细胞坏死

Objective To observe the change of macrophages in peritoneal cavity, immune function, and TNF-α in peritoneal fluids after a pneumoperitoneum with insufflating carbon dioxide (CO2) or helium in rat model, investigating the effects of different gases on peritoneal local immunity.

目的 研究二氧化碳(CO2)、氦气在模拟气腹条件下，动物模型腹腔巨噬细胞的数量、免疫功能和腹腔液中肿瘤坏死因子－α含量的变化，探讨不同气体对机体腹腔内局部免疫的影响。

Several growth factors have been confirmed to be related to CNV and these factors include vascular endothelium growth factor , basic fibroblast growth factor , platelet derived growth factor , transforming growth factor-β and tumor necroses factor-α etc.

已经肯定与CNV相关生长因子有：血管内皮生长因子、碱性成纤维细胞生长因子、血小板源性生长因子、转化生长因子-β和肿瘤坏死因子—α等。

HE, Hoechest 33258 fludrescence staining and immunohistochemistry of Bcl-2 protein were used to illustrate the osteocyte apoptosis in femoral neck specimens from 10 cases of normal control and 30 cases of femoral head fractures and traumatic femoral head necroses, which were divided into early, middle and advanced stages.

方法］采用光镜观察、Hoechest33258荧光染色及Bcl-2蛋白免疫组化染色对股骨颈骨折和创伤性股骨头坏死患者共30例和10例正常对照的股骨头标本进行组织学观察、骨细胞凋亡和Bcl-2蛋白检测。

Therefore, the purpose in this study is to observe the change of blood vessel endothelium function and cytokine (tumor necroses factor-α TNF-α, interleukin-6 IL-6) and to investigate the mechanism of Carvedilol improve cardiac function in the patients with CHF.

本实验通过观察CHF患者血管内皮功能和细胞因子：肿瘤坏死因子-α(tumor necrosis factor-α，TNF-α)、白介素-6(interleukin-6，IL-6)的改变，以及使用卡维地洛后CHF患者这两方面的变化与心功能的改善的相关性，并探讨卡维地洛对CHF改善心功能的可能作用机制，为卡维地洛治疗慢性充血性心力衰竭提供临床依据。

METHODS: After Feulgen staining, 40 paraffin samples of astrocytic tumors were observed about DI and 5cER by image analysis, MRI appearances were reviewed, including edema around tumor, clearity of boundary, equality of MRI singal, enhancement of tumor, shift of medline, necroses and cyst, then compared them with pathological grade and survival rate.

40例星形细胞肿瘤石蜡标本经Feulgen染色后，用图像分析仪检测其DNA指数及超5倍体率(5cER)；复习患者MRI表现，包括：瘤周水肿程度、边界是否清楚、信号是否均匀、病灶是否明显强化、病灶是否过中线、有无囊变坏死6项指标，与肿瘤病理分级诊断及生存率相比较。

objective: to investigate the relation of tumor necrosing foctor α and hepatis apoptosis and the effect of liver function in sepsis.

目的：探讨脓毒症大鼠肿瘤坏死因子 a与肝细胞凋亡的关系以及对肝功能的影响。

Objective:To investigate the effects of endotoxin pretreatment on the secreting of TNF-α, and NO in peripheral blood mononuclear cells in rat.

目的：探讨内毒素预处理对单个核细胞分泌肿瘤坏死因子α、诱生型一氧化氮合酶和NO的影响。

Results After 3 months of kidney radiation by 15 Gy of Cs137 γ-rays, the changes with kidney shrank, Bowman's capsules straitened or disappeared, glomerular swelled, some epithelia denaturalized or died were observed. Mitochondria tumefied and the cristae shortened, lessened and disordered. Urine β2-MP rose evidently. It was lowered significantly the renal 25-OH-D-1α-hydroxylase activity and its mRNA expression. The dry and ash weight, BMD of femur and lumbar were significantly reduced, volume and width of bone trabecula were distinctly decreased and the space increased in model group. The Pyd / Cr increased and ALP decreased as well.

结果 15Gy 137Cs-γ射线肾局部照射3个月后肾脏体积缩小，肾小球肿大，Bowman氏囊囊腔狭窄甚至消失，部分肾小管上皮细胞变性、坏死，线粒体肿胀，体积增大，线粒体嵴变短、减少、排列紊乱；尿β2-MP显著增加；肾1α羟化酶活性及1α羟化酶mRNA基因表达量明显下降；肾辐射组股骨干重、灰重、腰椎和股骨BMD明显降低；骨小梁体积和骨小梁宽度减少，骨小梁间距增加，MAR减小；腰椎压缩和股骨三点弯最大载荷明显降低，Pyd / Cr值明显增加，ALP显著降低。

The mitotic count was higher than 5/50HPF in 5 cases in which the diameters of tumor were above or equal to 5 cm. Cystification, hemorrage or necrosis were found in 4 cases and mucification in 1 case. The mitotic count was 2-5/50HPF in 2 cases which were epithelioid cell and tumor diameter were 2-4 cm with mucification in 1 case.

核分裂像大于5/50HPF的5例中肿瘤直径均大于或等于5 cm，其中4例伴有囊性变、出血或坏死，1例伴有黏液样变。2例核分裂像在2~5/50HPF者均为上皮样细胞型，其中1例伴有黏液样变，肿瘤直径均2~4 cm。

Under the adjustment and control of cell growth factors, the cleavage and proliferation of the chondrocytes may be promoted in vitro.

体外研究发现，在白介素-1β和肿瘤坏死因子存在的条件下，IGF-Ⅰ仍能促进软骨细胞的蛋白多糖合成。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。