细胞性

Domenstic and abroad academicians have disclosed the influence mechanism of these factors from different aspects, including the gene polymorphism and gene mutation in genetics, which are a susceptible factor for cardiovascular complication in type 2 diabetes patients; the dysfunction of endotheliocyte, the metabolic disorder of lipid, and dysfunction of vascular smooth muscle, which can lead to the formation of arteriosclerosis;the formation of immune complex,which can also accelerate the destruction of artery paries;the sctivation of protein kinase C and the dysfunction of platelet, which may ultimately result in the formation of thrombus and influence the function of cadiac muscle cells.

其中主要包括：遗传学方面的基因多态性和基因突变，二者均是2型糖尿病合并心血管疾病的一个易感因素，内皮细胞功能障碍、脂质代谢异常及血管平滑肌细胞功能异常均可导致动脉粥样硬化的形成；免疫复合物的形成可加速动脉壁的破坏；蛋白激酶C的激活及血小板功能受损最终导致血栓形成并影响心肌细胞的功能。

RESULTS: Levels of insulin, FFA, GOT and GPT in serum were significantly increased in model group; activities of T-SOD and GSH-Px in liver tissue and ISI were notably decreased, and content of lipid perhydride MDA was increased. HE staining revealed that there was hepatic cellular swelling in hepatic lobules, inequality of size of lipid droplets in periplast, nucleus on one side, narrowed sinus hepaticus and inflammatory cell infiltration in hepatic lobules and portal area.

结果： 模型组大鼠血清胰岛素、FFA、GOT和GPT水平明显升高，肝组织中T-SOD和GSH-Px活力和ISI明显下降，脂质过氧化物MDA含量显著增加， HE染色示肝小叶中大部分肝细胞肿胀，胞质中出现大小不等的脂滴空泡，以大泡性脂肪滴为主，核居边，细胞界限不清，肝窦狭窄，且存在小叶内及门管区炎症细胞浸润。

These discoveries not only let us to know the function of the novel protein CBAP but also shed light on the pleiotropism of receptor βc which transduce both positive and negative signaling upon presence and absence of cytokine-a new study field of the cytokine receptors.

这样的发现，仅让我们解一新颖蛋白的功能，开启细胞受体研究一个新的方向-细胞受体的多效性，在有无细胞激素的激下，传递正面及负面的讯息。

Although the primary human hepatocytes would be ideal for bioartificial livers, the shortage of hepatocytes and the difficulty to increase the doubling time of human hepatocytes in vitro limit the clinical application.

肝细胞是生物人工肝支持系统的核心部分，从生物工程学角度讲，理想的用于生物人工肝的肝细胞要人源性、表型正常，容易获得和培养，能在体外迅速生长增殖至高密度，保持良好的分化状态，具有成熟肝细胞的所有生物代谢功能。

After 24 hours of incubation,the cells became bigger,irregular and typical DCs with pseudopodium. The floating cells were separately induced to CIK cells and LAK cells. CIK cells proliferated rapidly and became a lot of large growth-colonies.

悬浮的细胞分别用于诱导生成CIK和LAK细胞，3天后CIK细胞生长迅速，出现大量的生长集落，体积明显变大呈多形性。

Microglia, one of the main immune cells in central nerve system, was activated in inflammation with morphological changes from resting ramified to staffed and amoeboid cells.

作为脑内的主要免疫细胞，小胶质细胞在中枢神经系统炎症过程中被过度激活，表达或释放细胞因子和炎症介质，是早老性痴呆发生发展的重要因素。

Statistical significance can not be found between 24hours and 48 hours.. Under an inverted microscope , we can observed the cells adherent, fullness, polygon in control group, the cells amout sparse, suspended, quasi-round, and no refractional nature in experiment groups, the highter the concentration is, the greater themorphological change of cells will become.

形态学分析，在倒置显微镜下可见，经药物作用后MCF-7细胞数目减少，细胞形态由原来的贴壁良好、饱满、多角形、梭形变为类圆形、悬浮、颜色变暗、无折光性，且随药物浓度的增加细胞形态变化越大。2。

In previous studies, Cyclooxygenase-2(COX-2) is believed to be linked with inflammations and tumors. But in recent reports, COX-2 is found to play important roles in osteoblastic mechanotransduction and in bone remodification and resorptions in some ways. It was found that mechanical stretches, such as hydrostatic forces and pulsating fluid flow, could increase the expressions of COX-2 mRNA and then prostaglandins, and activate many signal pathways in osteoblasts.

环氧合酶-2(cyclooxygenase-2，COX-2)以往被认为与炎症、肿瘤等有密切关系，近年研究发现它在骨骼重建、骨质吸收以及成骨细胞力学信号转导中发挥着重要作用，主要表现为机械牵拉、流体力、节律性液体流(pulsating fluid flow，PFF)等机械刺激均能引起成骨细胞COX-2高水平表达，进而引起前列腺素(prostaglandins，PGs)量的增加，激活成骨细胞内多条信号传导通路。

Inhibition of CK2 phosphorylation events result in dramatic sensitization of tumor cells to TRAIL-induced apoptosis but not normal cells.

当抑制CK2的活性，可以使肿瘤细胞对TRAIL诱发的细胞凋亡产生感受性，但对正常的细胞没有影响。

In recent years, by using sex chromosome or cell surface antigen as a marker, the characteristics of proliferation and differentiation of spleen colony-forming cells have been studied systematically.

近年来，许多学者采用天然的性染色体或是细胞的特异表面标志作为细胞遗传标志深入、系统地研究了脾结节生成细胞（spleen colony-forming cell，CFC-S）的增殖与分化性能。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。