV enhanser.

目的:本课题探讨由CEA启动子、CMV增强子组成的高活性嵌合启动子,通过融合启动子的调控提高融合自杀基因yCDglyTK在靶细胞表达的特异性;并以无毒副作用生物相容性好的磷酸钙纳米为载体,将该自杀基因靶向导入结肠癌细胞中,以达到提高基因治疗靶向性及安全性的目的。

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