细胞外的

Recent data indicate that internuclear transcription factors are associated with the intracellular regulatory pathways that convert extracellular physical or mechanical stimuli into a coordinated cellular response.

近年的研究表明，一些核内转录因子也参与了细胞内调控途径，将细胞外物理或机械刺激转化为协调的细胞反应。

The essential events of the process are detachment, intravasation, circulation, arrest, extravasation, angiogenesis and proliferation, which come down to interactions of neoplastic cells with host cells and extracellular matrix -governed by adhesion, migration, invasion, proteaselysis, and the complicated signal transduction.

而所有步骤均可归结为癌细胞与宿主细胞及细胞外基质(Extracellular Matrix，ECM)之间的相互作用——粘附、浸润、移动、蛋白酶分泌以及复杂的信号转导过程，基于细胞信息传递和调控在细胞生命活动中处于主导地位，癌细胞信号转导系统的作用及相关机制对于揭示肿瘤转移的本质，探索新的抗肿瘤转移途径具有十分重要的作用。

PIKA adjuvant may directly enhance immune responses via the induction of cytokine secretion, activation and proliferation of B and NK cells.

PIKA佐剂体内外直接通过诱导细胞因子的产生，B细胞和NK细胞的活化和增殖，而促进免疫应答反应。

It were found by comprehensive analysis, the precisive diagnosis rates of the markers from bronchoalveolar lavage fluid were much higher than that from blood, and the markers from alveolar macrophage were much higher than that from broncholaveolar lavage fluid. The precisive diagnosis rates of fibronectin secreted by alveolar macrophage, and fibronectin secreted by alveolar macrophage inhibited by cort and inhibitory rate were 96. 2%, 92. 3%, and 92. 3%, with the diagnosis markers of higher sensibitity and specificity.

综合分析发现，支气管肺灌洗液中指标的正确诊断率高于外周血，而肺泡巨噬细胞中诊断指标又优于支气管肺灌洗液，其中肺泡巨噬细胞产生的纤维结合蛋白、皮质激素抑制肺泡巨噬细胞产生纤维结合蛋白和纤维结合蛋白抑制率均为敏感性和特异性较高的诊断指标，其正确诊断率分别为96.2%、92.3%和92.3%。

FN and LN (the non-collagenous index) out of ECM were measured by immuno-histochemistry mean, and the accumulation of ECM was measured by typeⅠand Ⅲ collagen ,α-SMA was chosen as a symbol of the activated reposit fat cell. TGF-β〓 was chosen as a symbol of the cellular factor made the reposit fat cell activated. We observed the mechanism of 286 through the variety of the upper indexes during the experiment.

用免疫组化方法测评肝细胞外基质中的非胶原指标FN、LN，胶原指标Ⅰ、Ⅲ型胶原等在实验过程中的变化作为判定ECM沉积增多的事实指标；用a-平滑肌肌动蛋白作为贮脂细胞被激活的标志物指标；用转化生长因子-β〓作为激活贮脂细胞的细胞因子指标；通过观测上述指标在实验中的变化，来探讨"268方"的作用机理。

FN and LN(the non-collagenous index) out of ECM were measured by immuno-histochemistry mean, and the accumulation of ECM was measured by type I amd III coHagen, a -SMA was chosen as a symbol ef .the activated reposit fat cell.TGF- P1 was chosen as a symbol of th ieccellular factor made the reposit fat cell activated.We observed the mi sclnanism of 286 through the variety of the upper indexes during the experiment.

用免疫组化方法测评肝细胞外基质中的非胶原指标FN、LN，胶原指标Ⅰ、Ⅲ型胶原等在实验过程中的变化作为判定ECM沉积增多的事实指标；用a-平滑肌肌动蛋白作为贮脂细胞被激活的标志物指标；用转化生长因子-β_1(TGF-β_1)作为激活贮脂细胞的细胞因子指标；通过观测上述指标在实验中的变化，来探讨"268方"的作用机理。

The other cancers with shorter follow up had three years overall and event free survival as follow: 75% and 62% for Medulloblastoma, 74% and 67% for Non-Hodgkin Lymphoma, 100% and 91% for extracranial Germ Cell Tumour, 30% and 20% for advanced neuroblastoma, 68% and 52% for Ewing's Sarcoma, 87% and 79% for Wilms' Tumour, 82% and 80% for Osteosarcoma, 56% and 45% for Rhabdomyosarcoma, and 60% and 50% for Hepatoblastoma respectively.

其他癌症经三年的短期随访，总存活率及无并发症存活率分别是：成神经管细胞瘤为 75%及 62%；非何杰金氏淋巴瘤为 74%及 67%；颅外的胚细胞瘤为 100%及 91%；已播散成神经细胞瘤为 30%及 20%；尤因氏肉瘤为 68%及 52%；威尔姆斯氏瘤为 87%及 79%；骨肉瘤为 82%及80%；横纹肌肉瘤为 56%及 45%；肝母细胞瘤为 60%及 50%。

Virus hasn't cell construction. A lot of simple virus is only made of nucleus acid and protein tegument, so we can regard it as nucleoprotein. A type of virus pill usual has a kind of nucleus acid. After virus infect sensitive host cell, the nucleus acid of virus will enter cell and produce its descendant and new protein by reproduction and expression. Then, the new synthetic virus is made up of descendant that release form cell by regular way. This specific way of reproduction of virus called reproduction.

病毒不具有细胞结构，一些简单的病毒又由核酸和蛋白质构成，故可把它们视为核酸蛋白分子，一种病毒的毒粒内通常只含有一种核酸，病毒感染敏感宿主细胞后，病毒核酸进入细胞，通过其复制与表达产生子代病毒基因组和新的蛋白质，然后由这些新合成的病毒组分装配成子代毒粒，并以一定的方式释放到细胞外，病毒的这种特殊繁殖方式称为复制。

Through upregulating the production of MMPs in deciduas and chorionic villi, the upregulation of the expression of EMMPRIN in syncytiotrophoblast and cytotrophoblast column of the villi in the threatened abortion can degenerate deciduas and denudates embryo.

发生先兆流产时合体滋养细胞、细胞滋养层柱所表达的EMMPRIN增强可能通过上调绒毛及蜕膜组织中基质金属蛋白酶的水平，降解细胞外基质，使绒毛剥离、蜕膜组织剥脱。

For a start, via modified Boyden chamber invasion assay, we found that twenty-six Chinese medicinal herbs can suppress A549 cell invasion. In this twenty-six Chinese medicinal herbs there are six Chinese medicinal herbs without toxicity, including Davallia mariesii Moore, Phyllanthus urinaria, Prunella vulgaris, Selaginella tamariscina, Viola yedoensis and Terminalia catappa. Based on that tumor metastasis are accompanied with proteolytic degradation of the extracellular matrix and changed cell motility.

首先藉由modified Boyden chamber invasion assay，发现有26种中药具有抑制A549侵入的能力，其中有骨碎补、叶下珠、夏枯草、卷柏、紫花地丁、榄仁树的叶等6种中药不具有细胞毒性，而当癌细胞转移时常常会伴随著细胞外基质的分解及细胞移动能力的改变，在gelatin zymography与casein zymography assay中也发现到它们可以抑制A549人类肺癌细胞的MMP-2及u-PA的表现。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。