细胞基质的

One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活，ICAM-1表达升高，与被激活的PMN表面表达的LFA-1相结合，"PMN-EC"相互作用加剧，一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍；另一方面粘附的PMN过度吞噬或激活，当白细胞吞噬的颗粒不能被封闭隔离，连同细胞内的酶被释放出来，其中的PMN-elastase能够降解细胞基质中各种成分，水解多种蛋白，加重胰腺的毛细血管内皮细胞和腺泡的损伤；释放的溶酶体酶使组织蛋白水解，产生的不饱和脂肪酸引发脂质过氧化方应，破坏细胞膜的结构和功能；释放的炎性细胞因子，激发其他的免疫细胞的功能，导致进一步的组织损伤和坏死，加重SAP的病理损伤，最终导致休克、脓毒血症及多器官功能障碍等严重后果。

Matrix metalloproteinase 9 (MMP9) is one of the representative substances that can degrade basement membrane and extracellular matrix.

基质金属蛋白酶9(matrix metalloproteinase 9，MMP9)是降解细胞基底膜，包括细胞外基质的代表性物质。

DATA SYNTHESIS: Il-17 exerted the biological function after combines with its receptor maybe induced the occurrence and the development of the osteoarthritis by the way of increasing the chondrocyte, expression of inducible nitricoxide synthase and nitrogen monoxide, boosting up the tbe chondrocyte and the expression of MMP-1/3/13, boosting up the activation of the aggrecanase and the collagenase, boosting the decompose of the cartilage proteoglycan and collagen, boosting up the monocyte evocable breakage of the cartilaginous matrix.

资料综合：白细胞介素17通过与其受体结合发挥生物学作用，其可能通过增加关节软骨细胞诱导性一氧化氮合酶表达和一氧化氮产量，增强软骨细胞基质金属蛋白酶（MMP-1／3／13）的表达，增强蛋白聚糖酶和胶原酶活性，促进软骨蛋白多糖及胶原降解，并增强单核细胞对软骨基质的破坏，从而诱导和加速骨关节炎的发生和发展。

By using low-frequency dynamic frequency density wave, the OA kneepad could regulate many aspects of pathological process of knee OA including: inhibition of biological effects of cytokine, MMP-3, HA, oxygen free radicals and NO; enhancing the biological activity of SOD; up-regulating the mRNA expression of Bcl-2 as well as down-regulating the mRNA expression of P53, thereby to inhibit the apoptosis of cartilage cells and delay the cartilage degeneration of the macro-morphology, cartilage cells and cartilage matrix.

OA护膝采用低频温热动态变频疏密波，针对膝OA病理过程中的多个环节进行调节，能有效抑制细胞因子、MMP－3、HA、氧自由基、NO的生物学效应，增强SOD的生物学活性，提高关节软骨细胞Bcl-2mRNA表达，减弱软骨细胞P53mRNA表达，从而抑制软骨细胞凋亡，延缓膝关节软骨宏观形态、软骨细胞及软骨基质的退变。

Research of extracellular matrix is an important subject in tissue engineering, and also a problem of succedaneum of ECM.

细胞外基质研究是组织工程学的重要部分，即是重要基础研究内容，又是研究细胞外基质的替代物课题。

RESULTS: The AF cells cultured in different substrates were morphologically undistinguishable. Toluidine blue staining showed that there was also no difference between AF cells cultured on flexible silicone membranes and in plastic plates. The cells growing in different substrates expressed the same levels of collagen typeⅠ,Ⅱ and aggrecan mRNA and integrin β1. AF cells grew well on silicone membranes.

结果：种植于不同基质的纤维环细胞形态学观察无明显差别；在两种基质上的纤维环细胞甲苯胺蓝染色无差异；Ⅰ，Ⅱ型胶原及聚集蛋白聚糖mRNA及细胞膜整合素β1的表达亦无明显差异；纤维环细胞可以黏附于硅橡胶膜上生长。

Matrix extracelluar phosphoglycoprotein, which is one of the matrix extracelluar non-collage-nous proteins, is expressed in bone, teeth and renal proximal convoluted tubules.

细胞外基质磷酸糖蛋白是一种细胞外基质的非胶原性磷酸化糖蛋白，主要表达于骨组织、牙组织和肾近球小管中，在骨形成矿化以及调节磷吸收方面发挥重要作用。

One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活，ICAM-1表达升高，与被激活的PMN表面表达的LFA-1相结合，&PMN-EC&相互作用加剧，一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍；另一方面粘附的PMN过度吞噬或激活，当白细胞吞噬的颗粒不能被封闭隔离，连同细胞内的酶被释放出来，其中的PMN-elastase能够降解细胞基质中各种成分，水解多种蛋白，加重胰腺的毛细血管内皮细胞和腺泡的损伤；释放的溶酶体酶使组织蛋白水解，产生的不饱和脂肪酸引发脂质过氧化方应，破坏细胞膜的结构和功能；释放的炎性细胞因子，激发其他的免疫细胞的功能，导致进一步的组织损伤和坏死，加重SAP的病理损伤，最终导致休克、脓毒血症及多器官功能障碍等严重后果。

Although someone has narrated cell framework of acellular membrane,no ideal preparation of ABCB or histomoiphometry of bone lacunas have been reported in details.

虽然，一些人对脱细胞的骨细胞外骨架进行了描述，但迄今为止还没有见到较理想的脱细胞骨细胞外基质的制备及骨细胞外基质骨陷窝计量检测的详细报道。

Combined use of trypsin, hypertonic solution and chemical detergent is a better method to prepare acellular vascular matrix, and the vascular matrix be wellpreserved in liquid nitrogen.

液氮保存后1、2、3月扫描电镜观察与新鲜标本无明显差别。结论酶、低渗溶液、化学除垢剂联合法是制备脱细胞血管基质的较好方法，制得的脱细胞血管基质可放入液氮中保存。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。