细胞坏死

Page=8 The heavy concentration of apple cider vinegar results to peeling off dead skin cells.

浓度高的苹果醋有助于皮肤中坏死、衰老细胞的清除。

Background and purpose : Comedo necrosis is one of the poor prognostic factors in DCIS , and both invasion and metastasis of cancer are the main causes for poor prognosis .

背景与目的粉刺型坏死是导管原位癌预后不良的因素之一，肿瘤细胞侵袭和转移是预后不良的主要原因。

Abstract］ Background and purpose:Comedo necrosis is one of the poor prognostic factors in DCIS, and both invasion and metastasis of cancer are the main causes for poor prognosis.

摘要］背景与目的：粉刺型坏死是导管原位癌预后不良的因素之一，肿瘤细胞侵袭和转移是预后不良的主要原因。

Methods Mimicry and speculation on possible displaced amino acids in proper positions of peptide increased the biological effects of TNFR blocking peptide by compote modeling. The original peptide and its mutant were synthesized. The competitively inhibitory effects on green fluorescence protein-tumor necrosis factor fusion protein with TNFR were compared between original peptide and its mutant (receptor competitively inhibitory binding assays). The inhibitory effects on cytotoxicity were compared between original peptide and its mutant.

通过计算机模建，模拟并推测提高TNFR封闭肽生物学效应需置换的位点和氨基酸；合成原封闭肽和突变肽；受体竞争抑制结合实验比较原肽与突变肽对绿色荧光蛋白－肿瘤坏死因子融合蛋白结合TNFR的竞争抑制效应；细胞毒作用抑制实验比较原肽与突变肽对TNFR的封闭效应。

METHODS: Cytotoxicity of the combination of TNF-α and IFN-γ on HCC in vitro was measured by using a crystal violet staining method.

采用结晶紫染色法测定肿瘤坏死因子-α、干扰素-γ和两者联合用药体外杀灭肝癌细胞的能力。

In some cases there is severe angitis and fibrinoid necrosis of the vascular wall with perivascular cuffing by lymphocytes and plasma cells. Trophozoites and cysts were found within the perivascular space.

有的病例可见显著的血管炎，病变血管壁可见纤维素样坏死，血管周围可见淋巴细胞和浆细胞呈套袖样浸润及棘阿米巴滋养体和包囊。

On the basis of MEBT, a new technique hypothesis of injecting MEBO under the eschar was proposed to have 6 biochemical reactions available, such as hydrolysis, enzymolysis, saponification, rancidify, lipofication, esterification of MEBO with necrotic tissue of the eschar, then to realize liquefaction and quick defluxion of necrotic tissues, This finally to play a role of regenerative action of MEBO in situ to turn potential regenerative cells into skin stem cells that would further proliferate and differentiate to form skin tissues, reaching the goal of physiologically repairing wounds.

最后提出了在烧伤湿性医疗技术正规治疗的基础上，同时进行痂下注射MEBO的新技术设想，其目的是使痂下组织尽早接受MEBO的治疗，痂下发挥MEBO的水解、酶解、皂化、酸败、脂化、酯化六大生物化学反应，促使坏死组织痂下痂外一起液化，尽快脱落；而且在痂下发挥MEBO原位再生作用，使潜能细胞转变成皮肤干细胞，干细胞进一步增殖分化形成皮肤组织，达到创面生理性修复之目的。

Results Punctiform erosion, hemorrhage were observed by nake eyes in each groups. Epithelium cellular necrosis, defluxion, neutrophil being dominant in propria lamina and intact glandular were observed with microscopy. The erosion became severe with the successive stimulate of ethanol. There is no difference between distillate spirit and sodium chloride rats in Guth in 7th day, but Guth in distillate spirit rats was higher than that in sodium chloride rats in 30th day. PGE2, TGF-α contents in gastric mucosa of treated group increased significangly compared with control group. PGE2 showed no difference between each group in 7th and 30th day; TGF-α in gastric mucosa of distillate spirit and sodium chloride rats decreased after 1 month.

结果 茅台组、乙醇组、生理盐水组胃黏膜均肉眼可见程度不同的点状糜烂、出血；光镜下黏膜部分上皮坏死脱落，固有层以中性粒细胞为主炎性细胞浸润，腺体结构基本完整，病变随时间延长有所加重，Guth积分1周茅台组与生理盐水组差异无统计学意义，1月两者相比差异有统计学意义；茅台组、乙醇组胃黏膜组织内PGE2水平与生理盐水组相比明显增高，同时TGF-α表达增强；但PGE2水平各组间1周与1月相比差异无统计学意义；TGF-α表达强度在茅台组、生理盐水组1月后逐渐降低，差异有统计学意义。

RESULTS: After ischemia-reperfusion injury, the rats had hydrouria, urine osmotic pressure depress, symptoms of carnine and urea nitrogen increasing. HE staining demonstrated that renal tubular epithelial cells were swelling, necrosis, and desquamate. Aquaporin-1 expression and its mRNA level was decreased; in particular, the expression and level were the lowest at day 1 after ischemia-reperfusion injury and recovered to normal value at day 5 after ischemia-reperfusion injury.

结果：大鼠肾脏缺血再灌注损伤后出现尿量增多、尿渗透压降低，血肌苷、尿素氮升高症状；苏木精-伊红染色示肾小管上皮细胞肿胀、坏死、脱落；水通道蛋白表达量及其mRNA含量均较对照组减少，这些变化于缺血再灌注损伤 1 d时最低，至缺血再灌注损伤 5 d时恢复正常。

Purpose To investigate the effect of LPS and dialyzer membrane on tumor necrosis factor α and soluble tumor necrosis factor receptor p55(TNFsRp55)production in PBMC from uremic patients and healthy controls.

目的 研究不同透析膜和内毒素对正常人和尿毒症患者外周血单个核细胞肿瘤坏死因子α及其可溶性受体p5 5 (TNFsRp5 5 )产生的影响。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。