细胞坏死

Results:(1) The 90Y activity was higher while the contumination of 90Sr was less than 0.0031%;(2) The efficiency of 90Y-labeled antibodies was over 90%,the activity of labeled antibody maintained 82.3%;(3) Tumor size of all 90Y-antibody-treated model was significantly less than that of all 90Y-Cl3-treated model, the average survival time of the mice of the 90Y-antibody-treated group was significantly longer than that of the 90Y-Cl3-treated group;(4) In the tissue sections extensive necrosis was observed in all 90Y-antibody-treated tumor, the living tumor cells were immunohistochemically stainable with PcNA.

结果：(1)EDTA淋洗法制备90Y纯度高，其相对含量可达99.997％；(2)单克隆抗体的90Y标记率达90％以上，抗体蛋白活性保持82.3％；(3)治疗结果表明治疗组肿瘤明显小于对照组，原肿瘤的指数生长规律遭到破坏，治疗组生存期明显长于对照组；(4)组织学切片显示治疗组肿瘤有广泛坏死，PcNA免疫组化显示治疗组肿瘤细胞增殖受到明显抑制。

Objective To perform an initial study on possible molecular regulatory mechanisms of TNF-α to the permeability of strial capillary endothelial cells in guinea pig cochlea.

目的 探讨肿瘤坏死因子α对豚鼠耳蜗血管纹微血管内皮细胞通透性的影响及可能的分子调控机理。

Results After 3 days for operation, HE staining showed multi-focal myocardial necrosis with inflammatory cells infiltration and necrosis with more involvement in subendocardial region.

结果 术后3天，微栓塞组心肌内点状分布的坏死灶形成，多位于心内膜下，周围炎症细胞浸润明显增多，符合微栓塞病理学改变。

The basic pathological changes are fibrinoid necrosis, infiltration and exudation in the subcutaneous, submucous, and subserous tissues near the blood vessels.

本病的基本病理变化是毛细血管及小动脉发生免疫性病变，引起血管壁有纤维素样坏死，皮下、粘膜下及浆膜下组织的血管周围浸润及血浆样渗出，并有炎症细胞浸润。

ASP model was established by injecting with 35 g/L taurocholic acid into the biliopancreatic duct. Both groups were sacrificed at 3, 6 and 12 h with 8 rats at each time point. At scheduled time, bronchoalveolar lavage fluid was drawn and PMNs were then obtained by gradient density gradient centrifugation method. ratio of apoptosis and necrosis of PMN was assayed by flow cytometry and LDH as well as index of lung permeability were measured.

实验组大鼠穿刺胰胆管并注入35 g/L牛磺胆酸钠制作ASP大鼠模型，分别在制模后3， 6， 12 h剖杀，于预定时相取支气管灌洗液，密度梯度离心分离PMN，用流式细胞仪测定PMN凋亡、坏死比例，同时测定乳酸脱氢酶含量、肺通透指数。

ASP model was established by injecting with 35 g/L taurocholic acid into the biliopancreatic duct. Both groups were sacrificed at 3, 6 and 12 h with 8 rats at each time point. At scheduled time, bronchoalveolar lavage fluid was drawn and PMNs were then obtained by gradient density gradient centrifugation method. The ratio of apoptosis and necrosis of PMN was assayed by flow cytometry and LDH as well as index of lung permeability were measured.

实验组大鼠穿刺胰胆管并注入35 g/L牛磺胆酸钠制作ASP大鼠模型，分别在制模后3， 6， 12 h剖杀，于预定时相取支气管灌洗液，密度梯度离心分离PMN，用流式细胞仪测定PMN凋亡、坏死比例，同时测定乳酸脱氢酶含量、肺通透指数。

ASP model was established by injecting with 35 g/L taurocholic acid into the biliopancreatic duct. Both groups were sacrificed at 3, 6 and 12 h with 8 rats at each time point. At scheduled time, bronchoalveolar lavage fluid was drawn and PMNs were then obtained by gradient density gradient centrifugation method. The ratio of apoptosis and necrosis of PMN was assayed by flow cytometry and LDH as well as index of lung permeability were measured.

实验组大鼠穿刺胰胆管并注入35 g/L牛磺胆酸钠制作ASP大鼠模子，分别在制模后3， 6， 12 h剖杀，于预定时相取支气管灌洗液，密度梯度离心疏散PMN，用流式细胞仪测定PMN凋亡、坏死比例，同时测定乳酸脱氢酶含量、肺通透指数。

This trichrome stain demonstrates the collapse of the liver parenchyma with viral hepatitis.

三色染色可见病毒性肝炎肝细胞的坏死。

After administration of L-N〓-nitro-Arginine, a specific antagonist of NOS, it was found that the basal and stimulated NO release of blood vessels (aorta, internal carotid, renal and mensenteric artery) was decreased further. The increase of coronary blood flow stimulated by Ach was also reduced further, while the platelet aggregation degree and erythrocyte aggregation index increased significantly. Pathological examination indicated that aortic endothelium was destroyed, the blood vessels in cerebral, cardiac and renal tissues were hypertrophied further and some were almost occluded. The above fin dings resulted in SHR feeded with L-NNA having high incidence of stroke rate and high degree of renal cirrhosis when compared to control SHR. The infarct and hemorrhagic focuci in cerebral tissues, infarct focuci in cardiac tissues, atrophy and hyalinedegeneration of renal glomeruli and degeneration even necrosis of renal tubuli in renal tissues were al so found. The increase ratio of brain and heart to body weight and decrease ratio of kidney to body wei ght further demonstrated that the cerebral, cardiac and renal injuries were aggravated.

在上述结果的基础上进一步给予SHR NOS特异性拮抗剂左旋亚硝基精氨酸后，血管(胸主、颈内、肾及肠系膜动脉)NO基础释放及激动剂刺激释放进一步减少，Ach刺激冠脉流量的增加和胸主动脉内膜NOS活性也进一步减少，血小板聚集程度及红细胞聚集指数显著上升，病理切片显示胸主动脉内皮细胞破坏明显，脑心肾组织内的血管进一步增厚甚至几乎阻塞，导致饲L-NNA的SHR缺血性及出血性脑卒中发生率显著高于对照SHR，脑体重比显著升高；心肌内出现明显的缺血梗塞疤痕灶，心体重比显著升高；肾小球明显萎缩、玻璃样变性，肾小管也变性甚至坏死，使肾硬化程度显著增加呈颗粒性固缩肾，肾体重比也显著减少。

In nude mice, large and invasive tumors were found after injection of HuH7 cells subcutanesously. While mice injected with SeLT cells demonstrated highly vacuolated cells-filled tissue masses, severe necrosis, 4 inflammation as well as degenerated blood vessels.

利用皮下注射肝癌细胞株到裸鼠之后，实验发现HuH7 形成较大的肿瘤、有大量的血管形成且有转移的现象，而SeLT 虽然能够形成tissue mass 但其中大部分的细胞都有严重坏死及发炎的现象产生，伴随著新血管也呈现有萎缩的现象。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。