细胞外的

When a strong and slowly degrading scaffold is used, the starting position of alular tissue engineering is a stronger ale and seeded cells are allowed more time to create a strong extracellular matrix.

当使用一个强壮的降解缓慢的支架时，瓣膜组织工程的起始点是一个更加强壮的瓣膜，种植的细胞有更多的时间创造强壮的细胞外基质。

A clear cause-and-effect relationship between excessive myocardial MMP-1 activity, increased mysial collagen degradation, and progression to systolic HF has been shown experimentally through the use of transgenic models and the use of pharmacological MMP activators.53,54 In addition, experimental evidence has been provided showing that following chronic neurohormonal activation, increased synthesis and release of MMPs into the local extracellular matrix of the cardiomyocyte occurs,55 which in turn could contribute to endomysial and perimysial collagen degradation and disruption.

一个明显的因果过多的心肌MMP-1关系活动， mysial增加胶原蛋白的降解和进展收缩性心力衰竭已被证明试验，通过使用转基因模型和使用的MMP药理作用此外，activators.53，54实验证据下面被提供显示慢性神经激活时，增加的MMPs合成和释放到当地的细胞外基质的心肌细胞发生，55反过来有助于人肌内膜和 perimysial胶原退化和破坏。

This review focuses on the development and means of the modification of polymeric gene vectors making them have multifunction, i.e. the ability to maintain stability outside of cell, the ability of cell entrance, endosome escape, and the ability of nuclear membrane traversing. The main challenges remain and the future direction of polymeric vectors research are discussed.

本文在分析基因治疗过程的基础上，详述了基因载体应具有的4种基本功能－在细胞外保持稳定的功能、进入细胞的功能、逃离溶酶体的功能和进入细胞核的功能，并详细介绍了有关基因载体功能化修饰的方法和目前国际上的进展情况，总结了高聚物载体目前存在的主要问题及未来的发展方向。

The ultimate result of chronic HC injury is the accumulation of extracellular matrix with high density type I collagen within the subendothelial space of Disse, culminating in cirrhosis with hepatocellular dysfunction.

慢性HC损伤的最后的结果是在内皮下间隙高密度的1型胶原的细胞外基质堆积，最后为肝细胞的功能障碍、肝硬化。

As a unique receptor for HGF, The expression of c-met is inducible, transcriptionally regulated by a wide variety of cytokines as well as extracellular environmental cues, c-met is expressed in kidney, mainly in renal tubular epithelial cell.

作为HGF现已知的唯一的受体，c-met是一个可诱导基因，可以应答许多的细胞外信号包括细胞因子，生长因子及环境因素的影响。

AGEs is not only the products of diabetes, but also act as one of medium, can induce extensive abnormal reaction in cells and tissue such as unreasonable expression of growth factor, accumulation of extracellular matrix, regulation dysfunction of blood vessel, etc.

AGEs不仅仅是糖尿病的并发产物，还可能充当了一种介质作用，在细胞和组织上启动广泛不正常的反应如生长因子不适当地表达、细胞外基质的积聚、血管调节功能障碍以及死亡通道的启动。

To explore the reciprocal effects of host-tumor interaction, we developed a system to assess the gene expression patterns and the diversity of gene expression of ERK and PI3K pathway in CAOV3 human ovarian cancer cells and primary carcinoma-associated fibroblasts cocultured with each other for 48 hours with RT-PCR.

方法1。采用逆转录聚合酶链反应的方法分别检测交互作用48小时后的卵巢癌相关成纤维细胞与卵巢癌细胞中基因表达的改变，CAFs及CAOV3细胞外信号调节激酶通路的ERK，PI3K基因表达的变化；2。

After autologous transplantation of sciatic nerve segments into the retinae of adult golden hamsters for 1-4 months, anterograde and retrograde labelling with horseradish peroxidase demonstrated that ganglion cell axons have regrown into the peripheral nerve graft for a distance up to 2 cm.

移植后的视网膜标记神经元细胞体面积分布直方图表明：具有再生纤维的神经元胞体面积范围除包括正常大小的神经节细胞外，还包括相当多的胞体增大的神经元。

The results showed that with increase of temperature and ext

结果表明：随着温度的上升和细胞外糖浓度的增加，红细胞的糖吸收率也随之上升，细胞内的海藻糖和葡萄糖浓度分别可以达到30 mmol/L和40 mmol/L以上。

Fibronectin is a very important biological molecule in collagen glucoprotein that plays a number of important roles in the extracellular matrix. It has roles in structural support and signaling cues for cell survival, migration, differentiation, gene expression, growth factor signaling, cell contractility, epithelial tissue repair, alignment regularization and organism immunoregulation.

纤维连接蛋白(fibronectin，FN)是一种具有重要生物学活性的非胶原糖蛋白，是细胞外基质(extracellular matrix，ECM)的重要组成部分，参与机体的细胞连接黏附、增殖分化、信号传导、基因表达、收缩调节、上皮组织修复、排列规则化以及机体免疫调控等重要的生理功能。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。