细胞坏死

AIM: To study the effect of tumor necrosis factor-α on the expression of matrix metalloproteinases in the cultured bovine trabecular cellsand approach to pathogenesis and mechanism of primary open angle glaucoma.

摘要目的：观察肿瘤坏死因子-α对体外培养的牛眼小梁细胞MMP3，MMP9和TIMP-2表达的影响，探讨原发性开角型青光眼的发病机制。

Combined therapy is able to reduce the inflammatory cell adhesions and infiltrations, and alleviate inflammatory immunoreactions and neuron necrosis.

针药结合可降低炎性细胞粘附、浸润，减缓炎症免疫反应，减轻神经元坏死程度。

MAIN OUTCOME MEASURES: The expression of TNF-αand IL1-β in rat macrophages.

主要观察指标：大鼠巨噬细胞肿瘤坏死因子α和白细胞介素1β的表达强度。

Experimental Center of National Level One, Hubei Traditional Chinese Medica l College, Wuhan 430061）Abstract To investigate the protective effects of Jiaweisinisa n on acute liver injury induced by intraperitoneal injection of D-ga lac-tosamise, serum superoxide dismutase, malondialdehyde , glutathioe contents were measured. The pathological changes of liver wer e observed simultaneously. The results showed that JWSNS could decrease serum MD A content, but increase serum SOD and GSH activities in acute liver injury induc ed by D-GalN. It was also found that JWSNS could alleviate the degeneration and necrosis of the hypatocytes.

为研讨加味四逆散防治肝损伤的作用机理，通过动物试验，先用加味四逆散预防给药，再采用D-氨基半乳糖造成大鼠急性肝损伤模型，然后检测大鼠血清超氧化物岐化酶、丙二醛、还原型谷胱甘肽水平，同步观察该方对急性肝损伤大鼠体内脂质过氧化反应及肝脏病理改变的影响，结果表明该方可明显升高大鼠血清SOD、GSH水平，降低MDA水平，肝脏病理学检查亦表明该方使肝细胞变性坏死程度减轻。

Objective To investigate the relationship between the hepatocyte apoptosis,TNF-a and oxygen free radical in alcoholic liver diseasein rats.

目的：探讨大鼠酒精性肝病肝细胞凋亡与肿瘤坏死因子-a及氧自由基的关系。

Fatty and vacuole-like degeneration, necrosis and production of collagen were observed in the model rats.

试验组大鼠肝细胞出现明显脂肪、空泡变性，坏死及胶原增生等病变。

Apoptosis and necrosis are two different forms of cell death in myocardial ischemia/reperfusion injury.

凋亡和坏死是急性缺血再灌注过程中心肌细胞死亡的两种不同形式。

Results Cerebroedema appeared in all animals and they have some behavioral alterations. The meninges tighten, the brain swollen overtly. The adventitia of the brain arteries and the perivascular Virchow－ Robin space dilated irregularly. In some neurons both the nucleus and cytoplasm condensed, chromatin gathered near the nuclear membrane. Some other neurons appeared degeneration or necrosis. There was intracelluar edema of the astrocytes.

结果所有动物均发生脑水肿，表现行为异常，脑膜及脑组织肿胀、充血，小血管壁外膜及Virchow－Robin间隙增宽，内含大量水肿液，毛细血管基底膜肥厚，神经元固缩、轮廓不清晰或肿胀、坏死，胶质细胞增生、肿胀，硬脑膜表面凹凸不平、水肿明显。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。