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However, this approach conferred the resistance to not only myelopoietic cells but also tumor cells that have invaded or metastasized into bone marrow or circulating blood for nonspecific expression of the exogenous genes.

详细骨髓造血细胞中导入耐药耐辐射基因是克服放化疗对造血系统抑制作用的有效手段,但外源基因的非特异性表达也增加了残存在血液或者侵犯至骨髓中的肿瘤细胞耐受性。

Electron microscope showed immature myogenous cell.

电子显微镜示培养细胞为幼稚肌源性细胞。

Methods The expression of CD87 was detected with flow cytometry in 54 AML patients and 20 acute lymphoblastic leukemia patients. The expressionsa of CD87 on U 937, HL-60 and K562 cells were also studied with FCM and reverse transcription-polymerase chain reaction during differentiation induced by phorbol myristate acetate in vitro.

应用流式细胞术检测了54例急性髓性白血病及20例急性淋巴细胞白血病患儿CD87的表达,还用FCM及逆转录-聚合酶链反应法检测了U937、HL-60、K562细胞在氟波酯作用下诱导分化过程中CD87表达的改变。

Its biological characteristic express two ways: increase wall of micrangium"s permeability and conjugate vascular endothelial cell"s specificreceptor, anxo-act vascular endothelial cell cleavage and proliferation, so lead to formate neogenetic vascular.

VEGF的生物学特性主要表现在两方面:增加微血管的通透性和特异性的与血管内皮细胞受体结合,促进血管内皮细胞的分裂和增殖,进而导致新生血管的生成。

BMSCs can be induced into neural stem cells and further neural stem cells derived from bone marrow can differentiate into neural cells and neuroglial cells.

骨髓基质细胞能在体外诱导分化出神经干细胞,且骨髓源性神经干细胞可进一步定向分化为神经细胞及神经胶质细胞。

Moutains of evidences from laboratary and clinical data show that gene abnormality is the major etiological factor of over 40% patients affected with epilepsy.There were also 6 epilepsy genes been cloned successfully, and mutations of over 1000 genes maybe related to epilepsy. These abnormal genes influence many aspects from molecular level to the neuronal plasticity, such as the development of brain,neuronic degeneration, remodeling of neural circuits, energy metabolism, ion channel and so on.These factors would at last affect the formation of epilepsy focus, propagations of epileptic potentials, vulnerability of epilepsy cells.

大量的实验和临床资料提示基因异常是40%以上癫痫患者的病因,有6种常见全身癫痫的基因已被成功克隆,1000种以上的基因突变可能与癫痫的发作有关,这些表达异常的基因分布在脑发育、神经元变性及神经环路重组、能量代谢、离子通道等多个环节,从分子、细胞、神经元可塑性等多个方面影响着癫痫灶的形成、痫性放电的扩布及癫痫细胞的损伤,构成了癫痫的基因机制。

PPO gene was not detected in the multiple myelome、 malignant fibrous histiocytoma 、malignant lymphoma、malignant neurosarcoma、solitary plasmacytoma of bone、primitive neuroectodermal tumors、lipoma、 osteosarcoma and sarcoenchondroma.

PPO基因在多发性骨髓瘤、恶性纤维组织细胞瘤、恶性淋巴瘤、恶性神经肉瘤、孤立性浆细胞肉瘤、原始神经外胚瘤、脂肪瘤、骨及软骨肉瘤等肿瘤中没有表达。在骨巨细胞瘤中有微弱表达。

Whether there are differences in the expression of the principal cytokines and chemokines relevant to eosinophilic and neutrophilic inflammation in the airway tissues of severe compared to moderate asthmatics has not been determined.

然而在中度和重度哮喘气道内组织,与嗜酸细胞和中性粒细胞性炎症相关的主要细胞因子和趋化因子的表达是否存在差异现在还不明确。

Many years ago, it have been noticed that, not all injurise of heart cell were directly proportional to the inflammatary reaction, and this kind of noninflammatory damage may be apoptosis. Kawano has verified first time in 1994 that, the onset and development of VMC accompanied the apoptosis, and the apoptosis probably are significant mechanism from VMC to the dilated cardiomyopathy.

早有人注意到,VMC时心肌损伤并不都与炎症反应成正比,其存在的非炎症性损伤很可能是细胞凋亡。1994年Kawano等首次证实心肌炎伴有心肌细胞凋亡,后者可能是心肌炎发展成扩张型心肌病的重要机制。

AbstractTrehalose, as a nonreducing disaccharide, plays a role in protecting the cytoactivity when the cells is freezing, drying or lyophilization.

海藻糖作为一种稳定的非还原性双糖,在细胞冷冻、干燥、冻干过程中对细胞活性有着良好的保护作用并已广

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