细胞基质的

A series of enzymes involved in the process of tumor cells and endothelial cells's migration across basement membrane and extracellular matrix.

肿瘤细胞和内皮细胞穿过基底膜和细胞外基质的迁移过程需要一系列蛋白水解酶的参与。

Thus, Clara cells resemble alveolar type II and bronchiolar ciliated epithelial cells by showing integrin mediated pro-migratory changes to extracellular matrix components that are present in tissues after injury.

Clara细胞与肺泡II型上皮细胞和支气管纤毛上皮细胞类似，其组织损伤后向胞外基质的促迁移改变依赖于整合素的调节。

For a start, via modified Boyden chamber invasion assay, we found that twenty-six Chinese medicinal herbs can suppress A549 cell invasion. In this twenty-six Chinese medicinal herbs there are six Chinese medicinal herbs without toxicity, including Davallia mariesii Moore, Phyllanthus urinaria, Prunella vulgaris, Selaginella tamariscina, Viola yedoensis and Terminalia catappa. Based on that tumor metastasis are accompanied with proteolytic degradation of the extracellular matrix and changed cell motility.

首先藉由modified Boyden chamber invasion assay，发现有26种中药具有抑制A549侵入的能力，其中有骨碎补、叶下珠、夏枯草、卷柏、紫花地丁、榄仁树的叶等6种中药不具有细胞毒性，而当癌细胞转移时常常会伴随著细胞外基质的分解及细胞移动能力的改变，在gelatin zymography与casein zymography assay中也发现到它们可以抑制A549人类肺癌细胞的MMP-2及u-PA的表现。

Multiple studies have confirmed that the apoptotic process of GCs is not only related to apoptotic genes, but triggered by cytokines related to reproduction and Caspases family. Cell adhesion and extra cellular matrix in follicles also play an important intraovarian role. Importantly, the reproductive hormones have strongly related to control ovarian GCs apoptosis.

现已证实，颗粒细胞凋亡不仅与凋亡相关基因有关，而且受许多细胞因子及Caspases家族的调控，也受细胞连接及细胞外基质的影响，更重要的是受到生殖激素首要地网络化控制。

The extension of mixture description to the chondrocytes and the surrounding pericellular matrix in the literature has also provided new insights in the physical regulatory mechanisms that influence cell behaviors in situ.

文献中混合相理论用于软骨细胞以及周围细胞外基质的推广也为体内细胞行为物理调节机制的研究提供了新的思路。

The therapeutic mechanism of the method of nourishing qi, activating blood, dispersing phlegm and promoting the collaterals was supposed as that it intervened the airway remodeling and alleviated the progress of airflow obstruction of COPD by suppressing the chemo taxis of cytokines, regulating the proliferation of fibroblast cell and smooth muscle cell and preventing the proliferation and plerosis of extracellular matrix.

推测益气活血化痰通络法防治COPD的机制可能为：通过抑制炎症细胞的趋化、影响细胞因子的活性、调节成纤维细胞和平滑肌细胞的增殖、阻止细胞外基质的增生修复，从而达到干预COPD患者气道结构重塑，减缓COPD气流受限进展的作用。

We have researched distribution of TGF β and its receptor in various age group and discs of various degeneration grade, found that positive ratio of TGF β and its receptor is higher in below 40 year old group and discs of MRI Ⅰ and Ⅱ grade, mainly occur in fibrous cartilagous cells of fibrous annulus and nucleus pulpous; In group of 40-60 years old and grade Ⅱ and Ⅲ discs, TGF β decreased and TGF β R decreased not as much as TGF β; In above 60 years old group, TGF β and its receptor almost disappear.

生长因子包括TGF-β对细胞功能有重要调节作用，它是一种相对分子质量为2.5×10〓的二聚体多肽，几乎参与了哺乳动物所有细胞的病理，生理过程，尤其是在细胞外基质的产生及调控方面意义重大，且TGF-β已被公认为是与胶原代谢关系最密切的细胞因子。胡有谷、陈宏等，应用杂交技术检测了TGF-β对椎间盘Ⅰ、Ⅲ型胶原MRA的调节作用。

Objective: To explore the mechanisms resulting in the recurrence of urethral scar which make urethral strictures difficult to be cured, a series experiments were conducted to find potential effective factors involved in urethral scar formation and degradation, including the studies of extracellular matrix component of urethral stricture scar, the characteristics of urethral scar fibroblast, and the effects of urine on urethral fibroblast in vitro, as well as the studies to compare the difference of collagenase activity, type Ⅰ collagen and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the tissues and cultured fibroblasts from normal urethra and strictured urethra respectively, and the studies to investigate the effect of antisense TIMP-1 oligodeoxyonucleotide on cell proliferation and collagenase activity of urethral scar fibroblast.

中文题名尿道瘢痕基础研究副题名胶原酶活性，TIMP-1的表达及其反义基因治疗外文题名 Experimental study on urethral scar-activity of collagenase，expression of TIMP-1，and antisense TIMP-1 gene transfection of urethral scar fibroblast 论文作者黄翔导师杨宇如教授学科专业外科学研究领域\研究方向学位级别博士学位授予单位四川大学学位授予日期2002 论文页码总数104页关键词尿道手术瘢痕胶原酶成纤维细胞尿道瘢痕馆藏号BSLW /2003 /R699 /12 目的：研究尿道瘢痕的细胞外基质的组成，尿道瘢痕成纤维细胞的生物学特性以及尿液对其生长的影响；比较胶原酶活性，金属蛋白酶组织抑制因子-1（TIMP-1）以及Ⅰ型胶原含量在尿道瘢痕和正常尿道组织及体外培养的成纤维细胞中的差异；研究反义TIMP-1寡核苷酸对尿道瘢痕成纤维细胞增殖以及胶原酶活性的影响。

Results suggested that Terminalia catappa leaves have no effect on cell viability of SCC-4 cells. The modified Boyden chamber assays revealed that a treatment of Terminalia catappa leaves significantly inhibited the cell motility/invasion capacities of SCC-4 cells.

在本实验中，利用 50%酒精萃取的榄仁树的叶之萃取物处理 SCC-4 细胞株，并利用 MTT assays 分析方法显示榄仁树的叶萃取物并不会影响 SCC-4 细胞的存活率，而当癌细胞转移时常常会伴随著细胞外基质的分解及细胞移动能力的改变，接著我们利用 modified Boyden chamber assay 发现榄仁树的叶萃取物具有抑制 SCC-4 细胞的移动与侵袭能力。

Recent evidence indicates, however, that the hardness of hard wheat comes from greater continuity of the protein matrix within the cells and the tighter bonding of starch granules to this matrix.

然而最近有迹象表明，硬质小麦的硬性是由于细胞内部蛋白质基质的连续程度较大和淀粉该基质的结合较牢而产生的。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失